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Volumn 48, Issue 8, 2007, Pages 1359-1362

Synthesis of the glucuronide metabolite of ABT-751

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; DRUG METABOLITE; GLUCURONIDE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; TRICHLOROACETIMIDIC ACID;

EID: 33846357024     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.12.114     Document Type: Article
Times cited : (4)

References (26)
  • 1
    • 0026642306 scopus 로고
    • For a review of the importance of glucuronides in regulation of the biological activity of pharmaceuticals, see:
    • For a review of the importance of glucuronides in regulation of the biological activity of pharmaceuticals, see:. Mulder G.J. J. Annu. Rev. Pharmacol. Toxicol. 32 (1992) 25-49
    • (1992) J. Annu. Rev. Pharmacol. Toxicol. , vol.32 , pp. 25-49
    • Mulder, G.J.1
  • 2
    • 0032054655 scopus 로고    scopus 로고
    • For reviews on the chemical synthesis of glucuronides, see:
    • For reviews on the chemical synthesis of glucuronides, see:. Stachulski A.V., and Jenkins G.A. Nat. Prod. Rep. (1998) 173-186
    • (1998) Nat. Prod. Rep. , pp. 173-186
    • Stachulski, A.V.1    Jenkins, G.A.2
  • 4
    • 33846341550 scopus 로고    scopus 로고
    • Yoshino, H.; Ueda, N.; Sugumi, H.; Niijima, J.; Kotake, Y.; Okada, T.; Koyanagi, N.; Watanabe, T.; Asada, M.; Yoshimatsu, K.; Iijima, A.; Nagasu, T.; Tsukahara, K.; Kitoh, K. Sulfonamide Derivatives. U.S. Patent 5,250,549, October 5, 1993.
  • 5
    • 33846349292 scopus 로고    scopus 로고
    • Gordon, G.; Hagey, A. E.; Meek, K. A.; Rosenberg, S. H. Treatment of Cancer in Pediatric Patients. International Patent WO 2005/117903 A1, December 15, 2005.
  • 6
    • 33846359757 scopus 로고    scopus 로고
    • Eisai Co., previously unpublished results.
  • 19
    • 33947461023 scopus 로고
    • Compound 5 can be synthesized on multigram scale from 1,2,3,4-tetra-O-acetyl-β-d-glucuronic acid methyl ester in two steps:
    • Compound 5 can be synthesized on multigram scale from 1,2,3,4-tetra-O-acetyl-β-d-glucuronic acid methyl ester in two steps:. Bollenback G.N., Long J.W., Benjamin D.G., and Lindquist J.A. J. Am. Chem. Soc. 77 (1955) 3310-3315
    • (1955) J. Am. Chem. Soc. , vol.77 , pp. 3310-3315
    • Bollenback, G.N.1    Long, J.W.2    Benjamin, D.G.3    Lindquist, J.A.4
  • 21
    • 33846377884 scopus 로고    scopus 로고
    • note
    • Crystallographic data (excluding structure factors) for the structures in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication numbers CCDC627190. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44(0) 1223 336033 or e-mail: deposit@ccdc.cam.ac.uk].
  • 22
    • 33846386570 scopus 로고    scopus 로고
    • note
    • 6 (39.5 ppm), 125 MHz): δ 169.5, 169.3, 169.0, 167.1, 162.5, 154.9, 146.7, 131.6, 131.4, 129.3, 126.8, 124.5, 117.3, 116.5, 114.2, 111.4, 96.8, 71.0, 70.9, 70.4, 69.0, 67.0, 55.6, 52.6, 20.3, 20.3, 20.2.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.