Effect of urotensin II on proliferative potential and phosphorylation of extracellular signal-regulated kinase 1/2 adventitial fibroblasts from spontaneously hypertensive rat

Acta Academiae Medicinae Sinicae

Volumn 28, Issue 6, 2006, Pages 776-780

  Dai, Hong Yan ^b   Ge, Zhi Ming ^a   Li, Yong Hong ^a  

^a SHANDONG UNIVERSITY   (China)

^b Qingdao Municipal ^*  (China)

Author keywords

Extracellular signal regulated kinase 1 2; Fibroblasts; Proliferation; Urontensin II

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; THYMIDINE; TRITIUM; UROTENSIN II;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FIBROBLAST; HYPERTENSION; INHIBITION KINETICS; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLASTS; FLAVONOIDS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 3; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RATS; RATS, INBRED SHR; UROTENSINS;

EID: 33846436792     PISSN: 1000503X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Ames RS, Sarau HM, Chambers JK, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature, 1999, 401(16):282-286.
2. Watanabe T, Pakala R, Katagiri T, et al. Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation. J Hypertens, 2001, 19 (12):2191-2196.
3. Chinese source. 2004, 25(6):519-522.
4. Cheung BM, Leung R, Man YB, et al. Plasma concentration of urotensin II is raised in hypertension. J Hypertens, 2004, 22(7):1341-1344.
5. Matsushita M, Shichiri M, Imai T, et al. Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues. J Hypertens, 2001, 19 (12):2185-2190.
6. Bradford MM. A rapid and sensitive method for the quantitation of microgram of protein utilizing the principle of protein dye binding. Anal Biochem, 1976, 72:248-254.
7. Arribas SM, Hillier C, Gonzalez C, et al. Cellular aspects of vascular remodeling in hypertension revealed by confocal microscopy. Hypertension, 1997, 30(6):1455-1464.
8. Zhu DL, Herembert T, Marche P. Increased proliferation of adventitial fibroblasts from spontaneously hypertensive rat aorta. J Hypertens, 1991, 9(12):1161-1168.
9. Coulouarn Y, Lihrmann I, Jegou S, et al. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc Natl Acad Sci, 1998, 95 (26): 15803-15808.
10. Hecquet C, Lefevre G, Valtink M, et al. Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation. Invest Ophthalmol Vis Sci, 2002, 43(9):3091-3098.