Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1

Cancer Chemotherapy and Pharmacology

Volumn 59, Issue 4, 2007, Pages 527-535

  Long, Jason ^a   Manchandia, Tejas ^a   Ban, Kechen ^a   Gao, Shan ^a   Miller, Claudia ^a   Chandra, Joya ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Adaphostin; Catalase; HO 1; Oxidative stress; ROS; Thioredoxin

Indexed keywords

ACETYLCYSTEINE; ADAPHOSTIN; CATALASE; HEAT SHOCK PROTEIN; HEME OXYGENASE 1; PEROXIDE; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE; THIOREDOXIN;

APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; GLIOBLASTOMA; HUMAN; HUMAN CELL; KINETICS; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STRESS; UPREGULATION; WESTERN BLOTTING;

ADAMANTANE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA FRAGMENTATION; FUSION PROTEINS, BCR-ABL; GLIOBLASTOMA; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; HYDROQUINONES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; UP-REGULATION;

EID: 33846288335     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0295-5     Document Type: Article

References (26)

1. Avramis IA, Christodoulopoulos G, Suzuki A, Laug WE, Gonzalez-Gomez I, McNamara G, Sausville EA, Avramis VI (2002) In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines. Cancer Chemother Pharmacol 50:479-489
2. Burton EC, Prados MD (2000) Malignant gliomas. Curr Treat Options Oncol 1:459-468
3. Cao C, Leng Y, Liu X, Yi Y, Li P, Kufe D (2003) Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases. Biochemistry 42:10348-10353
4. Chandra J, Hackbarth J, Le S, Loegering D, Bone N, Bruzek LM, Narayanan VL, Adjei AA, Kay NE, Tefferi A, Karp JE, Sausville EA, Kaufmann SH (2003) Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood 102:4512-4519
5. Chandra J, Tracy J, Loegering D, Flatten K, Verstovsek S, Beran M, Gorre M, Estrov Z, Donato N, Talpaz M, Sawyers C, Bhalla K, Karp J, Sausville E, Kaufmann SH (2005) Adaphostin-induced oxidative stress overcomes bcr/abl mutation-dependent and -independent imatinib resistance. Blood
6. Dasmahapatra G, Nguyen TK, Dent P, Grant S (2006) Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl. Leuk Res
7. Hara E, Takahashi K, Tominaga T, Kumabe T, Kayama T, Suzuki H, Fujita H, Yoshimoto T, Shirato K, Shibahara S (1996) Expression of heme oxygenase and inducible nitric oxide synthase mRNA in human brain tumors. Biochem Biophys Res Commun 224:153-158
8. Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, Yodoi J (1999) Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem 274:27891-27897
9. Hose C, Kaur G, Sausville EA, Monks A (2005) Transcriptional profiling identifies altered intracellular labile iron homeostasis as a contributing factor to the toxicity of adaphostin: decreased vascular endothelial growth factor secretion is independent of hypoxia-inducible factor-1 regulation. Clin Cancer Res 11:6370-6381
10. Hovinga KE, Stalpers LJ, van Bree C, Donker M, Verhoeff JJ, Rodermond HM, Bosch DA, van Furth WR (2005) Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines - a clue to radioresistance? J Neurooncol 74:99-103
11. Kawai H, Nie L, Yuan ZM (2002) Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Mol Cell Biol 22:6079-6088
12. Lee HC, Kim DW, Jung KY, Park IC, Park MJ, Kim MS, Woo SH, Rhee CH, Yoo H, Lee SH, Hong SI (2004) Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line. Int J Mol Med 13:883-887
13. Levitzki A, Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-1788
14. Li J, Lee JM, Johnson JA (2002) Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells. J Biol Chem 277:388-394
15. Maines MD (2005) New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda) 20:382-389
16. Mayerhofer M, Florian S, Krauth MT, Aichberger KJ, Bilban M, Marculescu R, Printz D, Fritsch G, Wagner O, Selzer E, Sperr WR, Valent P, Sillaber C (2004) Identification of heme oxygenase-1 as a novel BCR/ABL-dependent survival factor in chronic myeloid leukemia. Cancer Res 64:3148-3154
17. Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD (2005) Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. J Biol Chem 280:17084-17092
18. Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH (2002) Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99:664-671
19. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271-279
20. Ohgaki H, Kleihues P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64:479-489
21. Riley PA (1994) Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 65:27-33
22. Robinson JP, Bruner LH, Bassoe CF, Hudson JL, Ward PA, Phan SH (1988) Measurement of intracellular fluorescence of human monocytes relative to oxidative metabolism. J Leukoc Biol 43:304-310
23. Sadowska AM, Manuel YKB, De Backer WA (2006) Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther
24. Shanafelt TD, Lee YK, Bone ND, Strege AK, Narayanan VL, Sausville EA, Geyer SM, Kaufmann SH, Kay NE (2005) Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine. Blood 105:2099-2106
25. Svingen PA, Tefferi A, Kottke TJ, Kaur G, Narayanan VL, Sausville EA, Kaufmann SH (2000) Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin Cancer Res 6:237-249
26. Yu C, Rahmani M, Almenara J, Sausville EA, Dent P, Grant S (2004) Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process. Oncogene 23:1364-1376