Valproic Acid and Bleeding: Caution Required

Annals of Thoracic Surgery

Volumn 83, Issue 2, 2007, Pages 725-

  Veinot, John P ^a   Ruel, Marc ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VALPROIC ACID;

AORTA VALVE REPLACEMENT; AUTOPSY; BLEEDING; CASE REPORT; CAUSE OF DEATH; CORONARY ARTERY BYPASS GRAFT; HUMAN; LETTER; PRIORITY JOURNAL; SEIZURE; SURGICAL PATIENT;

ANIMALS; CARDIAC SURGICAL PROCEDURES; DOGS; HEMORRHAGE; NEUROPROTECTIVE AGENTS; VALPROIC ACID;

EID: 33846380581     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2006.07.058     Document Type: Letter

References (5)

1. Williams J.A., Barreiro C.J., Nwakanma L.U., et al. Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery. Ann Thorac Surg 81 (2006) 2235-2242
2. Pohlmann-Eden B., Peters C.N.A., Wennberg R., et al. Valproate induces reversible factor XIII deficiency with risk of perioperative bleeding. Acta Neurologica Scandinavica 108 (2003) 142-145
3. Carney B.T., and Minter C.L. Is operative blood loss associated with valproic acid?. Analysis of bilateral femoral osteotomy in children with total involvement cerebral palsy. J Pediatr Orthop 25 (2005) 283-285
4. Winter S.L., Kriel R.L., Novacheck T.F., et al. Perioperative blood loss: the effect of valproate. Pediatr Neurol 15 (1996) 19-22
5. Gidal B., Spencer N., Maly M., et al. Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration. Neurology 44 (1994) 1418-1422