Membrane simulations of OpcA: Gating in the loops?

Biophysical Journal

Volumn 92, Issue 2, 2007, Pages

  Bond, Peter J ^a   Derrick, Jeremy P ^b   Sansom, Mark S P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN OPCA; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; NEISSERIA MENINGITIDIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; SIMULATION;

NEGIBACTERIA; NEISSERIA MENINGITIDIS;

EID: 33846434466     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.106.097311     Document Type: Article

References (12)

1. Lee, A. G. 2005. How lipids and proteins interact in a membrane: a molecular approach. Molec. Biosys. 1:203-212.
2. Kim, M., Q. Xu, G. E. Fanucci, and D. S. Cafiso. 2006. Solutes modify a conformational transition in a membrane transport protein. Biophys. J. 90:2922-2929.
3. Yildiz, O., K. R. Vinothkumar, P. Goswami, and W. Kühlbrandt. 2006. Structure of the monomeric outer-membrane porin OmpG in the open and closed conformation. EMBO J. 25:3702-3713.
4. Bond, P. J., and M. S. P. Sansom. 2004. The simulation approach to bacterial outer membrane proteins. Mol. Memb. Biol. 21:151-162.
5. Prince, S. M., M. Achtman, and J. P. Derrick. 2002. Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitides. Proc. Natl. Acad. Sci. USA. 99:3417-3421.
6. Moore, J., S. E. S. Bailey, Z. Benmechernene, C. Tzitzilonis, N. J. E. Griffiths, M. Virji, and J. P. Derrick. 2005. Recognition of saccharides by the OpcA, OpaD, and OpaB outer membrane proteins from Neisseria meningitidis. J. Biol. Chem. 280:31489-31497.
7. Smart, O. S., J. Breed, G. R. Smith, and M. S. P. Sansom. 1997. A novel method for structure-based prediction of ion channel conductance properties. Biophys. J. 72:1109-1126.
8. Bond, P. J., J. D. Faraldo-Gómez, and M. S. P. Sansom. 2002. OmpA: a pore or not a pore? Simulation and modeling studies. Biophys. J. 83:763-775.
9. Hong, H., G. Szabo, and L. K. Tamm. 2006. Electrostatic couplings in OmpA ion-channel gating suggest a mechanism for pore opening. Nat. Chem. Biol. 2:267-635.
10. Conlan, S., Y. Zhang, S. Cheley, and H. Bayley. 2000. Biochemical and biophysical characterization of OmpG: a monomeric porin. Biochem. 39:11845-11854.
11. Tornroth-Horsefield, S., Y. Wang, K. Hedfalk, U. Johanson, M. Karlsson, E. Tajkhorshid, R. Neutze, and P. Kjellbom. 2006. Structural mechanism of plant aquaporin gating. Nature. 439:688-694.
12. Lins, R. D., and T. P. Straatsma. 2001. Computer simulation of the rough lipopolysaccharide membrane of Pseudomonas aeruginosa. Biophys. J. 81:1037-1046.