Methylmercury interaction with lymphocyte cholinergic muscarinic receptors in developing rats

Environmental Research

Volumn 103, Issue 2, 2007, Pages 229-237

  Coccini, Teresa ^a   Randine, Giovanna ^a   Castoldi, Anna F ^a   Acerbi, Davide ^a   Manzo, Luigi ^a,b  

^a IRCCS   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Lactation; Lymphocytes; Mercury; Neurotoxicity; Peripheral markers; Prenatal exposure

Indexed keywords

LIGAND; METHYLMERCURY; MUSCARINIC RECEPTOR; QUINUCLIDINYL BENZILATE; TRITIUM;

BIOMARKER; HEMATOLOGY; HEMOGLOBIN; INHIBITOR; LACTATION; METHYLMERCURY; NEUROLOGY; POLLUTION EFFECT; POLLUTION EXPOSURE; PREGNANCY; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD CONTAMINATION; HUMAN; HUMAN CELL; IMMUNOTOXICITY; LACTATION; LYMPHOCYTE; MALE; MERCURIALISM; NEUROTOXICITY; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; GESTATIONAL AGE; LYMPHOCYTES; MALE; MERCURY; METHYLMERCURY COMPOUNDS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; SPLEEN;

RATTUS;

EID: 33846273413     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2006.05.010     Document Type: Article

References (60)

1. Basu N., Stamler C.J., Loua K.M., and Chan H.M. An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum. Toxicol. Appl. Pharmacol. 205 (2005) 71-76
2. Blakley B.R., Sisodia C.S., and Mukkur T.K. The effect of methylmercury, tetraethyl lead and sodium arsenite on the humoral immune response in mice. Toxicol. Appl. Pharmacol. 52 (1980) 245-254
3. Bylund, D.B., Yamamura, H.I., 1990. Method for receptor binding. In: Yamamura, H.I., Enna, S.J., Kuhar, M.J. (Eds.). Methods in Neurotransmitter Receptor Analysis. New York: Raven Press, 1-36.
4. Caron G.A., Poutala S., and Provost T.T. Lymphocyte transformation induced by inorganic and organic mercury. Int. Arch. Allergy 37 (1970) 76-87
5. Castoldi A.F., Candura S.M., Costa P., Manzo L., and Costa L.G. Interaction of mercury compounds with muscarinic receptor subtypes in the rat brain. Neurotoxicology 17 (1996) 735-742
6. Castoldi A.F., Coccini T., Ceccatelli S., and Manzo L. Neurotoxicity and molecular effects of methylmercury. Brain. Res. Bull. 55 (2001) 197-203
7. Castoldi A.F., Coccini T., Randine G., Hernandez-Viadel M., Felipo V., and Manzo L. Lymphocyte cytochrome oxidase, cyclic GMP and cholinergic muscarinic receptors as peripheral indicators of carbon monoxide neurotoxicity after acute and repeated exposure in the rat brain. Life Sci 78 (2006) 1915-1924
8. Coccini T., Randine G., Candura S.M., Nappi R., Prockop L.D., and Manzo L. Low-level exposure to methylmercury modifies muscarinic cholinergic receptor binding characteristics in rat brain and lymphocytes: physiologic implications and new opportunities in biological monitoring, Environ. Health Perspect. 108 (2000) 29-33
9. Coccini T., Randine G., Castoldi A.F., Balloni L., Baiardi P., and Manzo L. Lymphocyte muscarinic receptors and platelet monoamine oxidase-B as biomarkers of CNS function. Effects of age and gender in healthy humans. Environ. Toxicol. Pharmacol. 19 (2005) 715-720
10. Coccini, T., Randine, G., Castoldi, A.F., Grandjean, P., Ostendorp, G., Heinzow, B., Manzo, L., 2006. Effects of developmental co-exposure to methylmercury and 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB153) on cholinergic muscarinic receptors in rat brain. Neurotoxicology, in press.
11. Colombo M., Hamelin C., Kouassi E., Fournier M., and Bernier J. Differential effects of mercury, lead, and cadmium on IL-2 production by Jurkat T cells. Clin. Immunol. 111 (2004) 311-322
12. Costa L.G., Kaylor G., and Murphy S.D. In vitro and in vivo modulation of cholinergic muscarinic receptors in rat lymphocytes and brain by cholinergic agents. Int. J. Immunopharmacol. 12 (1990) 67-75
13. Costa P., Traver D.J., Auger C.B., and Costa L.G. Expression of cholinergic muscarinic receptor subtypes mRNA in rat blood mononuclear cells. Immunopharmacology 28 (1994) 113-123
14. Dantas D.C.M., and Queiroz M.L.S. Immunoglobulin E and autoantibodies in mercury-exposed workers. Immunopharmacol. Immunotoxicol. 19 (1997) 382-392
15. Eldefrawi M.E., Mansour N.A., and Eldefrawi A.T. Interactions of acetylcholine receptors with organic mercury compounds. Adv. Exp. Med. Biol. 84 (1977) 449-463
16. Ferrero P., Rocca P., Eva C., Benna P., Rebaudengo N., Ravizza L., Genazzani E., and Bergamasco B. An analysis of lymphocyte 3H-N-methyl-scopolamine binding in neurological patients. Evidence of altered binding in Alzheimer's disease. Brain 114 (1991) 1759-1770
17. Fitzgerald B.B., and Costa L.G. Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and in brain areas following repeated organophosphates exposure in rats. Fundam. Appl. Toxicol. 20 (1993) 210-216
18. Fujii T., Watanabe Y., Inoue T., and Kawashima K. Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses. Neurochem. Res. 28 (2003) 423-429
19. Giménez-Llort L., Ahlbom E., Daré E., Vahter M., Ogren A.-O., and Ceccatelli S. Prenatal exposure to methylmercury changes dopamine-modulated motor activity during early ontogeny: age and gender-dependent effects. Environ. Toxicol. Pharmacol. 9 (2001) 61-70
20. Grandjean P., Weihe P., White R.F., Debes F., Araki S., Yokoyama K., Murata K., Sorensen N., Dahl R., and Jorgensen P.J. Cognitive deficit in 7-year-old children with prenatal exposure to methyl-mercury. Neurotoxicol. Teratol. 19 (1997) 417-428
21. Grandjean P., Budtz-Jørgensen E., Jørgensen P.J., and Weihe P. Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ. Health Perspect. 113 (2005) 905-908
22. Hellström-Lindahl E., and Nordberg A. Muscarinic receptor subtypes in subpopulations of human blood mononuclear cells as analyzed by RT-PCR technique. J. Neuoroimmunol. 68 (1996) 139-144
23. Hrdina P.D., Peters D.A., and Singhal R.L. Effects of chronic exposure to cadmium, lead and mercury of brain biogenic amines in the rat. Res. Commun. Chem. Pathol. Pharmacol. 15 (1976) 483-493
24. Ilback N.-G., Sundberg J., and Oskarsson A. Methylmercury exposure via placenta and milk impairs natural killer (NK) cell function in newborn rats. Toxicol. Lett. 58 (1991) 149-158
25. Kawashima K., and Fijii T. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life Sci. 74 (2003) 675-696
26. Kobayashi H., Yuyama A., Matsusaka N., Takeno K., and Yanagiya I. Effects of methylmercury chloride on various cholinergic parameters in vitro. J. Toxicol. Sci. 4 (1979) 351-362
27. Koller L.D., Exon J.H., and Brauner J.A. Methylmercury: decreased antibody formation in mice. Proc. Soc. Exp. Biol. Med. 155 (1977) 602-604
28. Levine, R.R., Birdsall, N.J.M., Nathanson, N.M. (Eds.), 2001. In: The Proceedings of the Ninth International Symposium on Subtypes of Muscarinic Receptors. Life Sci. 68, 2449-2642.
29. Lewandowski T.A., Ponce R.A., Charleston J.S., Hong S., and Faustman E.M. Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicol. Sci. 75 (2003) 124-133
30. Manzo L., Artigas F., Martinez E., Mutti A., Bergamaschi E., Nicotera P., Tonini M., Candura S.M., Ray D.E., and Costa L.G. Biochemical markers of neurotoxicity. A review of mechanistic studies and applications. Hum. Exp. Toxicol. 15 (1996) S20-S35
31. Manzo L., Castoldi A.F., Coccini T., and Prockop L.D. Assessing effects of neurotoxic pollutants by biochemical markers. Environ. Res. Sect. A 85 (2001) 31-36
32. Maslinski W. Cholinergic receptors of lymphocytes. Brain Behav. Immun. 3 (1989) 1-14
33. Masuyama K., Uno K., Minoda R., Eura M., Samejima Y., and Ishikawa T. Muscarinic acetylcholine receptors in patients with Meniere's disease. Acta Otolaryngol. 116 (1996) 369-373
34. Nakatsuru S., Oohashi J., Nozaki H., Nakada S., and Imura N. Effect of mercurials on lymphocyte functions in vitro. Toxicology 36 (1985) 297-305
35. Nomura J., Hosoi T., Okuma Y., and Nomura Y. The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system. Life Sci. 72 (2003) 2121-2126
36. NRC, 2000. National Research Council: Toxicological effects of methylmercury. National Academy Press, Washington, DC, 344.
37. Ortega H.G., Lopez M., Salvaggio J.E., Reimers R., Huang Q., Takaki A., and Arimura A. Effect of methylmercury compounds on the immune system in rat. J. Allergy Clin. Immunol. 93 (1993) 192
38. Ortega H.G., Lopez M., Salvaggio J.E., Reimers R., Hsiao-Lin C., Bollinger J.E., and George W. Lymphocyte proliferative response and tissue distribution of methylmercury sulfide and chloride in exposed rats. J. Toxicol. Environ. Health 50 (1997) 605-616
39. Rabey J.M., Grynberg E., and Graff E. Changes of muscarinic cholinergic binding by lymphocyte in Parkinson's disease with and without dementia. Ann. Neurol. 30 (1991) 847-850
40. Rabey J.M., Lewis A., Graff E., and Korczyn A.D. Decreased (3H) quinuclidinyl benzilate binding to lymphocytes in Gilles de la Tourette syndrome. Biol. Psychiatry 31 (1992) 889-895
41. Ricci A., Amenta F., Bronzetti E., Mannino F., Mariotta S., and Tayebati S.K. Expression of peripheral blood lymphocyte muscarinic cholinergic receptor subtypes in airway hyperresponsiveness. J. Neuroimmunol. 129 (2002) 178-185
42. Rice DC. Evidence for delayed neurotoxicity produced by methylmercury. Neurotoxicology 17 (1996) 583-596
43. Rossi A.D., Ahlbom E., Ogren S.O., Nicotera P., and Beccatelli S. Prenatal exposure to methylmercury alters locomotor activity of male but not female rats. Exp. Brain Res. 117 (1997) 428-436
44. Shenker B.J., Berthold P., Decker S., Mayro J., Rooney C., Vitale L., and Shapiro I.M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. II. Alterations in cell viability. Immunopharmacol. Immunotoxicol. 14 (1992) 555-577
45. Shenker B.J., Rooney C., Vitale L., and Shapiro I.M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes: I. Suppression of T-cell activation. Immunopharmacol. Immunotoxicol. 14 (1992) 539-553
46. Shenker B.J., Berthold P., Rooney C., Vitale L., DeBolt K., and Shapiro I.M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. III. Alterations in B-cell function and viability. Immunopharmacol. Immunotoxicol. 15 (1993) 87-112
47. Shenker B.J., Guo T.L., and Shapiro I.M. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction. Environ. Res. Sect. A 77 (1998) 149-159
48. Shenker B.J., Guo T.L., and Shapiro I.M. Mercury-induced apoptosis in human lymphoid cells: evidence that the apoptotic pathway is mercurial species dependent. Environ. Res. Sect. A 84 (2000) 89-99
49. Shenker B.J., Pankoski L., Zekavat A., and Shapiro I.M. Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status. Antioxid. Redox Signal. 4 (2002) 379-389
50. Silbergeld E.K., Silva I.A., and Nyland J.F. Mercury and autoimmunity: implications for occupational and environmental health. Toxicol. Appl. Pharmacol. 207 (2005) 282-292
51. Tan X.X., Tang C., Castoldi A.F., Manzo L., and Costa L.G. Effects of inorganic and organic mercury on intracellular calcium levels in rat lymphocytes. J. Toxicol. Environ. Health 38 (1993) 159-170
52. Tang J., Carr R.L., and Chambers J.E. The effects of repeated oral exposures to methyl parathion on rat brain cholinesterase and muscarinic receptors during postnatal development. Toxicol. Sci. 76 (2003) 400-406
53. Tayebati S.K., Amenta F., Amici S., El-Assouad D., Gallai V., Ricci A., and Parnetti L. Peripheral blood lymphocytes muscarinic cholinergic receptor subtypes in Alzheimer's disease: a marker of cholinergic dysfunction?. J. Neuroimmunol. 121 (2001) 126-131
54. Thuvander A., Sundberg J., and Oskarsson A. Immunomodulating effects after perinatal exposure to methylmercury in mice. Toxicology 14 (1996) 163-175
55. Tsuzuki Y. Effect of chronic methylmercury exposure on activities of neurotransmitter enzymes in rat cerebellum. Toxicol. Appl. Pharmacol. 60 (1981) 379-381
56. USEPA, 2001. Available: http://www.epa.gov/Region5/air/mercury/understanding.html.
57. Von Burg R., Northington F.K., and Shamoo A. Methylmercury inhibition of rat brain muscarinic receptors. Toxicol. Appl. Pharmacol. 53 (1980) 285-292
58. Wess J. Novel insights into muscarinic acetylcholine receptor function using gene targeting technology. Trends Pharmacol. Sci. 24 (2003) 414-420
59. Wild L.G., Ortega H.G., Lopez M., and Salvaggio J.E. Immune system alteration in the rat after indierct exposure to methylmercury chloride or methylmercury sulfide. Environ. Res. 74 (1997) 34-42
60. Zanoli P., Truzzi C., Veneri C., Braghiroli D., and Baraldi M. Methyl mercury during late gestation affects temporarily the development of the cortical muscarinic receptors in rat offspring. Pharmacol. Toxicol. 75 (1994) 261-264