A Novel Anti-Inflammatory Function of Human Galectin-1: Inhibition of Hematopoietic Progenitor Cell Mobilization

Experimental Hematology

Volumn 35, Issue 2, 2007, Pages 305-313

  Kiss, Judit ^a   Kunstár, Aliz ^a   Fajka Boja, Roberta ^b   Dudics, Valeria ^a,c   Tóvári, József ^d   Légrádi, Ádám ^b   Monostori, Eva ^b   Uher, Ferenc ^a  

^a NATIONAL MEDICAL CENTER   (Hungary)

^b INSTITUTE OF BIOCHEMISTRY   (Hungary)

^c Polyclinic of Hospitaller Brothers of St John of God ^*  (Hungary)

^d NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CD11B ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CYCLOPHOSPHAMIDE; GALECTIN 1; GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD CELL; BONE MARROW; CELL ASSAY; CELL COUNT; CELL NUCLEUS; CELL POPULATION; COLONY FORMING CELL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; FLOW CYTOMETRY; GIEMSA STAIN; GRANULOCYTE; HEMATOPOIETIC STEM CELL; IRRADIATION; LYMPHOCYTE; MALE; MONOCYTE; MONOCYTOSIS; MOUSE; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL MOBILIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL MARKERS; BLOOD CELLS; BONE MARROW CELLS; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CXCL12; COLONY-FORMING UNITS ASSAY; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; GALECTIN 1; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; RECOMBINANT PROTEINS; TIME FACTORS;

ANIMALIA; MAMMALIA; MUS;

EID: 33846393242     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.09.015     Document Type: Article

References (37)

1. Kilpatrick D.C. Animal lectins: a historical introduction and overview. Biochim Biophys Acta 1572 (2002) 187-197
2. Rabinovich G.A. Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy. Cell Death Differ 6 (1999) 711-721
3. Ilarregui J.M., Bianco G.A., Toscano M.A., and Rabinovich G.A. The coming of age of galectins as immunomodulatory agents: impact of these carbohydrate binding proteins in T cell physiology and chronic inflammatory disorders. Ann Rheum Dis 64 Suppl 4 (2005) iv96-iv103
4. Perillo N.L., Pace K.E., Seilhamer J.J., and Baum L.G. Apoptosis of T cells mediated by galectin-1. Nature 378 (1995) 736-739
5. Fajka-Boja R., Szemes M., Ion G., Legradi A., Caron M., and Monostori E. Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines. Immunol Lett 82 (2002) 149-154
6. Ion G., Fajka-Boja R., Kovacs F., et al. Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1. Cell Signal 18 (2006) 1887-1896
7. Matarrese P., Tinari A., Mormone E., et al. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem 280 (2005) 6969-6985
8. Ion G., Fajka-Boja R., Toth G.K., Caron M., and Monostori E. Role of p56lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death. Cell Death Differ 12 (2005) 1145-1147
9. Poirier F., and Robertson E.J. Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development 119 (1993) 1229-1236
10. Offner H., Celnik B., Bringman T.S., Casentini-Borocz D., Nedwin G.E., and Vandenbark A.A. Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J Neuroimmunol 28 (1990) 177-184
11. Rabinovich G.A., Daly G., Dreja H., et al. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 190 (1999) 385-398
12. Santucci L., Fiorucci S., Cammilleri F., Servillo G., Federici B., and Morelli A. Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatology 31 (2000) 399-406
13. Santucci L., Fiorucci S., Rubinstein N., et al. Galectin-1 suppresses experimental colitis in mice. Gastroenterology 124 (2003) 1381-1394
14. Baum L.G., Blackall D.P., Arias-Magallano S., et al. Amelioration of graft versus host disease by galectin-1. Clin Immunol 109 (2003) 295-307
15. La M., Cao T.V., Cerchiaro G., et al. A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol 163 (2003) 1505-1515
16. Panepucci R.A., Siufi J.L., Silva Jr. W.A., et al. Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells. Stem Cells 22 (2004) 1263-1278
17. Kadri T., Lataillade J.J., Doucet C., et al. Proteomic study of Galectin-1 expression in human mesenchymal stem cells. Stem Cells Dev 14 (2005) 204-212
18. Vas V., Fajka-Boja R., Ion G., Dudics V., Monostori E., and Uher F. Biphasic effect of recombinant galectin-1 on the growth and death of early hematopoietic cells. Stem Cells 23 (2005) 279-287
19. Albini A., Paglieri I., Orengo G., et al. The beta-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line. AIDS 11 (1997) 713-721
20. Raso E., Meszaros L., Albini A., and Timar J. A WT1 expressing metastatic human Kaposi sarcoma xenograft model. Pathol Oncol Res 10 (2004) 22-25
21. Gauthier L., Rossi B., Roux F., Termine E., and Schiff C. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc Natl Acad Sci U S A 99 (2002) 13014-13019
22. Bradl H., Wittmann J., Milius D., Vettermann C., and Jack H.M. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate. J Immunol 171 (2003) 2338-2348
23. Molineux G., Pojda Z., Hampson I.N., Lord B.I., and Dexter T.M. Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. Blood 76 (1990) 2153-2158
24. Neben S., Marcus K., and Mauch P. Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 81 (1993) 1960-1967
25. Lapidot T., and Petit I. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 30 (2002) 973-981
26. Papayannopoulou T. Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization. Blood 103 (2004) 1580-1585
27. Pruijt J.F., Verzaal P., van Os R., et al. Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice. Proc Natl Acad Sci U S A 99 (2002) 6228-6233
28. Kollet O., Dar A., Shivtiel S., et al. Osteoclats degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med 12 (2006) 657-664
29. + hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor. Exp Hematol 30 (2002) 176-185
30. Levesque J.P., Hendy J., Takamatsu Y., Williams B., Winkler I.G., and Simmons P.J. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol 30 (2002) 440-449
31. Levesque J.P., Hendy J., Takamatsu Y., Simmons P.J., and Bendall L.J. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 111 (2003) 187-196
32. Wysoczynski M., Reca R., Ratajczak J., et al. Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient. Blood 105 (2005) 40-48
33. Christopherson K.W., Hangoc G., Mantel C.R., and Broxmeyer H.E. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 305 (2004) 1000-1003
34. Heissig B., Hattori K., Dias S., et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109 (2002) 625-637
35. Morrison S.J., Wright D.E., and Weissman I.L. Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Proc Natl Acad Sci U S A 94 (1997) 1908-1913
36. Wright D.E., Cheshier S.H., Wagers A.J., Randall T.D., Christensen J.L., and Weissman I.L. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood 97 (2001) 2278-2285
37. He J., and Baum L.G. Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration. Lab Invest 86 (2006) 578-590