Are T cells at the origin of B cell lymphomas?

Journal of Theoretical Biology

Volumn 244, Issue 4, 2007, Pages 656-669

  Meyer Hermann, Michael E ^a  

^a FRANKFURT INSTITUTE FOR ADVANCED STUDIES   (Germany)

Author keywords

B cell lymphoma; Germinal centre; Mathematical model; Pathogenesis

Indexed keywords

NUMERICAL METHOD; PATHOGENICITY; TUMOR;

ARTICLE; B CELL LYMPHOMA; CANCER RESEARCH; CARCINOGENESIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL TRANSFORMATION; COMPUTER SIMULATION; DISEASE COURSE; DISEASE MODEL; GERMINAL CENTER; HELPER CELL; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; T LYMPHOCYTE; THEORETICAL MODEL;

APOPTOSIS; B-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CYTOKINES; DENDRITIC CELLS, FOLLICULAR; FEEDBACK; GERMINAL CENTER; HUMANS; LYMPHOMA, B-CELL; MATHEMATICS; MODELS, BIOLOGICAL; T-LYMPHOCYTES, HELPER-INDUCER; TIME FACTORS;

EID: 33846415801     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2006.09.006     Document Type: Article

References (36)

1. Bahler D., and Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc. Natl Acad. Sci. USA 89 (1992) 6770-6774
2. Brent R. Algorithms for Minimization Without Derivatives (1973), Prentice-Hall, Englewood Cliffs, NJ
3. Carrasco Y.R., Fleire S.J., Cameron T., Dustin M.L., and Batista F.D. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 20 5 (2004) 589-599
4. Cattoretti G., Chang C.-C., Cechova K., Zhang J., Ye B., Falini B., Louie D., Offit K., Chaganti R., and Dalla-Favera R. BCL-6 protein is expressed in germinal-center B cells. Blood 86 (1995) 45-53
5. Cerutti A., Zan H., Schaffer A., Bergsagel L., Harindranath N., Max E., and Casali P. Cd40 ligand and appropriate cytokines induce switching to igg, iga, and ige and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal igm+igd+ b cell line. J. Immunol. 160 (1998) 2145-2157
6. Cleary M., Meeker T., Levy S., Lee E., Trela M., Sklar J., and Levy R. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human b cell lymphoma. Cell 44 (1986) 97-106
7. Dogan A., Du M.-Q., Aiello A., Diss T., Ye H.-T., Pan L.-X., and Isaacson P. Follicular lymphomas contain a clonally linked but phenotypically distinct neoplastic b-cell population in the interfollicular zone. Blood 91 (1998) 4708-4714
8. Dunn-Walters D., Thiede C., Alpen B., and Spencer J. Somatic hypermutation and b-cell lymphoma. Philos. Trans. R. Soc. London B 356 (2001) 73-82
9. Goossens T., Klein U., and Küppers R. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl Acad. Sci. USA 95 (1998) 2463-2468
10. Gunven P., Klein G., Klein E., Norin T., and Singh S. Surface immunoglobulins on Burkitt's lymphoma biopsy cells from 91 patients. Int. J. Cancer 25 (1980) 711-719
11. Harris N., Jaffe E., Stein H., et al. A revised European-American classification of lymphoid neoplasm: a proposal from the international lymphoma study group. Blood 84 (1994) 1361-1392
12. Hollowood K., and Macartney J. Cell kinetics of the germinal center reaction-a stathmokinetic study. Eur. J. Immunol. 22 1 (1992) 261-266
13. Iber D., and Maini P. A mathematical model of germinal centre kinetics and affinity maturation. J. Theor. Biol. 219 (2002) 153-175
14. Jaffe, E., Harris, N., Stein, H., Vardiman, J. (Eds.), 2001. Tumours of Haematopoietic and Lymphoid Tissues. IARC Press, Lyon.
15. Jäger, U., Böcskör, S., Le, T., Mitterbauer, G., Bolz, I., Chott, A., Kneba, M., Mannhalter, C., Nadel, B., 2000. Follicular lymphomas' bcl-2/igh junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation. Blood 95, 3520-3529.
16. Küppers R. Mechanisms of b-cell lymphoma pathogenesis. Nat. Rev. Cancer 5 (2005) 251-262
17. Lampert I., Van Noorden S., and Wotherspoon A. Centrocytoid plasma cells of the germinal center. Appl. Immunohistochem. Mol. Morphol. 13 (2005) 124-131
18. Lindhout E., Lakeman A., and de Groot C. Follicular dendritic cells inhibit apoptosis in human B lymphocytes by a rapid and irreversible blockade of preexisting endonuclease. J. Exp. Med. 181 6 (1995) 1985-1995
19. Liu Y., Zhang J., Chan E., and MacLennan I. Sites of specific B cell activation in primary and secondary responses to T-cell-dependent and T-cell-independent antigens. Eur. J. Immunol. 21 (1991) 2951-2962
20. Lossos I., Alizadeh A., Eisen M., Chan W., Brown P., Botstein D., Staudt L., and Levy R. Ongoing immunoglobulin somatic mutation in germinal center b cell-like but not in activated b cell-like diffuse large cell lymphomas. Proc. Natl Acad. Sci. USA 97 (2000) 10209-10213
21. Lougaris V., Badolato R., Ferrari S., and Plebani A. Hyper immunoglobulin m syndrome due to cd40 deficiency: clinical, molecular, and immunological features. Immunol. Rev. 203 (2005) 48-66
22. MacLennan I. Germinal centers. Annu. Rev. Immunol. 12 (1994) 117-139
23. Meyer-Hermann M. A mathematical model for the germinal center morphology and affinity maturation. J. Theor. Biol. 216 3 (2002) 273-300
24. Meyer-Hermann M., and Beyer T. The type of seeder cells determines the efficiency of germinal center reactions. Bull. Math. Biol. 66 1 (2004) 125-141
25. Meyer-Hermann M., and Maini P.K. Back to one-way germinal centers. J. Immunol. 174 (2005) 2489-2493
26. Meyer-Hermann M., Deutsch A., and Or-Guil M. Recycling probability and dynamical properties of germinal center reactions. J. Theor. Biol. 210 (2001) 265-285
27. Meyer-Hermann, M., Maini, P.K., Iber, D., 2006. An analysis of b cell selection mechanisms in germinal centres. Math. Med. Biol. 23, 255-277.
28. Perelson A.S., and Oster G.F. Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. J. Theor. Biol. 81 4 (1979) 645-670
29. Pileri S., Dirnhofer S., Went P., Ascani S., Sabattini E., Marafioti T., Tzankov A., Leoncini L., Falini B., and Zinzani P. Diffuse large b-cell lymphoma: one or more entities? Present controversies and possible tools for its subclassification. Histopathology 41 (2002) 482-509
30. Pileri S., Riccaluga P., Sabattini E., and Zinzani P. Lymphoplasmacytic lymphoma and marginal zone lymphoma: diagnostic challenges. Hematologica 90 (2005) 293
31. Schwarz, Y.X., Yang, M., Qin, D., Wu, J., Jarvis, W.D., Grant, S., Burton, G.F., Szakal, A.K., Tew, J.G., 1999. Follicular dendritic cells protect malignant b cells from apoptosis induced by anti-fas and antineoplastic agents. J. Immunol. 163, 6442-6447.
32. Seitz V., Hummel M., Walter J., and Stein H. Evolution of classic hodgkin lymphoma in correlation to changes in the lymphoid organ structure of vertebrates. Dev. Comp. Immunol. 27 (2003) 43-53
33. Staudt L.M., and Wilson W.H. Focus on lymphomas. Cancer Cell 2 (2002) 363-366
34. Svec A., Velenská Z., and Horejsí V. Expression pattern of adaptor protein pag: correlation between secondary lymphatic follicle and histogenetically related malignant lymphomas. Immunol. Lett. 100 (2005) 94-97
35. Umetsu D., Esserman L., Donlon T., deKruyff R., and Levy R. Induction of proliferation of human follicular (b type) lymphoma cells by cognate interaction with cd4+ t cell clones. J. Immunol. 144 (1990) 2550-2557
36. Verbeke C., Wenthe U., and Zentgraf H. Fas ligand expression in the germinal centre. J. Pathol. 189 (1999) 155-160