Evaluation of manometric temperature measurement (MTM), a process analytical technology tool in freeze drying, part III: Heat and mass transfer measurement

AAPS PharmSciTech

Volumn 7, Issue 4, 2006, Pages

  Tang, Xiaolin Charlie ^a,c   Nail, Steven L ^b,d   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b PURDUE UNIVERSITY   (United States)

^c CENTOCOR INC   (United States)

^d Baxter Pharmaceutical Solutions LLC   (United States)

Author keywords

Freeze drying lyophilization; Manometric temperature measurement; Process analytical technology for freeze drying; Vial heat transfer coefficient

Indexed keywords

ACCURACY; ANALYTICAL ERROR; ARTICLE; CALCULATION; CONTROLLED STUDY; FLOW RATE; FREEZE DRYING; GRAVIMETRY; HEAT TRANSFER; MANOMETRY; TECHNOLOGY; TEMPERATURE MEASUREMENT; CHEMICAL MODEL; CHEMISTRY; COMPUTER PROGRAM; COMPUTER SIMULATION; ENERGY TRANSFER; EVALUATION; HEAT; MATERIALS TESTING; METHODOLOGY; PHARMACEUTICS; PRESSURE; TEMPERATURE; THERMOGRAPHY;

DRUG; WATER;

COMPUTER SIMULATION; ENERGY TRANSFER; FREEZE DRYING; HEAT; MANOMETRY; MATERIALS TESTING; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PRESSURE; SOFTWARE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THERMOGRAPHY; WATER;

EID: 33846496164     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070497     Document Type: Article

References (12)

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11. Tang XC, Pikal MJ. Evaluation of manometric temperature measurement (MTM) in freeze drying, part II: measurement of dry layer resistance. AAPS PharmSciTech 2006;7:E93.
12. Tang XC, Pikal MJ. Evaluation of manometric temperature measurement (MTM) in freeze drying, part I: product temperature measurement. AAPS PharmSciTech. 2006;7:E14.