Therapy for children with Henoch-Schonlein Purpura nephritis: A systematic review

TheScientificWorldJournal

Volumn 7, Issue , 2007, Pages 20-30

  Zaffanello, Marco ^a   Brugnara, Milena ^a   Franchini, Massimo ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b Verona Hospital   (Italy)

Author keywords

Children; Henoch Schonlein purpura; Nephritis; Therapy

Indexed keywords

ALPHA TOCOPHEROL; ANGIOTENSIN II ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIOXIDANT; AZATHIOPRINE; BLOOD CLOTTING FACTOR 13; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYCLOSPORIN A; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRIDAMOLE; FISH OIL; HEPARIN; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; PREDNISOLONE; PREDNISONE; STEROID; UROKINASE; WARFARIN;

ANAPHYLACTOID PURPURA; CHILDHOOD DISEASE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; DISEASE COURSE; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG MEGADOSE; DRUG PULSE THERAPY; DRUG SUBSTITUTION; FOLLOW UP; HUMAN; KIDNEY DISEASE; LOADING DRUG DOSE; MEDICAL LITERATURE; META ANALYSIS; MONOTHERAPY; MORBIDITY; NEPHRITIS; OPTIMAL DRUG DOSE; PLASMAPHERESIS; PROPHYLAXIS; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; REVIEW; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT;

CHILD; CLINICAL TRIALS; DRUG COMBINATIONS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NEPHRITIS; PHYSICIAN'S PRACTICE PATTERNS; PURPURA, SCHOENLEIN-HENOCH; STEROIDS; TREATMENT OUTCOME;

EID: 33846252770     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2007.23     Document Type: Review

References (60)

1. Davin, J.C. and Weening, J.J. (2003) Diagnosis of Henoch-Schonlein purpura: renal or skin biopsy? Pediatr. Nephrol. 18, 1201-1203.
2. Dawod, S.T. and Akl, K.F. (1990) Henoch-Schoenlein syndrome in Qatar: the effects of steroid therapy and paucity of renal involvement. Ann. Trop. Paediatr. 10, 279-284.
3. Besbas, N., Duzova, A., Topaloglu, R., Gok, F., Ozaltin, F., Ozen, S., and Bakkaloglu, A. (2001) Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schonlein purpura. Clin. Rheumatol. 20, 293-296.
4. Al-Harbi, N.N. (2002) Henoch-Schonlein nephritis complicated with pulmonary hemorrhage but treated successfully. Pediatr. Nephrol. 17, 762-764.
5. Cogar, B.D., Groshong, T.D., Turpin, B.K., and Guajardo, J.R. (2005) Chylothorax in Henoch-Schonlein purpura: a case report and review of the literature. Pediatr. Pulmonol. 39, 563-567.
6. Bruce, R.G., Bishof, N.A., Jackson, E.C., Skinker, D.M., and McRoberts, J.W. (1997) Bilateral ureteral obstruction associated with Henoch-Schoenlein purpura. Pediatr. Nephrol. 11, 347-349.
7. Krause, I., Garty, B.Z., Davidovits, M., Cleper, R., Tamary, H., Rosenmann, E., and Eisenstein, B. (1999) Low serum C3, leukopenia, and thrombocytopenia: unusual features of henoch-schonlein purpura. Eur. J. Pediatr. 158, 906-909.
8. Roberti, I., Reisman, L., and Churg, J. (1993) Vasculitis in childhood. Pediatr. Nephrol. 7, 479-489.
9. Oner, A., Tinaztepe, K., and Erdogan, O. (1995) The effect of triple therapy on rapidly progressive type of Henoch-Schonlein nephritis. Pediatr. Nephrol. 9, 6-10.
10. Whitworth, J.A., Leibowitz, S., Kennedy, M.C., Cameron, J.S., and Chantler, C. (1976) IgA and glomerular disease. Clin. Nephrol. 5, 33-36.
11. Shin, J.I., Park, J.M., Shin, Y.H., Lee, J.S., and Jeong, H.J. (2005) Role of mesangial fibrinogen deposition in the pathogenesis of crescentic Henoch-Schonlein nephritis in children. J. Clin. Pathol. 58, 1147-1151.
12. Algoet, C. and Proesmans, W. (2003) Renal biopsy 2-9 years after Henoch Schonlein purpura. Pediatr. Nephrol. 18, 471-473.
13. Ronkainen, J., Ala-Houhala, M., Huttunen, N.P., Jahnukainen, T., Koskimies, O., Ormala, T., and Nuutinen, M. (2003) Outcome of Henoch-Schoenlein nephritis with nephrotic-range proteinuria. Clin. Nephrol. 60, 80-84.
14. Coppo, R., Gianoglio, B., Porcellini, M.G., and Maringhini, S. (1998) Frequency of renal diseases and clinical indications for renal biopsy in children (report of the Italian National Registry of Renal Biopsies in Children). Group of Renal Immunopathology of the Italian Society of Pediatric Nephrology and Group of Renal Immunopathology of the Italian Society of Nephrology. Nephrol. Dial. Transplant. 13, 293-297.
15. Kaku, Y., Nohara, K., and Honda, S. (1998) Renal involvement in Henoch-Schonlein purpura: a multivariate analysis of prognostic factors. Kidney Int. 53, 1755-1759.
16. Sano, H., Izumida, M., Shimizu, H., and Ogawa, Y. (2002) Risk factors of renal involvement and significant proteinuria in Henoch-Schonlein purpura. Eur. J. Pediatr. 161, 196-201.
17. Chang, W.L., Yang, Y.H., Wang, L.C., Lin, Y.T., and Chiang, B.L. (2005) Renal manifestations in Henoch-Schonlein purpura: a 10-year clinical study. Pediatr. Nephrol. 20, 1269-1272.
18. Robson, W.L. and Leung, A.K. (1994) Henoch-Schonlein purpura. Adv. Pediatr. 41, 163-194.
19. Pillebout, E., Thervet, E., Hill, G., Alberti, C., Vanhille, P., and Nochy, D. (2002) Henoch-Schonlein purpura in adults: outcome and prognostic factors. J. Am. Soc. Nephrol. 13, 1271-1278.
20. Narchi, H. (2005) Risk of long term renal impairment and duration of follow up recommended for Henoch-Schonlein purpura with normal or minimal urinary findings: a systematic review. Arch. Dis. Child. 90, 916-920.
21. Buchanec, J., Galanda, V., Belakova, S., Minarik, M., and Zibolen, M. (1988) Incidence of renal complications in Schonlein-Henoch purpura syndrome in dependence of an early administration of steroids. Int. Urol. Nephrol. 20, 409-412.
22. Reinehr, T., Burk, G., and Andler, W. (2000) Does steroid treatment of abdominal pain prevent renal involvement in Henoch-Schonlein purpura? J. Pediatr. Gastroenterol. Nutr. 31, 323-324.
23. Saulsbury, F.T. (1993) Corticosteroid therapy does not prevent nephritis in Henoch-Schonlein purpura. Pediatr. Nephrol. 7, 69-71.
24. Huber, A.M., King, J., McLaine, P., Klassen, T., and Pothos, M. (2004) A randomized, placebo-controlled trial of prednisone in early Henoch Schonlein purpura. BMC Med. 2, 7.
25. Ronkainen, J., Koskimies, O., Ala-Houhala, M., Antikainen, M., Merenmies, J., Rajantie, J., Ormala, T., Turtinen, J., and Nuutinen, M. (2006) Early prednisone therapy in Henoch-Schonlein purpura: a randomized, double-blind, placebo-controlled trial. J. Pediatr. 149, 241-247.
26. Niaudet, P. and Habib, R. (1998) Methylprednisolone pulse therapy in the treatment of severe forms of Schonlein-Henoch purpura nephritis. Pediatr. Nephrol. 12, 238-243.
27. Ronkainen, J., Autio-Harmainen, H., and Nuutinen, M. (2003) Cyclosporin A for the treatment of severe Henoch-Schonlein glomerulonephritis. Pediatr. Nephrol. 18, 1138-1142.
28. Someya, T., Kaneko, K., Fujinaga, S., Ohtaki, R., Hira, M., and Yamashiro, Y. (2004) Cyclosporine A for heavy proteinuria in a child with Henoch-Schonlein purpura nephritis. Pediatr Int. 46, 111-113.
29. Shin, J.I., Park, J.M., Shin, Y.H., Kim, J.H., Lee, J.S., Kim, P.K., and Jeong, H.J. (2005) Can azathioprine and steroids alter the progression of severe Henoch-Schonlein nephritis in children? Pediatr. Nephrol. 20, 1087-1092.
30. Shin, J.I., Park, J.M., Shin, Y.H., Kim, J.H., Lee, J.S., and Jeong, H.J. (2005) Henoch-Schonlein purpura nephritis with nephrotic-range proteinuria: histological regression possibly associated with cyclosporin A and steroid treatment. Scand. J. Rheumatol. 34, 392-395.
31. Tarshish, P., Bernstein, J., and Edelmann, C.M., Jr. (2004) Henoch-Schonlein purpura nephritis: course of disease and efficacy of cyclophosphamide. Pediatr. Nephrol. 19, 51-56.
32. Rubinger, D., Drukker, A., Shvil, Y., Kopolovic, Y., Friedlaender, M.M., Shalit, M., and Popovtzer, M.M. (1986) Combined cyclophosphamide and corticosteroid-induced remission in severe glomerulopathy associated with systemic vasculitis. Am. J. Nephrol. 6, 346-352.
33. Flynn, J.T., Smoyer, W.E., Bunchman, T.E., Kershaw, D.B., and Sedman, A.B. (2001) Treatment of Henoch-Schonlein purpura glomerulonephritis in children with high-dose corticosteroids plus oral cyclophosphamide. Am. J. Nephrol. 21, 128-133.
34. Tanaka, H., Suzuki, K., Nakahata, T., Ito, E., and Waga, S. (2003) Early treatment with oral immunosuppressants in severe proteinuric purpura nephritis. Pediatr. Nephrol. 18, 347-350.
35. Kawasaki, Y., Suzuki, J., and Suzuki, H. (2004) Efficacy of methylprednisolone and urokinase pulse therapy combined with or without cyclophosphamide in severe Henoch-Schoenlein nephritis: a clinical and histopathological study. Nephrol. Dial. Transplant. 19, 858-864.
36. Iijima, K., Ito-Kariya, S., Nakamura, H., and Yoshikawa, N. (1998) Multiple combined therapy for severe Henoch-Schonlein nephritis in children. Pediatr. Nephrol. 12, 244-248.
37. Prasad, N., Gulati, S., Sharma, R.K., Singh, U., and Ahmed, M. (2004) Pulse cyclophosphamide therapy in steroiddependent nephrotic syndrome. Pediatr. Nephrol. 19, 494-498.
38. Chiurchiu, C., Remuzzi, G., and Ruggenenti, P. (2005) Angiotensin-converting enzyme inhibition and renal protection in nondiabetic patients: the data of the meta-analyses. J. Am. Soc. Nephrol. 16, S58-S63.
39. Remuzzi, A., Perico, N., Sangalli, F., Vendramin, G., Moriggi, M., Ruggenenti, P., and Remuzzi, G. (1999) ACE inhibition and ANG II receptor blockade improve glomerular size-selectivity in IgA nephropathy. Am. J. Physiol. 276, F457-F466.
40. Dzau, V.J., Bernstein, K., Celermajer, D., Cohen, J., Dahlof, B., Deanfield, J., Diez, J., Drexler, H., Ferrari, R., van Gilst, W., Hansson, L., Hornig, B., Husain, A., Johnston, C., Lazar, H., Lonn, E., Luscher, T., Mancini, J., Mimran, A., Pepine, C., Rabelink, T., Remme, W., Ruilope, L., Ruzicka, M., Schunkert, H., Swedberg, K., Unger, T., Vaughan, D., and Weber, M. (2001) The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am. J. Cardiol. 88, 1L-20L.
41. Dixit, M.P., Dixit, N.M., and Scott, K. (2004) Managing Henoch-Schonlein purpura in children with fish oil and ACE inhibitor therapy. Nephrology (Carlton) 9, 381-386.
42. MacKinnon, M., Shurraw, S., Akbari, A., Knoll, G.A., Jaffey, J., and Clark, H.D. (2006) Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease: a systematic review of the efficacy and safety data. Am. J. Kidney Dis. 48, 8-20.
43. Bergstein, J., Leiser, J., and Andreoli, S.P. (1998) Response of crescentic Henoch-Schoenlein purpura nephritis to corticosteroid and azathioprine therapy. Clin. Nephrol. 49, 9-14.
44. Singh, S., Devidayal, Kumar, L., Joshi, K., Minz, R.W., and Datta, U. (2002) Severe Henoch-Schonlein nephritis: resolution with azathioprine and steroids. Rheumatol. Int. 22, 133-137.
45. Foster, B.J., Bernard, C., Drummond, K.N., and Sharma, A.K. (2000) Effective therapy for severe Henoch-Schonlein purpura nephritis with prednisone and azathioprine: a clinical and histopathologic study. J. Pediatr. 136, 370-375.
46. Shin, J.I., Park, J.M., Shin, Y.H., Kim, J.H., Kim, P.K., Lee, J.S., and Jeong, H.J. (2005) Cyclosporin A therapy for severe Henoch-Schonlein nephritis with nephrotic syndrome. Pediatr. Nephrol. 20, 1093-1097.
47. Dal Canton, A., Amore, A., Barbano, G., Coppo, R., Emma, F., Grandaliano, G., Klersy, C., Perfumo, F., Rizzoni, G., Schena, F.P., Sepe, V., and Angiotensin Inhibition Mycophenolate mophetil IgA Nephropathy study investigators (2005) One-year angiotensin-converting enzyme inhibition plus mycophenolate mofetil immunosuppression in the course of early IgA nephropathy: a multicenter, randomised, controlled study. J. Nephrol. 18, 136-140.
48. Filler, G., Hansen, M., LeBlanc, C., Lepage, N., Franke, D., Mai, I., and Feber, J. (2003) Pharmacokinetics of mycophenolate mofetil for autoimmune disease in children. Pediatr. Nephrol. 18, 445-449.
49. Watanabe, T., Takahashi, S., Nakajo, S., and Hamasaki, M. (1996) Pathological improvement of IgA nephropathy and Henoch-Schonlein purpura nephritis with urokinase therapy. Acta Paediatr. Jpn. 38, 622-628.
50. Kawasaki, Y., Suzuki, J., Nozawa, R., Suzuki, S., and Suzuki, H. (2003) Efficacy of methylprednisolone and urokinase pulse therapy for severe Henoch-Schonlein nephritis. Pediatrics 111, 785-789.
51. Kawasaki, Y., Suzuki, J., Murai, M., Takahashi, A., Isome, M., Nozawa, R., Suzuki, S., and Suzuki, H. (2004) Plasmapheresis therapy for rapidly progressive Henoch-Schonlein nephritis. Pediatr. Nephrol. 19, 920-923.
52. Hattori, M., Ito, K., Konomoto, T., Kawaguchi, H., Yoshioka, T., and Khono, M. (1999) Plasmapheresis as the sole therapy for rapidly progressive Henoch-Schonlein purpura nephritis in children. Am. J. Kidney Dis. 33, 427-433.
53. Scharer, K., Krmar, R., Querfeld, U., Ruder, H., Waldherr, R., and Schaefer, F. (1999) Clinical outcome of Schonlein-Henoch purpura nephritis in children. Pediatr. Nephrol. 13, 816-823.
54. Rostoker, G., Desvaux-Belghiti, D., Pilatte, Y., Petit-Phar, M., Philippon, C., Deforges, L., Terzidis, H., Intrator, L., Andre, C., Adnot, S., Bonin, P., Bierling, P., Remy, P., Lagrue, G., Lang, P., and Weil, B. (1994) High-dose immunoglobulin therapy for severe IgA nephropathy and Henoch-Schonlein purpura. Ann. Intern. Med. 120, 476-484.
55. Rostoker, G., Desvaux-Belghiti, D., Pilatte, Y., Petit-Phar, M., Philippon, C., Deforges, L., Terzidis, H., Intrator, L., Andre, C., Adnot, S., et al. (1995) Immunomodulation with low-dose immunoglobulins for moderate IgA nephropathy and Henoch-Schonlein purpura. Preliminary results of a prospective uncontrolled trial. Nephron 69, 327-334.
56. Rostoker, G., Rymer, J.C., Bagnard, G., Petit-Phar, M., Griuncelli, M., and Pilatte, Y. (1998) Imbalances in serum proinflammatory cytokines and their soluble receptors: a putative role in the progression of idiopathic IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis, and a potential target of immunoglobulin therapy? Clin. Exp. Immunol. 114, 468-476.
57. Aries, P.M., Hellmich, B., and Gross, W.L. (2005) Intravenous immunoglobulin therapy in vasculitis: speculation or evidence? Clin. Rev. Allergy Immunol. 29, 237-245.
58. Kaneko, K., Fujii, S., Shono, T., Matsumoto, Y., Arii, N., and Kaneko, K. (2004) Diagnostic value of plasma factor XIII in Henoch-Schonlein purpura. Pediatr. Nephrol. 19, 702-703.
59. Fukui, H., Kamitsuji, H., Nagao, T., Yamada, K., Akatsuka, J., Inagaki, M., Shike, S., Kobayashi, Y., Yoshioka, K., Maki, S., et al. (1989) Clinical evaluation of a pasteurized factor XIII concentrate administration in Henoch-Schonlein purpura. Japanese Pediatric Group. Thromb. Res. 56, 667-675.
60. Erdogan, O., Oner, A., Aydin, A., Isimer, A., Demircin, G., and Bulbul, M. (2003) Effect of vitamin E treatment on the oxidative damage occurring in Henoch-Schonlein purpura. Acta Paediatr. 92, 546-550.