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The use of lithium and sodium enolates resulted in recovery of the starting material and a lower yield of 14, respectively
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The use of lithium and sodium enolates resulted in recovery of the starting material and a lower yield of 14, respectively.
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To the best of our knowledge, the solvent has not been used in [2,3]-Wittig rearrangement, probably because the rate of racemization of the carbanion has been thought to be much faster than that of the reaction with an electrophile at temperatures higher than its freezing point (11°C).
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To the best of our knowledge, the solvent has not been used in [2,3]-Wittig rearrangement, probably because the rate of racemization of the carbanion has been thought to be much faster than that of the reaction with an electrophile at temperatures higher than its freezing point (11°C).
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