A Caveat Emptor for myocardial regeneration: Mechanical without electrical recovery will not suffice

Journal of Molecular and Cellular Cardiology

Volumn 42, Issue 2, 2007, Pages 285-288

  Cohen, Ira S ^a,b   Rosen, Amy B ^b,c   Gaudette, Glenn R ^d  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c Stony Brook University   (United States)

^d Worcester Polytechnic Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; GAP JUNCTION PROTEIN;

ACTION POTENTIAL; CELL DIFFERENTIATION; CELL LOSS; CELL PROLIFERATION; CELL REGENERATION; EDITORIAL; EMBRYONIC STEM CELL; ENDOCARDIUM; ENDOTHELIUM CELL; EPICARDIUM; GAP JUNCTION; HEART CONTRACTION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; HEART PACING; HUMAN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ARRHYTHMIA; CELL SURVIVAL; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; GRAFT SURVIVAL; HEART CONDUCTION SYSTEM; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOBLASTS, SKELETAL; MYOCARDIAL INFARCTION; RATS; RECOVERY OF FUNCTION; REGENERATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 33846504487     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2006.11.001     Document Type: Editorial

References (27)

1. Kolossov E., Lu Z., Drobinskaya I., et al. Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes. FASEB J. 19 6 (2005) 577-579
2. He J.Q., Ma Y., Lee Y., et al. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ. Res. 93 1 (2003) 32-39
3. Maltsev V.A., Rohwedel J., Hescheler J., et al. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech. Dev. 44 1 (1993) 41-50
4. Laugwitz K.L., Moretti A., Lam J., et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433 7026 (2005) 647-653
5. Fukuda K. Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes. Bone Marrow Transplant. 32 Suppl. 1 (2003) S25-S27
6. Shmelkov S.V., Meeus S., Moussazadeh N., et al. Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue. Circulation 111 9 (2005) 1175-1183
7. Mills W.R., Mal N., Kiedrowski M.J., Unger R., Forudi F., Popovic Z.B., et al. Stem cell therapy enhances electrical viability in myocardial infarection. J. Mol. Cell Cardiol. 42 2 (2007) 304-314 [this issue]
8. Abraham M.R., Henrikson C.A., Tung L., et al. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ. Res. 97 2 (2005) 159-167
9. Hagege A.A., Marolleau J.P., Vilquin J.T., et al. Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients. Circulation 114 1 Suppl. (2006) I108-I113
10. Amado L.C., Saliaris A.P., Schuleri K.H., et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc. Natl. Acad. Sci. U. S. A. 102 32 (2005) 11474-11479
11. Yoon Y.S., Wecker A., Heyd L., et al. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J. Clin. Invest. 115 2 (2005) 326-338
12. Chen S.L., Fang W.W., Qian J., et al. Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction. Chin. Med. J. Engl. 117 10 (2004) 1443-1448
13. Valiunas V., Doronin S., Valiuniene L., et al. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J. Physiol. 555 Pt 3 (2004) 617-626
14. Tang Y.L., Zhao Q., Qin X., et al. Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann. Thorac. Surg. 80 1 (2005) 229-236 [discussion 236-7]
15. Tolmachov O., Ma Y.L., Themis M., et al. Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC Cardiovasc. Disord. 6 (2006) 25
16. Akar F.G., Laurita K.R., and Rosenbaum D.S. Cellular basis for dispersion of repolarization underlying reentrant arrhythmias. J. Electrocardiol. 33 Suppl. (2000) 23-31
17. Antzelevitch C., Yan G.-X., Shimizu W., and Burashnikov A. Electrical heterogeneity, the ECG, and cardiac arrhythmias. In: Zipes D.P., and Jalife J. (Eds). Cardiac Electrophysiology: From Cell to Bedside (2000), W.B. Saunders Co., Philadelphia 222-238
18. Kehat I., Khimovich L., Caspi O., et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat. Biotechnol. 22 10 (2004) 1282-1289
19. Vozzi C., Dupont E., Coppen S.R., et al. Chamber-related differences in connexin expression in the human heart. J. Mol. Cell. Cardiol. 31 5 (1999) 991-1003
20. Li G.R., Feng J., Yue L., et al. Evidence for two components of delayed rectifier K+ current in human ventricular myocytes. Circ. Res. 78 4 (1996) 689-696
21. Shi W., Wymore R., Yu H., et al. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ. Res. 85 1 (1999) e1-e6
22. Yu H., Gao J., Wang H., et al. Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ. Res. 86 10 (2000) 1062-1068
23. Gao J., Kim J., Sun X., Cohen I.S., and Mathias R.T. Gradients in Na/K pump current and Angiotensin II across the canine ventricular wall. 51st Annual Meeting of the Biophysical Society, Baltimore, MD (2006)
24. McGuire M.A., de Bakker J.M., Vermeulen J.T., et al. Atrioventricular junctional tissue. Discrepancy between histological and electrophysiological characteristics. Circulation 94 3 (1996) 571-577
25. Rosen M.R., and Cohen I.S. Molecular/genetic determinants of repolarization and their modification by environmental stress. J. Intern. Med. 259 1 (2006) 7-23
26. Anyukhovsky E.P., Sosunov E.A., Chandra P., et al. Age-associated changes in electrophysiologic remodeling: a potential contributor to initiation of atrial fibrillation. Cardiovasc. Res. 66 2 (2005) 353-363
27. Leobon B., Garcin I., Menasche P., et al. Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc. Natl. Acad. Sci. U. S. A. 100 13 (2003) 7808-7811