Treatment of Henoch-Schönlein Purpura glomerulonephritis in children with high-dose corticosteroids plus oral cyclophosphamide

American Journal of Nephrology

Volumn 21, Issue 2, 2001, Pages 128-133

  Flynn, Joseph T ^a,b   Smoyer, William E ^a   Bunchman, Timothy E ^a   Kershaw, David B ^a   Sedman, Aileen B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Cyclophosphamide; Glomerulonephritis; Henoch Sch nlein purpura, children; Methylprednisolone; Prednisone

Indexed keywords

ANTIHYPERTENSIVE AGENT; CLONIDINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; NIFEDIPINE; PREDNISONE;

ADOLESCENT; ANAPHYLACTOID PURPURA; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CORTICOSTEROID THERAPY; DISEASE COURSE; DRUG INDUCED DISEASE; DRUG MEGADOSE; FEMALE; GLOMERULONEPHRITIS; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; LEUKOPENIA; MALE; PRIORITY JOURNAL; PROTEINURIA; TREATMENT OUTCOME; VASCULITIS;

ADMINISTRATION, ORAL; ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYCLOPHOSPHAMIDE; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULONEPHRITIS; HUMANS; INJECTIONS, INTRAVENOUS; MALE; METHYLPREDNISOLONE; PREDNISONE; PURPURA, SCHOENLEIN-HENOCH; RETROSPECTIVE STUDIES; SERUM ALBUMIN;

EID: 0035015895     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000046235     Document Type: Article

References (29)

1. Tizard EJ: Henoch-Schönlein purpura. Arch Dis Child 1999;80:380-383.
2. Dillon MJ, Ansell BM: Vasculitis in children and adolescents. Rheum Dis Clin North Am 1995;12:1115-1136.
3. Stewart M, Savage JM, Bell B, McCord B: Long term renal prognosis of Henoch-Schönlein purpura in an unselected childhood population. Eur J Pediatr 1988;147:113-115.
4. White RHR: Henoch-Schönlein nephritis: A disease with significant late sequelae. Nephron 1994;68:1-9.
5. Coppo R, Mazzucco G, Cagnoli L, Lupo A, Schena FB: Long-term prognosis of Henoch-Schönlein nephritis in adults and children. Nephrol Dial Transplant 1996;12:2277-2283.
6. Counahan R, Winterborn MH, White RHR, Heaton JM, Meadow SR, Bluett NH, Swetschin H, Cameron JS, Chantler C: Prognosis of Henoch-Schönlein nephritis in children. Br Med J 1977;ii:11-14.
7. Bunchman TE, Mauer SM, Sibley RK, Veinier RL: Anaphylactoid purpura: Characteristics of 16 patients who progressed to renal failure. Pediatr Nephrol 1988;2:393-397.
8. Goldstein AR, White RHR, Akuse R, Chantler C: Long-term follow-up of childhood Henoch-Schönlein nephritis. Lancet 1992;339:280-282.
9. Austin HA III, Balow JE: Henoch-Schönlein nephritis: Prognostic features and the challenge of therapy. Am J Kidney Dis 1983;2:512-520.
10. Niaudet P, Habib R: Schönlein-Henoch purpura nephritis: Prognostic factors and therapy. Ann Med Interne (Paris) 1994;145:577-580.
11. White RHR, Yoshikawa N: Henoch-Schönlein nephritis; in Holliday MA, Barratt TM, Avner ED (eds): Pediatric Nephrology. Baltimore, Williams & Wilkins, 1994, pp 729-737.
12. National High Blood Pressure Education Program Task Force on Blood Pressure Control in Children: Report of the Second Task Force on Blood Pressure Control in Children - 1987. Pediatrics 1987;79:1-25.
13. Mollica F, Li Volti S, Garozzo R, Russo G: Effectiveness of early prednisonc treatment in preventing the development of nephropathy in anaphylactoid purpura. Eur J Pediatr 1992; 151:140-144.
14. White RHR: Henoch-Schönlein purpura; in Churg A. Churg J (eds): Systemic Vasculitides. New York, Igaku-Shoin, 1991, pp 210-217.
15. Reichel H, Andrassy K, Waldherr R, Bommer J, Ritz E: Rapidly progressive glomerulonephritis in a patient with Henoch-Schönlein purpura: Spontaneous recovery of renal function after six months of maintenance hemodialysis. Clin Nephrol 1995;43:280.
16. Meadow SR, Glasgow EF, White RHR, Moncrieff MW, Cameron JS, Ogg CS: Schönlein-Henoch nephritis. Q J Med 1972;41:241-258.
17. Yoshikawa N, Ito H, Yoshiya K, Nakahara C, Yoshiara S, Hasegawa O, Matsuyama S, Matsuo T: Henoch-Schönlein nephritis and IgA nephropathy in children: A comparison of clinical course. Clin Nephrol 1987;27:233-237.
18. Rose GM, Cole BR, Robson AM: The treatment of severe glomerulopathies in children using high dose intravenous methylprednisolone pulses. Am J Kidney Dis 1981;1:148-156.
19. Niaudet P, Habib R: Methylprednisolone pulse therapy in treatment of severe forms of Schönlein-Henoch purpura nephritis. Pediatr Nephrol 1998;12:238-243.
20. Oner A, Tinaztepe K, Erdogan O: The effect of triple therapy on rapidly progressive type of Henoch-Schönlein nephritis. Pediatr Nephrol 1995;9:6-10.
21. Bergstein J, Leiser J, Andreoli SP: Response of crescentic Henoch-Schönlein purpura nephritis to corticosteroid and azathioprine therapy. Clin Nephrol 1998;49:9-14.
22. Diasio RB, Lo Buglio AF: Immunomodulators: Immunosuppressive agents and immunostimulants; in Hardman JG, Limbird LE (eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics, ed 9. New York, McGraw-Hill, 1996, pp 1291-1308.
23. Taube D, Brown Z, Williams DG: Long-term impairment of suppressor-cell function by cyclophosphamide in minimal-change nephropathy and its association with therapeutic response. Lancet 1981;i:235-238.
24. Feehally J, Beattie TJ, Brcnchley PEC, Coupes BM. Houston IB, Mallick NP, Postlethwaite RJ: Modulation of cellular immune function by cyclophosphamide in children with minimal-change nephropathy. N Engl J Med 1984;310: 415-420.
25. Berns JS, Gaudio KM, Krassner LS, Anderson FP, Durante D, McDonald BM, Siegel NJ: Steroid-responsive nephrotic syndrome of childhood: A long-term study of the clinical course, histopathology, efficacy of cyclophosphamide therapy, and effects on growth. Am J Kidney Dis 1987;9:108-114.
26. Luqmani RA, Palmer RG, Bacon PA: Azathioprine, cyclophosphamide and chlorambucil. Baillières Clin Rheumtaol 1990;4:595-619.
27. Nachman PH, Hogan SL, Jennette JC, Falk RJ: Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996;7:33-39.
28. Facdda R, Pirisi M, Satta A, Bosineu L, Bartoli E: Regression of Henoch-Schönlein disease with intensive immunosuppressive treatment. Clin Pharmacol Ther 1996;60:576-581.
29. Iijima K, Ito-Kaiya S, Nakamura H, Yoshikawa N: Multiple combined therapy for severe Henoch-Schönlein nephritis in children. Pediatr Nephrol 1998;12:244-248.