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Van Besien K: The evolving role of autologous and allogeneic stem cell transplantation in follicular lymphoma. Blood Rev 2006, 20:235-244. The most up-to-date and comprehensive review on hematopoietic stem cell transplantation (SCT) in follicular lymphoma.
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Lenz G, Dreyling M, Schiegnitz E, et al.: Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group. Blood 2004, 104:2667-2674.
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Schouten HC, Qian W, Kvaloy S, et al.: High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin's lymphoma: results from the randomized European CUP trial. J Clin Oncol 2003, 21:3918-3927. Report of a randomized trial sponsored by the European Bone Marrow Transplant Registry (EBMTR), comparing conventional chemotherapy with autologous SCT (using unpurged or purged autografts) and demonstrating that autologous SCT prolongs progression-free and overall survival and showing no clear benefit for purging.
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An updated and comprehensive review on hematopoietic SCT in mantle cell lymphoma
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Kiss TL, Mollee P, Lazarus HM, Lipton JH: Stem cell transplantation in mantle cell lymphoma: if, when and how? Bone Marrow Transplant 2005, 36:655-661. An updated and comprehensive review on hematopoietic SCT in mantle cell lymphoma.
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Summary of the current clinical evidence on graft-versus-lymphoma effects
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Grigg A, Ritchie D: Graft-versus-lymphoma effects: clinical review, policy proposals, and immunobiology. Biol Blood Marrow Transplant 2004, 10:579-590. Summary of the current clinical evidence on graft-versus-lymphoma effects.
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Van Besien K, Loberiz FE, Bajorunaite R, et al.: Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. Blood 2003, 10:3521-3529.
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The most recent and excellent review on reduced-intensity regimens in allogeneic stem cell transplantation in lymphoma
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Morris EM, Mackinnon S: Reduced intensity allogeneic stem cell transplantation for low grade non-Hodgkin's lymphoma. Best Pract Res Clin Haematol 2005, 18:129-142. The most recent and excellent review on reduced-intensity regimens in allogeneic stem cell transplantation in lymphoma.
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The most up-to-date and comprehensive review on the role of rituximab in the treatment of follicular lymphoma
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Buske C, Weigert O, Dryling M, et al.: Current status and perspective of antibody therapy in follicular lymphoma. Haematologica 2006, 91:104-112. The most up-to-date and comprehensive review on the role of rituximab in the treatment of follicular lymphoma.
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Feugier P, Van Hoof A, Sebban C, et al.: Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2005, 23:4117-4126. Long-term follow-up of the original GELA study, further confirming that the addition of rituximab to a standard CHOP regimen significantly improves the survival of elderly patients with diffuse large B-cell lymphoma (DLBCL), thus substantiating R-CHOP as the standard therapy for this disease.
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Feugier P, Van Hoof A, Sebban C, et al.: Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2005, 23:4117-4126. Long-term follow-up of the original GELA study, further confirming that the addition of rituximab to a standard CHOP regimen significantly improves the survival of elderly patients with diffuse large B-cell lymphoma (DLBCL), thus substantiating R-CHOP as the standard therapy for this disease.
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13
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33646004738
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Pfreundschuh M, Trumper L, Osterborg A, et al: CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006, 7:379-391. Large international study confirming that in patients below the age of 60 years with DLBCL, the addition of rituximab to CHOP and other more intensified regimens significantly improves disease-free and overall survival, providing the best results ever reported for this group of patients. This study also shows that intensifying chemotherapy while using rituximab produces no benefit.
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Pfreundschuh M, Trumper L, Osterborg A, et al: CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol 2006, 7:379-391. Large international study confirming that in patients below the age of 60 years with DLBCL, the addition of rituximab to CHOP and other more intensified regimens significantly improves disease-free and overall survival, providing the best results ever reported for this group of patients. This study also shows that intensifying chemotherapy while using rituximab produces no benefit.
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14
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Kewalramani T, Zelenetz AD, Nimer SD, et al.: Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma. Blood 2004, 103:3684-3688.
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Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG)
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Lenz G, Dreyling M, Hoster E, et al.: Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol 2005, 23:1984-1992.
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27244452464
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High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
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Prospective phase II trial showing the best treatment results for newly diagnosed mantle cell lymphoma
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Romaguera JE, Fayad L, Rodriguez MA, et al.: High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol 2005, 23:7013-7023. Prospective phase II trial showing the best treatment results for newly diagnosed mantle cell lymphoma.
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Comprehensive review on purging in lymphoma
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Jacobsen E, Freedman A: B-cell purging in autologous stem-cell transplantation for non-Hodgkin lymphoma. Lancet Oncol 2004, 5:711-717. Comprehensive review on purging in lymphoma.
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Ladetto M, Corradini P, Vallet S, et al.: High rate of clinical and molecular remissions in follicular lymphoma patients receiving high-dose sequential chemotherapy and autografting at diagnosis: a multicenter, prospective study by the Gruppo Italiano Trapianto Midollo Osseo (GITMO). Blood 2002, 100:1559-1565.
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Buckstein IR, Imrie K, Spaner D, et al.: Stem cell function and engraftment is not affected by in vivo purging with rituximab for autologous stem cell treatment for patients with low-grade non-Hodgkin's lymphoma. Semin Oncol 1999, 26(suppl 14):115-122.
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22
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33644812283
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Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: In vivo purging with rituximab versus ex vivo purging with CliniMACS CD34+ cell enrichment device
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Randomized study emphasizing the importance of purging in follicular lymphoma
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van Heeckeren WJ, Vollweiler J, Fu P, et al.: Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34+ cell enrichment device. Br J Haematol 2006, 132:42-55. Randomized study emphasizing the importance of purging in follicular lymphoma.
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23
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10744233875
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Quantitative molecular evaluation in autotransplant programs for follicular lymphoma: Efficacy of in vivo purging by rituximab
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Prospective study evaluating the efficacy of in vivo purging with rituximab in advanced follicular lymphoma. This study also compares various PCR methods for the best and most accurate evaluation of the graft
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Galimberti S, Guerrini F, Morabito F, et al.: Quantitative molecular evaluation in autotransplant programs for follicular lymphoma: efficacy of in vivo purging by rituximab. Bone Marrow Transplant 2003, 32:57-63. Prospective study evaluating the efficacy of in vivo purging with rituximab in advanced follicular lymphoma. This study also compares various PCR methods for the best and most accurate evaluation of the graft.
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Magni M, Di Nicola M, Devizzi L, et al.: Successful in vivo purging of CD34-containing peripheral blood harvests in mantle cell and indolent lymphoma: evidence for a role of both chemotherapy and rituximab infusion. Blood 2000, 96:864-869.
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Gianni A, Magni M, Martelli M, et al.: Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen). Blood 2003, 102:749-755. Multicenter, prospective study demonstrating high response rates in newly diagnosed patients with mantle cell lymphoma using high-dose sequential chemotherapy with rituximab for initial debulking and stem cell harvest to attain PCR negativity, with posttransplant consolidation for prolongation of complete remission and elimination of minimal residual disease.
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Gianni A, Magni M, Martelli M, et al.: Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen). Blood 2003, 102:749-755. Multicenter, prospective study demonstrating high response rates in newly diagnosed patients with mantle cell lymphoma using high-dose sequential chemotherapy with rituximab for initial debulking and stem cell harvest to attain PCR negativity, with posttransplant consolidation for prolongation of complete remission and elimination of minimal residual disease.
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26
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A sequence of immuno-chemotherapy with rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma
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Lazzarino M, Arcaini L, Bernasconi P, et al.: A sequence of immuno-chemotherapy with rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma. Br J Haematol 2002, 116:229-235.
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Ghielmini M, Schmitz SF, Cogliatti SB, et al.: Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event free survival and response duration compared with the standard weekly x4 schedule. Blood 2004, 103:4416-4423.
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Hoerr AL, Gao F, Hidalgo J, et al.: Effects of pretransplantation treatment with rituximab on outcomes of autologous stem-cell transplantation for non-Hodgkin's lymphoma. J Clin Oncol 2004, 22:4561-4566.
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Khouri IF, Saliba RM, Hosing C, et al.: Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas. J Clin Oncol 2005, 23:2240-2247. The first study suggesting that the addition of rituximab before and after conventional SCT is associated with superior results in patients with aggressive B-cell non-Hodgkin's lymphoma. The dose of rituximab used in this study was significantly higher than the dose commonly used.
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Khouri IF, Saliba RM, Hosing C, et al.: Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin's lymphomas. J Clin Oncol 2005, 23:2240-2247. The first study suggesting that the addition of rituximab before and after conventional SCT is associated with superior results in patients with aggressive B-cell non-Hodgkin's lymphoma. The dose of rituximab used in this study was significantly higher than the dose commonly used.
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33
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A source of data on the ongoing effect of posttransplant rituximab in eliminating minimal residual disease after autologous SCT
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Brugger W, Hirsch J, Grunebach F, et al.: Rituximab consolidation after high-dose chemotherapy and autologous blood stem cell transplantation in follicular and mantle cell lymphoma: a prospective, multicenter phase II study. Ann Oncol 2004, 15:1691-1698. A source of data on the ongoing effect of posttransplant rituximab in eliminating minimal residual disease after autologous SCT.
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Shimoni A, Hardan I, Avigdor A, et al.: Rituximab reduces relapse risk after allogeneic and autologous stem cell transplantation in patients with high risk aggressive non Hodgkin's lymphoma. Br J Haematol 2003, 122:457-464. First report on posttransplant anti-CD20 in allogeneic transplantation, discussing the benefits of rituximab in allogeneic SCT for lymphoma.
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