Rapid test for the evaluation of the activity of the prodrug hydroxymethylnitrofurazone in the processing of Trypanosoma cruzi messenger RNAs

Brazilian Journal of Medical and Biological Research

Volumn 40, Issue 1, 2007, Pages 33-39

  Barbosa, C F ^a   Okuda, E S ^a   Chung, M C ^a   Ferreira, E I ^b   Cicarelli, R M B ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hydroxymethylnitrofurazone; Permeable cells; RNA processing; Trans splicing; Trypanocidal drugs; Trypanosoma cruzi

Indexed keywords

MESSENGER RNA; MESSENGER RNA PRECURSOR; NITROFURAL; PRODRUG; SPLICED LEADER RNA;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CHAGAS DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG APPROVAL; DRUG SCREENING; EPIMASTIGOTE; MOLECULAR MECHANICS; NEMATODE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RNA PROCESSING; SILVER STAINING; STRAIN DIFFERENCE; TRANS SPLICING; TRYPANOSOMA; TRYPANOSOMA CRUZI;

NEMATODA; TRYPANOSOMA CRUZI;

EID: 33846271829     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2007000100005     Document Type: Article

References (20)

1. WHO (World Health Organization). Chagas disease elimination-burden and trends. WHO http://www.who.int; 2003.
2. Macedo AM, Machado CR, Oliveira RP, Pena SD. Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease. Mem Inst Oswaldo Cruz 2004; 99: 1-12.
3. Rodriques CJ, de Castro SL. A critical review on Chagas disease chemotherapy. Mem Inst Oswaldo Cruz 2002; 97: 3-24.
4. Vaidian AK, Weiss LM, Tanowitz HB. Chagas' disease and AIDS. Kinetoplastid Biol Dis 2004; 3: 2-7.
5. de Andrade AL, Zicker F, de Oliveira RM, Almeida SS, Luquetti A, Travassos LR, et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet 1996; 348: 1407-1413.
6. Andrade LO, Machado CR, Chiari E, Pena SID, Macedo AM. Differential tissue distribution of diverse clones of Trypanosoma cruzi in infected mice. Mol Biochem Parasitol 1999; 100: 163-172.
7. Camandaroba EL, Reis EA, Goncalves; MS, Reis MG, Andrade SG. Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain. Rev Soc Bras Med Trop 2003; 36: 201-209.
8. Murta SM, Gazzinelli RT, Brener Z, Romanha AJ. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Mol Biochem Parasitol 1998; 93: 203-214.
9. Andrade ZA, Brener Z. Action of nitrofurazone (5-nitro-2-furalde-hyde-semicarbazone) on the intracellular forms of Trypanosoma cruzi in experimental Chagas' disease. Rev Inst Med Trop São Paulo 1969; 11: 222-228.
10. Henderson GB, Ulrich P, Fairlamb AH, Rosenberg I, Pereira M, Sela M, et al. "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. Proc, Natl Acad Sci U S A 1988; 85: 5374-5378.
11. Croft SL, Seifert K, Duchene M. Antiprotozoal activities of phospholipid analogues. Mol Biochem, Parasitol 2003; 126: 165-172.
12. Urbina JA, Docampo R. Specific chemotherapy of Chagas disease: controversies and advances. Trends Parasitol 2003; 19: 495-501.
13. Chung MC. Planejamento a sintese de pró-fármacos recíprocos de nitrofural e primaquina potencialmente antichagásicos. [Doctoral thesis]. São Paulo: Faculdade cle Ciências Farmacêuticas, USP; 1996.
14. Chung MC, Guido RV, Martinelli TF, Goncalves MF, Polli MC, Botelho KC, et al. Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug. Bioorg Med Chem 2003; 11: 4779-4783.
15. Güido RV, Ferreira EI, Nassute JC, Varanda EA, Chung MC. Diminuição da atividade mutagênica do pró-fármaco, NFOH-121 em relação ao nitrofural (nitrofurazona). Rev Ciên Farm 2001; 22: 319-333.
16. Silva LH, Nussenzweig V. Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia Clin Biol 1953; 20: 191-208.
17. Funayama GK, Prado JC Jr. Estudo dos caracteres de uma amostra boliviana de T. cruzi. Rev Sac Bras Med Trop 1974; 8: 75-81.
18. Ullu E, Tschudi C. Permeable trypanosome cells as a model system for transcription and trans-splicing. Nucleic Acids Res 1990; 16: 3319-3326.
19. Ambrosio DL, Barbosa CF, Vienna VF, Cicarelli RM. Trypanosoma cruzi: establishment of permeable cells for RNA processing analysis with drugs. Mem Inst Oswaldo Cruz 2004; 99: 617-620.
20. Hannon GJ, Maroney PA, Nilson TIN. U small nuclear ribonucleoprotein requirements for nematode cis-and trans-splicing in vitro. J Biol Chem 1991; 266: 22792-22795.