Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase

Biochemistry

Volumn 46, Issue 2, 2007, Pages 398-405

  Proteasa, Gheorghe ^a   Tahboub, Yahya R ^a   Galijasevic, Semira ^a   Raushel, Frank M ^b   Abu Soud, Husam M ^a,c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; HALIDE MINERALS; HEMODYNAMICS; IRON; NITROGEN OXIDES; STRUCTURAL ANALYSIS; X RAYS;

BINDING SITES; MYELOPEROXIDASE; MYELOPEROXIDASE (MPO); NITRIC OXIDE (NO); PSEUDOHALIDES;

ENZYMES;

BROMINE; ENZYME INHIBITOR; HALIDE; HEME; IODINE; IRON; MYELOPEROXIDASE; NITRIC OXIDE; THIOCYANATE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BLOOD LEVEL; CHEMICAL BINDING; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MICROENVIRONMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; REACTION ANALYSIS; STRUCTURAL PROTEOMICS; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ANIONS; BINDING SITES; CHLORIDES; ENZYME STABILITY; HEME; HUMANS; IRON; KINETICS; MODELS, MOLECULAR; NITRIC OXIDE; PEROXIDASE;

EID: 33846333143     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0609725     Document Type: Article

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