Recombinant LH supplementation to recombinant FSH during induced ovarian stimulation in the GnRH-antagonist protocol: A meta-analysis

Reproductive BioMedicine Online

Volumn 14, Issue 1, 2007, Pages 14-25

  Baruffi, Ricardo L R ^a   Mauri, A L ^a,b   Petersen, C G ^a,b   Felipe, V ^a   Martins, A M C ^c   Cornicelli, J ^a   Cavagna, M ^a   Oliveira, J B A ^a   Franco Jr , J G ^a,c  

^a Centre for Human Reproduction Prof Franco Junior   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

GnRH antagonist; Ovarian stimulation; Recombinant FSH; Recombinant LH

Indexed keywords

CETRORELIX; CHORIONIC GONADOTROPIN; ESTRADIOL; GONADORELIN ANTAGONIST; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE;

ARTICLE; CELL COUNT; CLINICAL PROTOCOL; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA BASE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG WITHDRAWAL; EFFECT SIZE; ESTRADIOL BLOOD LEVEL; EVIDENCE BASED MEDICINE; FERTILIZATION IN VITRO; HORMONAL REGULATION; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LOW DRUG DOSE; META ANALYSIS; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; OOCYTE MATURATION; OVULATION INDUCTION; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SINGLE DRUG DOSE; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW;

EID: 33846503177     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)60758-4     Document Type: Article

References (45)

1. Acevedo B, Sanchez M, Gomez JL et al. 2004 Luteinizing hormone supplementation increases pregnancy rates in gonadotropin-releasing hormone antagonist donor cycles. Fertility and Sterility 82, 343-347.
2. Albano C, Smitz J, Camus M et al. 1997 Comparison of different doses of gonadotrophin-releasing hormone antagonist cetrorelix during controlled ovarian hyperstimulation. Fertility and Sterility 67, 917-922.
3. Alviggi C, Clarizia R, Mollo A et al. 2006 Who needs LH in ovarian stimulation? Reproductive BioMedicine Online 12, 599-607.
4. Balasch J, Fábregues F 2006 LH in the follicular phase: neither too high nor too low Reproductive BioMedicine Online 12, 406-415.
5. Balasch J, Creus M, Fábregues F et al. 2001 The effect of exogenous luteinizing hormone (LH) on oocyte viability: evidence from a comparative study using recombinant human follicle-stimulating hormone (FSH) alone or in combination with recombinant LH for ovarian stimulation in pituitary-suppressed women undergoing assisted reproduction. Journal of Assisted Reproduction and Genetics 18, 250-256.
6. Borenstein M 2005 From Narrative Reviews to Systematic Reviews and Meta-Analysis. Meta-Analysis course, www.statistics.com, p. 14.
7. Borini A, Dal Prato L 2005 Tailoring FSH and LH administration to individual patients Reproductive BioMedicine Online 11, 283-293.
8. Cédrin-Durnerin I, Grange-Dujardin D, Laffy A et al. 2004 Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study. Human Reproduction 19, 1979-1984.
9. Chalmers TC, Levin H, Sacks HS et al. 1987 Meta-analysis of clinical trials as a scientific discipline. I. Control of bias and comparison with large co-operative trials. Stastistics in Medicine 6, 315-325.
10. Cook DJ, Mulrow CD, Haynes RB 1997 Systematic reviews: synthesis of best evidence for clinical decisions. Annals of Internal Medicine 126, 376-380.
11. Couzinet B, Lestrat N, Brailly S et al. 1988 Stimulation of ovarian follicular maturation with pure follicle-stimulation hormone in women with gonadotropin deficiency. Journal of Clinical Endocrinology and Metabolism 66, 522-526.
12. Daya S 2002 Updated meta-analysis of recombinant follicle-stimulating hormone (FSH) versus urinary FSH for ovarian stimulation in assisted reproduction. Fertility and Sterility 77, 711-714.
13. Daya S, Gunby J 1999 Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction. Human Reproduction 14, 2207-2215.
14. Delaney A, Bagshaw SM, Ferland A et al. 2005 A systematic evaluation of the quality of meta-analyses in the critical care literature. Critical Care 9, 575-582.
15. De Placido G, Mollo A, Clarizia R et al. 2006 Gonadotropin-releasing hormone (GnRH) antagonist plus recombinant luteinizing hormone vs. a standard GnRH agonist short protocol in patients at risk for poor ovarian response. Fertility and Sterility 85, 247-250.
16. De Placido G, Alviggi C, Perino A et al. 2005 Italian Collaborative Group on Recombinant Human Luteinizing Hormone. Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotrophic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial. Human Reproduction 20, 390-396.
17. De Placido G, Alviggi C, Mollo A et al. 2004 Effects of recombinant LH (rLH) supplementation during controlled ovarian hyperstimulation (COH) in normogonadotrophic women with an inadequate response to recombinant FSH (rFSH) after pituitary downregulation. Clinical Endocrinology 60, 637-643.
18. Ferraretti AP, Gianaroli L, Magli MC et al. 2004 Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques. Fertility and Sterility 82, 1521-1526.
19. Filicori M, Cognigni GE, Taraborrelli S et al. 2001 Luteinizing hormone activity in menotropins optimizes folliculogenesis and treatment in controlled ovarian stimulation. Journal of Clinical Endocrinology and Metabolism 87, 1156-1161.
20. Ganirelix Dose Finding Study Group 1998 A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotropin-releasing hormone antagonist cetrorelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle-stimulating hormone (Puregon). Human Reproduction 13, 3023-3031.
21. Garcia-Velasco JA, Isaza V, Vidal C et al. 2001 Human ovarian steroid secretion in vivo: effects of GnRH agonist versus antagonist (cetrorelix). Human Reproduction 16, 2533-2539.
22. Gomez-Palomares JL, Acevedo-Martin B, Andres L et al. 2005 LH improves early follicular recruitment in women over 38 years old. Reproductive BioMedicine Online 11, 409-414.
23. Griesinger G, Diedrich K 2006 The role of LH in ovarian stimulation: considerations. Reproductive BioMedicine Online 12, 404-406.
24. Griesinger G, Schultze-Mosgau A, Dafopoulos K et al. 2005 Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol. Human Reproduction 20, 1200-1206.
25. Heijnen EMEW, Eijkemans MJC, Hughes EG et al. 2006 A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. Human Reproduction Update 12, 13-21.
26. Huirne JA, van Loenen AC, Schats R et al. 2005 Dose-finding study of daily GnRH antagonist for the prevention of premature LH surges in IVF/ ICSI patients: optimal changes in LH and progesterone for clinical pregnancy. Human Reproduction 20, 359-367.
27. Humaidan P, Bungum M, Andersen YC 2004 Effects of recombinant LH supplementation in women undergoing assisted reproduction with GnRH agonist down-regulation and stimulation with recombinant FSH: an opening study. Reproductive BioMedicine Online 8, 635-643.
28. Kol S, Muchtar M 2005 Recombinant gonadotrophin-based, ovarian hyperstimulation syndrome-free stimulation of the high responder: suggested protocol for further research Reproductive BioMedicine Online 10, 575-577.
29. Kolibianakis EM, Zikopoulos K, Schiettecatte J et al. 2004 Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF. Human Reproduction 19, 2490-2496.
30. Lahoud R, Al-Jefout M, Tyler J et al. 2006 A relative reduction in mid-follicular LH concentrations during GnRH agonist IVF/ICSI cycles leads to lower live birth rates Human Reproduction, Advance Access published on June 19, doi:10.1093/humrep/del219.
31. Leandro G 2005 Meta-Analysis in Medical Research: the Handbook for the Understanding and Practice of Meta-Analysis. BMJ Books, Blackwell Publishing, Oxford, UK, p. 2.
32. Levi-Setti PE, Cavagna M, Bulletti C 2006 Recombinant gonadotrophins associated with GnRH antagonist (cetrorelix) in ovarian stimulation for ICSI: comparison of r-FSH alone and in combination with r-LH. European Journal of Obstetrics and Gynecology and Reproductive Biology 126, 212-216.
33. Lindheim SR, Morales AJ 2003 GnRH antagonists followed by a decline in serum oestradiol results in adverse outcomes in donor oocyte cycles. Human Reproduction 18, 2048-2051.
34. Lisi F, Rinaldi L, Fishel S et al. 2002 Use of recombinant LH in a group of unselected IVF patients. Reproductive BioMedicine Online 5, 104-108.
35. Lisi F, Rinaldi L, Fishel S et al. 2001 Use of recombinant FSH and recombinant LH in multiple follicular stimulation for IVF: a preliminary study. Reproductive BioMedicine Online 3, 190-194.
36. Marrs R, Meldrum D, Mauasher S et al. 2004 Randomized trial to compare the effect of recombinant human FSH (folitropin alfa) with or without recombinant human LH in women undergoing assisted reproduction treatment. Reproductive BioMedicine Online 8, 175-182.
37. Matikainen T, Ding YQ, Vergara M et al. 1992 Differing responses of plasma bioactive and immunoreactive follicle-stimulating hormone and luteinizing hormone to gonadotrophin-releasing hormone antagonist and agonist treatments in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 75, 820-825.
38. Mulrow CD, Oxman AD (eds) 1996 Cochrane Collaboration Handbook. Cochrane Collaboration, Oxford.
39. Sauer MV, Thornton MH, Schoolcraft W, Frishman GN 2004 Comparative efficacy and safety of cetrorelix with or without mid-cycle recombinant LH and leuprolide acetate for inhibition of premature LH surges in assisted reproduction. Reproductive BioMedicine Online 9, 487-493.
40. Shojania KG, Bero LA 2001 Taking advantage of the explosion of systematic reviews: an efficient MEDLINE search strategy. Effective Clinical Practice 4, 157-162.
41. Sills ES, Levy DP, Moomjy M et al. 1999 A prospective, randomized comparison of ovulation induction using highly purified follicle-stimulating hormone alone and with recombinant human luteinizing hormone in in-vitro fertilization. Human Reproduction 14, 2230-2235.
42. Tarlatzis B, Tavmergen E, Szamatowicz M et al. 2006 The use of recombinant human LH (lutropin alfa) in the late stimulation phase of assisted reproduction cycles: a double-blind, randomized, prospective study. Human Reproduction 21, 90-94.
43. Tesarik J, Hazout A, Mendoza C 2003 Luteinizing hormone affects uterine receptivity independently of ovarian function. Reproductive BioMedicine Online 7, 59-64.
44. Westergaard L, Laursen S, Andersen CY 2000 Increased risk of early pregnancy loss by profound suppression luteinizing hormone during ovarian stimulation in normogonadotropic women undergoing assisted reproduction. Human Reproduction 15, 1003-1008.
45. Yusuf S, Collins R, Peto R 1984 Why do we need some large, simple randomized trials? Statistics in Medicine 3, 409-420.