-
3
-
-
0036118114
-
Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice
-
G Battaglia CL Busceti L Cuomo FS Giorgi F Orzi A De Blasi F Nicoletti S Ruggieri F Fornai 2002 Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice Neuropharmacology 42 367 373
-
(2002)
Neuropharmacology
, vol.42
, pp. 367-373
-
-
Battaglia, G.1
Busceti, C.L.2
Cuomo, L.3
Giorgi, F.S.4
Orzi, F.5
De Blasi, A.6
Nicoletti, F.7
Ruggieri, S.8
Fornai, F.9
-
4
-
-
0025980955
-
The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine- induced degeneration of nigrostriatal dopamine neurons
-
D Ben-Shachar G Eshel JP Finberg MB Youdim 1991 The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons J Neurochem 56 1441 1444
-
(1991)
J Neurochem
, vol.56
, pp. 1441-1444
-
-
Ben-Shachar, D.1
Eshel, G.2
Finberg, J.P.3
Youdim, M.B.4
-
5
-
-
0346849912
-
Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats
-
D Ben-Shachar N Kahana V Kampel A Warshawsky MB Youdim 2004 Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats Neuropharmacology 46 254 263
-
(2004)
Neuropharmacology
, vol.46
, pp. 254-263
-
-
Ben-Shachar, D.1
Kahana, N.2
Kampel, V.3
Warshawsky, A.4
Youdim, M.B.5
-
8
-
-
16244386202
-
Neurologically presenting Wilson's disease: Epidemiology, pathophysiology and treatment
-
GJ Brewer 2005 Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment CNS Drugs 19 185 192
-
(2005)
CNS Drugs
, vol.19
, pp. 185-192
-
-
Brewer, G.J.1
-
9
-
-
0024500857
-
Vitamin e attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats:behavioral and biochemical evidence
-
JL Cadet M Katz V Jackson-Lewis S Fahn 1989 Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats:behavioral and biochemical evidence Brain Res 476 10 15
-
(1989)
Brain Res
, vol.476
, pp. 10-15
-
-
Cadet, J.L.1
Katz, M.2
Jackson-Lewis, V.3
Fahn, S.4
-
10
-
-
0034079858
-
Oxidative stress, mitochondrial respiration, and Parkinson's disease
-
G Cohen 2000 Oxidative stress, mitochondrial respiration, and Parkinson's disease Ann N Y Acad Sci 899 112 120
-
(2000)
Ann N Y Acad Sci
, vol.899
, pp. 112-120
-
-
Cohen, G.1
-
11
-
-
0030605967
-
The effects of iron loading and iron deficiency on the tissue uptake of 64Cu during development in the rat
-
A Crowe EH Morgan 1996 The effects of iron loading and iron deficiency on the tissue uptake of 64Cu during development in the rat Biochim Biophys Acta 1291 53 59
-
(1996)
Biochim Biophys Acta
, vol.1291
, pp. 53-59
-
-
Crowe, A.1
Morgan, E.H.2
-
13
-
-
0024585155
-
Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
-
DT Dexter CJ Carter FR Wells F Javoy-Agid Y Agid A Lees P Jenner CD Marsden 1989b Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease J Neurochem 52 381 389
-
(1989)
J Neurochem
, vol.52
, pp. 381-389
-
-
Dexter, D.T.1
Carter, C.J.2
Wells, F.R.3
Javoy-Agid, F.4
Agid, Y.5
Lees, A.6
Jenner, P.7
Marsden, C.D.8
-
14
-
-
0023653496
-
Increased efflux rather than oxidation is the mechanism of glutathione depletion by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
-
D Di Monte MS Sandy MT Smith 1987 Increased efflux rather than oxidation is the mechanism of glutathione depletion by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) Biochem Biophys Res Commun 148 153 160
-
(1987)
Biochem Biophys Res Commun
, vol.148
, pp. 153-160
-
-
Di Monte, D.1
Sandy, M.S.2
Smith, M.T.3
-
15
-
-
0022525619
-
Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse
-
TN Ferraro GT Golden M DeMattei TA Hare RG Fariello 1986 Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse Neuropharmacology 25 1071 1074
-
(1986)
Neuropharmacology
, vol.25
, pp. 1071-1074
-
-
Ferraro, T.N.1
Golden, G.T.2
Demattei, M.3
Hare, T.A.4
Fariello, R.G.5
-
16
-
-
25644452043
-
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. in vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion
-
S Gal H Zheng M Fridkin MBH Youdim 2005 Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion J Neurochem 95 77 88
-
(2005)
J Neurochem
, vol.95
, pp. 77-88
-
-
Gal, S.1
Zheng, H.2
Fridkin, M.3
Youdim, M.B.H.4
-
17
-
-
0031857636
-
Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine
-
M Gassen A Gross MBH Youdim 1998 Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine Mov Disord 13 242 248
-
(1998)
Mov Disord
, vol.13
, pp. 242-248
-
-
Gassen, M.1
Gross, A.2
Youdim, M.B.H.3
-
18
-
-
0030592141
-
Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction
-
M Gassen Y Glinka B Pinchasi MBH Youdim 1996 Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction Eur J Pharmacol 308 219 225
-
(1996)
Eur J Pharmacol
, vol.308
, pp. 219-225
-
-
Gassen, M.1
Glinka, Y.2
Pinchasi, B.3
Youdim, M.B.H.4
-
19
-
-
0028000825
-
Altered brain metabolism of iron as a cause of neurodegenerative diseases?
-
M Gerlach D Ben-Shachar P Riederer MBH Youdim 1994 Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem 79 793 807
-
(1994)
J Neurochem
, vol.79
, pp. 793-807
-
-
Gerlach, M.1
Ben-Shachar, D.2
Riederer, P.3
Youdim, M.B.H.4
-
20
-
-
0020594156
-
Fe and Cu content in the liver, spleen, kidney and heart of growing rats with variable Fe and Cu supply
-
E Grassmann M Kirchgessner JJ Kim 1983 Fe and Cu content in the liver, spleen, kidney and heart of growing rats with variable Fe and Cu supply Z Ernahrungswiss 22 124 137
-
(1983)
Z Ernahrungswiss
, vol.22
, pp. 124-137
-
-
Grassmann, E.1
Kirchgessner, M.2
Kim, J.J.3
-
22
-
-
0035085603
-
Effects ofR-apomorphine and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss
-
E Grünblatt S Mandel G Maor MBH Youdim 2001 Effects ofR-apomorphine and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss J Neurochem 77 146 156
-
(2001)
J Neurochem
, vol.77
, pp. 146-156
-
-
Grünblatt, E.1
Mandel, S.2
Maor, G.3
Youdim, M.B.H.4
-
23
-
-
0026733994
-
MRI, brain iron and experimental Parkinson's disease
-
S Hall JN Rutledge T Schallert 1992 MRI, brain iron and experimental Parkinson's disease J Neurol Sci 113 198 208
-
(1992)
J Neurol Sci
, vol.113
, pp. 198-208
-
-
Hall, S.1
Rutledge, J.N.2
Schallert, T.3
-
24
-
-
0034796353
-
Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment
-
B Halliwell 2001 Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment Drugs Aging 18 685 716
-
(2001)
Drugs Aging
, vol.18
, pp. 685-716
-
-
Halliwell, B.1
-
27
-
-
0029751104
-
Oxidative stress and the pathogenesis of Parkinson's disease
-
P Jenner CW Olanow 1996 Oxidative stress and the pathogenesis of Parkinson's disease Neurology 47 S161 S170
-
(1996)
Neurology
, vol.47
-
-
Jenner, P.1
Olanow, C.W.2
-
28
-
-
0242684415
-
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
-
D Kaur F Yantiri S Rajagopalan J Kumar JQ Mo R Boonplueang V Viswanath R Jacobs L Yang MF Beal D DiMonte I Volitaskis L Ellerby RA Cherny AI Bush J Anderson 2003 Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease Neuron 37 899 909
-
(2003)
Neuron
, vol.37
, pp. 899-909
-
-
Kaur, D.1
Yantiri, F.2
Rajagopalan, S.3
Kumar, J.4
Mo, J.Q.5
Boonplueang, R.6
Viswanath, V.7
Jacobs, R.8
Yang, L.9
Beal, M.F.10
Dimonte, D.11
Volitaskis, I.12
Ellerby, L.13
Cherny, R.A.14
Bush, A.I.15
Anderson, J.16
-
29
-
-
0033935944
-
Nitric oxide mediated modulation of norepinephrine transport: Identification of a potential target for S-nitrosylation
-
DM Kaye S Gruskin AI Smith MD Esler 2000 Nitric oxide mediated modulation of norepinephrine transport: identification of a potential target for S-nitrosylation Br J Pharmacol 130 1060 1064
-
(2000)
Br J Pharmacol
, vol.130
, pp. 1060-1064
-
-
Kaye, D.M.1
Gruskin, S.2
Smith, A.I.3
Esler, M.D.4
-
30
-
-
0037087748
-
The distribution of copper, zinc- and manganese-superoxide dismutase, and glutathione peroxidase messenger ribonucleic acid in rat basal ganglia
-
G Kunikowska P Jenner 2002 The distribution of copper, zinc- and manganese-superoxide dismutase, and glutathione peroxidase messenger ribonucleic acid in rat basal ganglia Biochem Pharmacol 63 1159 1164
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 1159-1164
-
-
Kunikowska, G.1
Jenner, P.2
-
31
-
-
0030864433
-
Desferrioxamine and vitamin e protect against iron and MPTP-induced neurodegeneration in mice
-
J Lan DH Jiang 1997 Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice J Neural Transm 104 469 481
-
(1997)
J Neural Transm
, vol.104
, pp. 469-481
-
-
Lan, J.1
Jiang, D.H.2
-
33
-
-
0028266425
-
Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys
-
H Mochizuki H Imai K Endo K Yokomizo Y Murata N Hattori Y Mizuno 1994 Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys Neurosci Lett 168 251 253
-
(1994)
Neurosci Lett
, vol.168
, pp. 251-253
-
-
Mochizuki, H.1
Imai, H.2
Endo, K.3
Yokomizo, K.4
Murata, Y.5
Hattori, N.6
Mizuno, Y.7
-
34
-
-
0033669158
-
The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease
-
S Moussaoui MC Obinu N Daniel M Reibaud V Blanchard A Imperato 2000 The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease Exp Neurol 166 235 245
-
(2000)
Exp Neurol
, vol.166
, pp. 235-245
-
-
Moussaoui, S.1
Obinu, M.C.2
Daniel, N.3
Reibaud, M.4
Blanchard, V.5
Imperato, A.6
-
35
-
-
0027991538
-
Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: A histochemical and neurochemical study
-
E Oestreicher GJ Sengstock P Riederer CW Olanow AJ Dunn GW Arendash 1994 Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study Brain Res 660 8 18
-
(1994)
Brain Res
, vol.660
, pp. 8-18
-
-
Oestreicher, E.1
Sengstock, G.J.2
Riederer, P.3
Olanow, C.W.4
Dunn, A.J.5
Arendash, G.W.6
-
36
-
-
0024537271
-
Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum
-
E Pileblad T Magnusson B Fornstedt 1989 Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum J Neurochem 52 978 980
-
(1989)
J Neurochem
, vol.52
, pp. 978-980
-
-
Pileblad, E.1
Magnusson, T.2
Fornstedt, B.3
-
37
-
-
0024557734
-
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
-
P Riederer E Sofic WD Rausch B Schmidt GP Reynolds K Jellinger MBH Youdim 1989 Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains J Neurochem 52 515 520
-
(1989)
J Neurochem
, vol.52
, pp. 515-520
-
-
Riederer, P.1
Sofic, E.2
Rausch, W.D.3
Schmidt, B.4
Reynolds, G.P.5
Jellinger, K.6
Youdim, M.B.H.7
-
38
-
-
0029063832
-
Depletion of copper and manganese in brain after MPTP treatment of mice
-
C Rios R Alvarez-Vega P Rojas 1995 Depletion of copper and manganese in brain after MPTP treatment of mice Pharmacol Toxicol 76 348 352
-
(1995)
Pharmacol Toxicol
, vol.76
, pp. 348-352
-
-
Rios, C.1
Alvarez-Vega, R.2
Rojas, P.3
-
39
-
-
0029670509
-
Thioctic acid does not restore glutathione levels or protect against the potentiation of 6-hydroxydopamine toxicity induced by glutathione depletion in rat brain
-
TA Seaton P Jenner CD Marsden 1996 Thioctic acid does not restore glutathione levels or protect against the potentiation of 6-hydroxydopamine toxicity induced by glutathione depletion in rat brain J Neural Transm 103 315 329
-
(1996)
J Neural Transm
, vol.103
, pp. 315-329
-
-
Seaton, T.A.1
Jenner, P.2
Marsden, C.D.3
-
40
-
-
0028075410
-
Lterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
-
J Sian DT Dexter AJ Lees S Daniel Y Agid F Javoy-Agid P Jenner CD Marsden 1994 lterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia Ann Neurol 36 348 355
-
(1994)
Ann Neurol
, vol.36
, pp. 348-355
-
-
Sian, J.1
Dexter, D.T.2
Lees, A.J.3
Daniel, S.4
Agid, Y.5
Javoy-Agid, F.6
Jenner, P.7
Marsden, C.D.8
-
42
-
-
0028045734
-
Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: Evidence from proton microprobe elemental microanalysis
-
JA Temlett JP Landsberg F Watt GW Grime 1994 Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis J Neurochem 62 134 146
-
(1994)
J Neurochem
, vol.62
, pp. 134-146
-
-
Temlett, J.A.1
Landsberg, J.P.2
Watt, F.3
Grime, G.W.4
-
43
-
-
0027497409
-
The possible role of iron in the etiopathology of Parkinson's disease
-
MB Youdim D Ben-Shachar P Riederer 1993 The possible role of iron in the etiopathology of Parkinson's disease Mov Disord 8 1 12
-
(1993)
Mov Disord
, vol.8
, pp. 1-12
-
-
Youdim, M.B.1
Ben-Shachar, D.2
Riederer, P.3
-
44
-
-
1842608744
-
Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: A lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28
-
MB Youdim G Stephenson D Ben Shachar 2004 Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28 Ann N Y Acad Sci 1012 306 325
-
(2004)
Ann N Y Acad Sci
, vol.1012
, pp. 306-325
-
-
Youdim, M.B.1
Stephenson, G.2
Ben Shachar, D.3
-
46
-
-
11844255676
-
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases
-
H Zheng LM Weiner O Bar-Am S Epsztejn ZI Cabantchik A Warshawsky MB Youdim M Fridkin 2005 Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases Bioorg Med Chem 13 773 778
-
(2005)
Bioorg Med Chem
, vol.13
, pp. 773-778
-
-
Zheng, H.1
Weiner, L.M.2
Bar-Am, O.3
Epsztejn, S.4
Cabantchik, Z.I.5
Warshawsky, A.6
Youdim, M.B.7
Fridkin, M.8
|