Elevated incidence of hypospadias in two sicilian towns where exposure to industrial and agricultural pollutants is high

Reproductive Toxicology

Volumn 17, Issue 5, 2003, Pages 539-545

  Bianca, Sebastiano ^a   Li Volti, Giovanni ^a   Caruso Nicoletti, Manuela ^a   Ettore, Giuseppe ^a   Barone, Patrizia ^a   Lupo, Lorenzo ^a   Li Volti, Salvatore ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Agricultural pollutants; Chemical pollutants; Confounding factors; Endocrine disruptors; Genital anomalies; Hypospadias; Industrial pollutants; Toxic environmental agents

Indexed keywords

AGRICULTURAL CHEMICAL; INDUSTRIAL CHEMICAL;

ADULT; AGED; ARTICLE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FEMALE; GENETICS; HUMAN; HYPOSPADIAS; INCIDENCE; ITALY; MAJOR CLINICAL STUDY; MALE; MALE GENITAL SYSTEM; OCCUPATIONAL EXPOSURE; RISK FACTOR; SEX DIFFERENTIATION; VIRILIZATION;

EID: 0242287181     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(03)00099-6     Document Type: Article

References (46)

1. O'Rahilly R, Muller F. Human embryology and teratology. New York: Wiley; 1992.
2. EUROCAT Working Group. EUROCAT Report. 15 years of surveillance of congenital anomalies in Europe 1980-1994. Brussels: Scientific Institute of Public Health-Louis Pasteur; 1997.
3. Sicilian Registry of Congenital Malformations: 1991-1998 report. Sic J Mat Child Care 1999;11:6-16.
4. Kallèn B, Wimberg J. An epidemiological study of hypospadias in Sweden. Acta Paediatr Scand 1982;293(Suppl):1-21.
5. Campbell H, Newcombe RG, Weatherall JA. Epidemiology of simple hypospadias. Br Med J 1973;iii:52-3.
6. Bjerkedal T, Bakketeig LS. Surveillance of congenital malformations and other conditions of the newborn. Int J Epidemiol 1975;4:31-6.
7. Czeizel A, Toth J, Erodi E. Aetiological studies of hypospadias in Hungary. Hum Hered 1979;29:166-71.
8. Paulozzi LJ, Erickson JD, Jackson RJ. Hypospadias trends in two US surveillance systems. Pediatrics 1997;100:831-4.
9. International Clearinghouse for Birth Defects Monitoring Systems, Annual Reports 1980-1993. Rome: International Centre for Birth Defects; 1982-1995.
10. Paulozzi LJ. International trends in rates of hypospadias and chryptorchidism. Environ Health Perspect 1999;107:297-302.
11. Virtanen HE, Kaleva M, Haavisto AM, Schmidt IM, Chellakooty M, Main KM, et al. The birth rate of hypospadias in the Turku area in Finland. APMIS 2001;103(Suppl):S43-7.
12. Haqq CM, King CY, Ukiyama E, Falsafi S, Haqq TN, Donohoe PK, et al. Molecular basis of mammalian sexual determination: activation of Mulleran inhibiting substance gene expression by SRY. Science 1994;266:1494-500.
13. Toppari J, Larsen JC, Christiansen P, Giwereman A, Randjean P, Guillette Jr LJ, et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 1997;105:162-3.
14. Keller EF. A feeling for the organism. New York: Freeman WH and Company; 1983. p. 205-6.
15. Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 1993;101:378-84.
16. Majdic G, Sharpe RM, O'Shaughnessy PJ, Saunders PTK. Expression of cytochrome P450 17α-hydroxylase/C17-20 lyase (P450c17) in the fetal rat testis is reduced by maternal exposure to exogenous oestrogens. Endocrinology 1996;137:1063-70.
17. Iguchi T. Cellular effects of early exposure to sex hormones and antihormones. Int Rev Cytol 1992;139:1-57.
18. Foster PM, Mylchreest E, Gaido KW, Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update 2001;7:231-5.
19. Baker VA. Endocrine disrupters-testing strategies to assess human hazard. Toxicol In Vitro 2001;15:413-9.
20. Klassen C. Cassarett and Doull's toxicology: the basic science of poisons, 5th ed. New York: McGraw-Hill; 1996.
21. Pastore LM, Hertz-Picciotto I, Beaumont JJ. Risk of stillbirth from occupational and residential exposures. Occup Environ Med 1997;54:511-8.
22. Stoll C, Alembik Y, Roth MP, Dott B. Genetic and environmental factors in hypospadias. J Med Genet 1990;27:559-63.
23. Mylchreest E, Sar M, Cattley RC, Foster PM. Disruption of an androgen-regulated male reproductive development by di(n-butyl)phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 1999;15:81-95.
24. Barcat J. Current concepts of treatment. In: Horton CE, editor. Plastic and reconstructive surgery of the genitalia area, 8th ed. Boston: Little Brown; 1973. p. 249.
25. Shaw GM, Wasserman CR, O'Malley CD, Nelson V, Jackson RJ. Maternal pesticide exposure from multiple sources and selected congenital anomalies. Epidemiology 1999;10:60-6.
26. Leite IC, Paumgartten FJ, Koifman S. Chemical exposure during pregnancy and oral cleft in newborns. Cad Saude Publica 2002;18:17-31.
27. Loffredo CA, Silberged EK, Ferencz C, Zhang J. Association of transposition of the great arteries in infants with maternal exposure to herbicides and rodenticides. Am J Epidemiol 2001;15:529-36.
28. Muccinelli M. Prontuario del fitofarmaci, VIII ed. Bologna: Edagricole; 1997.
29. Tran DQ, Kelvin YK, McLachlan JA, Arnold SF. The inhibition of estrogen receptor-mediated responses by chloro-s-triazine-derived compounds is dependent on estradiol concentration in yeast. Biochem Biophys Res Commun 1996;227:140-6.
30. Gray LE, Ostby JS, Kelce WR. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol 1994;129:46-52.
31. Alem TD, Griffin JE. Endocrine studies in patients with advanced hypospadias. J Urol 1984;131:310-4.
32. Glatzl J. Endocrinological problems in malformation of the male genitalia. Prog Pediatr Surg 1984;17:1-10.
33. Hiort O, Klauber G, Cendron M, Sinnecker GH, Keim L, Scwinger E, et al. Molecular characterization of the androgen receptor gene in boys with hypospadias. Eur J Pediatr 1994;153:317-21.
34. Edelstein RA, Carr MC, Caesar R, Young M, Atala A, Freeman MR. Detection of human androgen receptor mRNA expression abnormalities by competitive PCR. DNA Cell Biol 1994;13:265-73.
35. Sutherland RW, Wiener JS, Hicks JP, Marcelli M, Gonzales Jr ET, Roth DR, et al. Androgen receptor gene mutations are rarely associated with isolated penile hypospadias. J Urol 1996;156:828-31.
36. Codner E, Okuma C, Johnson MC, Iniguez G, Boric A, Avila A, et al. Molecular analysis of the 3β-hydroxysteroid dehydrogenase type II gene (HSD3B2) in patients with idiopathic hypospadias. Pediatric Endocrinology Montreal 2001, July 6-10, 2001. Ped Res 2001; 49 (Abstract Issue): P3-323, 55A.
37. Baskin LS. Hypospadias and uretHral development. J Urol 2000;163:951-6.
38. Weidner IS, Moller H, Jensen TK, Skakkebaek NE. Cryptorchidism and hypospadias in sons of gardeners and farmers. Enviorn Health Perspect 1998;106:793-6.
39. Dolk H. Rise in prevalence of hypospadias. Lancet 1998;351:770.
40. Weidner IS, Moller H, Jensen TK, Skakkebaek NE. Risk factors for cryptorchidism and hypospadias. J Urol 1999;161:1606-9.
41. Akre O, Lipworth L, Cnattingius S, Sparen P, Ekbom A. Risk factor patterns for cryptorchidism and hypospadias. Epidemiology 1999;10:352-4.
42. Gatti JM, Kirsch AJ, Troyer WA, Perez-Brayfield MR, Smith EA, Scherz HC. Increased incidence of hypospadias in small-for-gestational age infants in a neonatal intensive-care unit. BJU Int 2001;87:548-50.
43. Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 2000;151:862-77.
44. Garcia AM, Fletcher T, Benavides FG, Orts E. Parental agricultural work and selected congenital malformations. Am J Epidemiol 1999;149:64-74.
45. Bell EM, Picciotto-Hertz I, Beaumont JJ. A case-control study of pesticides and fetal death due to congenital anomalies. Epidemiology 2001;12:148-56.
46. Lutwak-Mann C, Schmid K, Keberle H. Thalidomide in rabbit semen. Nature 1967;214:1018-20.