Development of bioadhesive chitosan gels for topical delivery of lidocaine

Scientia Pharmaceutica

Volumn 74, Issue 4, 2006, Pages 209-223

  Varshosaz, Jaleh ^a   Jaffari, Fariba ^a   Karimzadeh, Sara ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antinociception; Chitosan gel; Lidocaine; Transdermal delivery

Indexed keywords

ADHESIVE AGENT; CHITOSAN; CHLORIDE; FORMALDEHYDE; LIDOCAINE; LOCAL ANESTHETIC AGENT; PENETRATION ENHANCING AGENT; PHOSPHATIDYLCHOLINE;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GEL; MOLECULAR WEIGHT; NOCICEPTION; NONHUMAN; RAT; SUSTAINED RELEASE PREPARATION; VISCOSITY;

EID: 33846380682     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.2006.74.209     Document Type: Article

References (20)

1. Aulton, M E, editor. Transdermal drug delivery. In: Pharmaceutics The Science of Dosage Form Design. Second ed. London: Cherchill Livingston, 2002:505- 508.
2. Auner B G, Valenta C. Influence of phloretin on the skin permeation of lidocaine from semisolid preparations. Eur. J. Pharm. Biopharm. 2004;57(2):307-312.
3. Koren G. Topical skin anesthesia. Clin. Dermatol. 1989;7(3):136-141.
4. Smith E W, Maibach H I, editors. Penetration enhancer classification. In: Percutaneous Penetration Enhancers. Boca Raton: CRC Press, 1995:5-20.
5. Hadgraft J, Guy R H, editors. Penetration enhancers and their use in transdermal therapeutic systems. In: Transdermal Drug Delivery. New York: Marcel Dekker, 1989:197-246.
6. Kushla G P, Zatz J L. Evaluation of a noninvasive method for monitoring percutaneous absorption of lidocaine in vivo. Pharm. Res. 1990;7:1033-1037.
7. Kushla G P, Zatz J L, Mills Jr. O H, Berger R S. Noninvasive assessment of anesthetic activity of topical lidocaine formulations. J. Pharm. Sci. 1993;82:1118-1122.
8. Sarpotdar P P, Zatz J L. Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro. J. Pharm. Sci. 1986;75:176-181.
9. Shin S C. Cho C W, Yang K H. Development of lidocaine gels for enhanced local anesthetic action. Int. J. Pharm. 2004;287(1-2):73-78.
10. Wallace M S, Ridgeway B, Jun E, Schulteis G, Rabussay D, Zhang L.Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: An evaluation of skin anesthesia. Reg. Anesth. Pain Med. 2001;26(3):229-238.
11. Bardocci A, Lofoco G, Perdicaro S, Ciucci F, Manna L. Lidocaine 2% gel versus lidocaine 4% unpreserved drops for topical anesthesia in cataract surgery. A randomized controlled trial. Ophthalmol. 2003;110(1):144-149.
12. Kolesnikov Y, Cristea M, Oksman G, Torosjan A, Wilson R. Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects. Brain Res. 2004;1029:217-223.
13. Abbot F V, Franklin K B, Westbrook R F. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain. 1995;60:91-102.
14. Ilium L, Farraj N F, Davis S S. Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. 1994;11:1186-9.
15. Orienti I, Luppi B, Zecchi V. Chitosan and its N-carboxyethyl and N-aminoethyl derivatives as vehicles for topical formulations. J. Cosmet. Sci. 1999 ;50:307-313.
16. Ugweke M I, Verbeke N, Kinget R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J. Pharm. Pharmacel. 2001; 53(1):3-22.
17. Senel S, Ikinci G, Kas S, Yousefi-Rad A, Sargon M F, Hincal A A. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int. J. Pharm. 2000;193:197-203.
18. Rege P R, Shukla D J, Block L H. Chitinosans as tableting excipients for modified release delivers systems. Int. J. Pharm. 1999;181(1):49-60.
19. Ramanatum S, Block L H. The use of chitosan gels matrices for electrically modulated drug delivery. J. Control. Rel. 2001;70(1-2):109-123.
20. Smith J. Chitosan and transdermal drug delivery. Retinoids 2003; 19: 72-75.