Polymorphisms of the methylenetetrahydrofolate reductase gene and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation

Annals of Hematology

Volumn 86, Issue 1, 2007, Pages 41-48

  Kim, Inho ^a,c   Lee, Kyung Hun ^a   Kim, Jin Hee ^a   Ra, Eun Kyung ^a   Yoon, Sung Soo ^a   Hong, Yun Chul ^a   Park, Sung Sup ^a   Kim, Chul Soo ^b   Park, Seonyang ^a,c   Kim, Byoung Kook ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Inha University School of Medicine   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Methotrexate; Methylenetetrahydrofolate reductase; Polymorphism; Stem cell transplantation

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; HLA ANTIGEN; METHOTREXATE; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HLA MATCHING; HUMAN; LIVER TOXICITY; LIVER VENOOCCLUSIVE DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOMES RESEARCH; PHARMACOGENETICS; PRIORITY JOURNAL; SHORT COURSE THERAPY; SIBLING; SURVIVAL RATE; THROMBOCYTE COUNT;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SIBLINGS; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 33846463385     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-006-0184-3     Document Type: Article

References (26)

1. Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Doney K, Farewell V et al (1986) Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med 314:729-735
2. Tishler M, Caspi D, Fishel B, Yaron M (1988) The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients. Arthritis Rheum 31:906-908
3. Joyce DA, Will RK, Hoffman DM, Laing B, Blackbourn SJ (1991) Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid. Ann Rheum Dis 50:913-914
4. Baggott JE, Vaughn WH, Hudson BB (1986) Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 59-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Biochem J 236:193-200
5. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113
6. Bagley PJ, Selhub J (1998) A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95:13217-13220
7. Shaw GM, Rozen R, Finnell RH, Wasserman CR, Lammer EJ (1998) Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida. Am J Epidemiol 148:30-37
8. Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, Rozen R, Oakley GP Jr, Adams MJ Jr (1996) 5,10-Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet 63:610-614
9. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 6:12810-12815
10. van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects? Am J Hum Genet 62:1044-1051
11. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18:295-304
12. Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bone-marrow transplantation. N Engl J Med 292:895-902
13. McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993) Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: A cohort study of 355 patients. Ann Intern Med 118:255-267
14. Reeves GK, Cox DR, Darby SC (1998) Some aspects of measurement error in explanatory variables for continuous and binary regression models. Stat Med 17:2157-2177
15. Urano W, Taniguchi A, Yamanaka H, Tanaka E, Nakajima H, Matsuda Y, Akama H, Kitamura Y, Kamatani N (2002) Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses. Pharmacogenetics 12:183-190
16. Finkelstein JD (1990) Methionine metabolism in mammals. J Nutr Biochem 1:228-237
17. van Ede AE, Laan RF, Blom HJ, Huizinga TW, Haagsma CJ, Giesendorf BA, de Boo TM, van de Putte LB (2001) The C677T mutation in the methylenetetrahydrofolate reductase gene: A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. Arthritis Rheum 44:2525-2530
18. Garcia-Tevijano ER, Berasain C, Rodriguez JA, Corrales FJ, Arias R, Martin-Duce A, Caballeria J, Mato JM, Avila MA (2001) Hyperhomocysteinemia in liver cirrhosis: Mechanisms and role in vascular and hepatic fibrosis. Hypertension 38:1217-1221
19. Robien K, Ulrich CM, Bigler J, Yasui Y, Gooley T, Bruemmer B, Potter JD, Radich JP (2004) Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia. Clin Cancer Res 10:7592-7598
20. Winkelmayer WC, Kramar R, Sunder-Plassmann G, Fodinger M (2005) Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients. Kidney Int 68:2857-2862
21. Kalayoglu-Besisik S, Caliskan Y, Sargin D, Gurses N, Ozbek U (2003) Methylenetetrahydrofolate reductase C677T polymorphism and toxicity in allogeneic hematopoietic cell transplantation. Transplantation 76:1775-1777
22. Ulrich CM, Yasui Y, Storb R, Schubert MM, Wagner JL, Bigler J, Ariail KS, Keener CL, Li S, Liu H, Farin FM, Potter JD (2001) Pharmacogenetics of methotrexate: Toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood 98:231-234
23. Murphy N, Diviney M, Szer J, Bardy P, Grigg A, Hoyt R, King B, Macgregor L, Holdsworth R, McCluskey J, Tait BD (2006) Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate. Bone Marrow Transplant 37:773-779
24. Blount BC, Ames BN (1995) DNA damage in folate deficiency. Baillieres Clin Haematol 8:461-478
25. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, Selhub J (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 99:5606-5611
26. Szczeklik A, Sanak M, Jankowski M, Dropinski J, Czachor R, Musial J, Axenti I, Twardowska M, Brzostek T, Tendera M (2001) Mutation A1298C of Methylenetetrahydrofolate reductase: Risk for early coronary disease not associated with hyperhomocysteinemia. Am J Med Genet 101:36-39