Phenytoin-potentiated hepatotoxicity following acetaminophen overdose? A closer look [3]

Digestive Diseases and Sciences

Volumn 52, Issue 1, 2007, Pages 208-209

  Cook, Matthew D ^a   Williams, Saralyn R ^a   Clark, Richard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; IBUPROFEN; PARACETAMOL; PHENYTOIN;

BRAIN DISEASE; CASE REPORT; DRUG INTOXICATION; DRUG POTENTIATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LETTER; LIVER FAILURE; LIVER INJURY; LIVER TOXICITY; LIVER TRANSPLANTATION; PRIORITY JOURNAL; SELF REPORT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTICONVULSANTS; DRUG SYNERGISM; HUMANS; LIVER FAILURE, ACUTE; OVERDOSE; PHENYTOIN;

EID: 33846327634     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9153-x     Document Type: Letter

References (5)

1. Suchin SM, Wolf DC, Lee Y, Ramaswamy G, Sheiner PA, Facciuto M, Marvin MR, Kim-Schluger L, Lebovics E (2005) Potentiation of acetaminophen hepatotoxiciy by phenytoin, leading to liver transplantation. Dig Dis Sci 50:1836-1838
2. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH (1988) Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976-1985). N Engl J Med 319:1557-1562
3. Bray GP, Harrison PM, O'Grady JG, Tredger JM, Williams R (1992) Long-term anticonvulsant therapyworsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol 11:265-270
4. Tomlinson B, Young RP, Ng MCY, Anderson PJ, Kay R, Critchley JAJH (1996) Selective liver enzyme induction by carbamazepine and phenytoin in Chinese epileptics. Eur J Clin Pharmacol 50:411-415
5. Prescott LF, Critchley JAJH, Balali-Mood M, Pentland B (1981) Effects of microsomal enzyme induction on paracetamol metabolism in man. Br J Clin Pharmacol 12:149-153