High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin's lymphoma: Results from the randomized European CUP trial

Journal of Clinical Oncology

Volumn 21, Issue 21, 2003, Pages 3918-3927

  Schouten, Harry C ^a   Qian, Wendi ^a   Kvaloy, Stein ^a   Porcellini, Adolfo ^a   Hagberg, Hans ^a   Johnsen, Hans Erik ^a   Doorduijn, Jeanette K ^a   Sydes, Matthew R ^a   Kvalheim, Gunnar ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHOP PROTOCOL; CYCLOPHOSPHAMIDE; DOXORUBICIN; PREDNISONE; VINCRISTINE;

ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; B LYMPHOCYTE; CANCER GROWTH; CANCER SURVIVAL; CELL INFILTRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MEGADOSE; FOLLICULAR LYMPHOMA; FOLLOW UP; HUMAN; MULTIPLE CYCLE TREATMENT; NONHODGKIN LYMPHOMA; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT REFUSAL; ADULT; AUSTRALIA; BONE MARROW PURGING; DISEASE FREE SURVIVAL; EUROPE; FEMALE; MALE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PATHOLOGY; PHASE 3 CLINICAL TRIAL; STEM CELL TRANSPLANTATION; SURVIVAL; TUMOR RECURRENCE;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AUSTRALIA; B-LYMPHOCYTES; BONE MARROW PURGING; CYCLOPHOSPHAMIDE; DISEASE-FREE SURVIVAL; DOXORUBICIN; EUROPE; FEMALE; HUMANS; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PREDNISONE; STEM CELL TRANSPLANTATION; SURVIVAL ANALYSIS; VINCRISTINE;

EID: 0642281444     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.10.023     Document Type: Article

References (35)

1. Johnson PW, Rohatiner AZ, Whelan JS, et al: Patterns of survival in patients with recurrent follicular lymphoma: A 20-year study from a single center. J Clin Oncol 13:140-147, 1995
2. Hiddemann W, Unterhalt M: Current status and future perspectives in the treatment of low-grade non-Hodgkin's lymphomas. Blood Rev 8:225-233, 1994
3. Maloney DG, Grillo Lopez AJ, White CA, et al: IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 90:2188-2195, 1997
4. Philip T, Guglielmi C, Hagenbeek A, et al: Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non Hodgkin lymphoma. N Engl J Med 333:1540-1545, 1995
5. Rohatiner A, Johnson P, Price C, et al: Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for recurrent follicular lymphoma. J Clin Oncol 12:1177-1185, 1994
6. Apostolidis J, Gupta RK, Grenzelias D, et al: High-dose therapy with autologous bone marrow support as consolidation of remission in follicular lymphoma: Long-term clinical and molecular follow-up. J Clin Oncol 18:527, 2000
7. Fouillard L, Gorin NC, Laporte JP, et al: Feasibility of autologous bone marrow transplantation for early consolidation of follicular non-Hodgkin's lymphoma. Eur J Haematol 46:279-284, 1991
8. Colombat P, Donadio D, Fouillard L, et al: Value of autologous bone marrow transplantation in follicular lymphoma: A France Autogreffe retrospective study of 42 patients. Bone Marrow Transplant 13:157-162, 1994
9. Linassier C, Fouillard L, Milpied N, et al: Value of autologous bone marrow transplantation (ABMT) in 42 patients with follicular lymphomas responsive to conventional chemotherapy: A "France Autogreffe" study. Cancer Detect Prev 20:11-19, 1996
10. Fouillard L, Laporte JP, Labopin M, et al: Autologous stem-cell transplantation for non-Hodgkin's lymphomas: The role of graft purging and radiotherapy posttransplantation - Results of a retrospective analysis on 120 patients autografted in a single institution. J Clin Oncol 16:2803-2816, 1998
11. Schouten HC, Bierman PJ, Vaughan WP, et al: Autologous bone marrow transplantation in follicular non-Hodgkin's lymphoma before and after histologic transformation. Blood 74:2579-2584, 1989
12. Bierman PJ, Vose JM, Anderson JR, et al: High-dose therapy with autologous hematopoietic rescue for follicular low-grade non-Hodgkin's lymphoma. J Clin Oncol 15:445-450, 1997
13. Freedman AS, Ritz J, Neuberg D, et al: Autologous bone marrow transplantation in 69 patients with a history of low-grade B-cell non-Hodgkin's lymphoma. Blood 77:2524-2529, 1991
14. Freedman AS, Neuberg D, Mauch P, et al: Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood 94:3325-3333, 1999
15. Haas R, Moos M, Karcher A, et al: Sequential high-dose therapy with peripheral-blood progenitor-cell support in low-grade non-Hodgkin's lymphoma. J Clin Oncol 12:1685-1692, 1994
16. Schouten HC, Colombat Ph, Verdonck LF, et al: Autologous bone marrow transplantation for low grade non-Hodgkin's lymphoma: The European Bone Marrow Transplant Group (EBMT) experience, In Dicke KA, Keating A, Gorin NC, et al (eds): Autologous Bone Marrow Transplantation: Proceedings of the sixth international symposium. Arlington, TX, Cancer Treatment Research Education Fund, 1993, pp 71-74
17. Schouten HC, Raemaekers JJ, Kluin-Nelemans HC, et al: High-dose therapy followed by bone marrow transplantation for relapsed follicular non-Hodgkin's lymphoma. Ann Hematol 73:273-277, 1996
18. Horning SJ, Negrin RS, Hoppe RT, et al: High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: Results of a phase II clinical trial. Blood 97:404-409, 2001
19. Gribben JG, Neuberg D, Freedman AS, et al: Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma. Blood 81:3449-3457, 1993
20. Williams CD, Goldstone AH, Pearce RM, et al: Purging of bone marrow in autologous bone marrow transplantation for non-Hodgkin's lymphoma: A case-matched comparison with unpurged cases by the European Blood and Marrow Transplant Lymphoma Registry. J Clin Oncol 14:2454-2464, 1996
21. Kvalheim G, Sorensen O, Fodstad O, et al: Immunomagnetic removal of B-lymphoma cells from human bone marrow: A procedure for clinical use. Bone Marrow Transplant 3:31-41, 1988
22. Straka C, Kroner C, Dorken B, et al: Polymerase chain reaction monitoring shows a high efficacy of clinical immunomagnetic purging in patients with centroblastic-centrocytic non-Hodgkin's lymphoma. Blood 80:2688-2690, 1992
23. Kvalheim G, Wang MY, Pharo A, et al: Purging of tumor cells from leukapheresis products: Experimental and clinical aspects. J Hematother 5:427-436, 1996
24. The Non-Hodgkin's Lymphoma Pathologic Classification Project: National Cancer Institute-sponsored study of classification of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. Cancer 49:2112-2135, 1982
25. A predictive model for aggressive non-Hodgkin's lymphoma: The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 329:987-994, 1993
26. Schouten HC, Colombat P, Verdonck LF, et al: Autologous bone marrow transplantation for low-grade non-Hodgkin's lymphoma: The European Bone Marrow Transplant Group experience - EBMT Working Party for Lymphoma. Ann Oncol 5:147-149, 1994 (suppl 2)
27. Freedman AS, Gribben JG, Neuberg D, et al: High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission. Blood 88:2780-2786, 1996
28. Gallagher CJ, Gregory WM, Jones AE, et al: Follicular lymphoma: prognostic factors for response and survival. J Clin Oncol 4:1470-1480, 1986
29. Gribben JG, Freedman AS, Neuberg D, et al: Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N Engl J Med 325:1525-1533, 1991
30. Van Besien K, Sobocinski KA, Rowlings PA, et al: Allogeneic bone marrow transplantation for low-grade lymphoma. Blood 92:1832-1836, 1998
31. Hiddemann W, Unterhalt M, Wandt H, et al: Myeloablative radiochemotherapy followed by blood-stemcell-transplantation significantly prolongs the disease-free interval in patients with low-grade lymphomas as compared to standard maintenance with interferon alpha: results of a prospective randomized comparison by the German low grade lymphoma study group (GLSG). Blood 94, 1999 (abstr 2715)
32. Colombat P, Foussard C, Bertrand P, et al: Value of autologous stem cell transplantation in first line therapy of follicular lymphoma with high tumor burden: First results of the randomized GOELAMS 064 trial. Blood 98:861a, 2001 (abstr)
33. Berglund A, Enblad G, Carlson K, et al: Long-term follow-up of autologous stem-cell transplantation for follicular and transformed follicular lymphoma. Eur J Haematol 65:17-22, 2000
34. Darrington DL, Vose JM, Anderson JR, et al: Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. J Clin Oncol 12:2527-2534, 1994
35. Decaudin D, Lepage E, Brousse N, et al: Low-grade stage III-IV follicular lymphoma: Multivariate analysis of prognostic factors in 484 patients: A study of the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 17:2499-2505, 1999