Altered expression of Smad family members in injured motor neurons of rat

Brain Research

Volumn 1132, Issue 1, 2007, Pages 36-41

  Okuyama, Noriko ^a   Kiryu Seo, Sumiko ^a   Kiyama, Hiroshi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

BMP; Nerve injury; Regeneration; Smad; TGF

Indexed keywords

MESSENGER RNA; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOGLOSSAL NERVE DISEASE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MOTOR NEURON DISEASE; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; AXOTOMY; DOWN-REGULATION; GENE EXPRESSION REGULATION; HYPOGLOSSAL NERVE; HYPOGLOSSAL NERVE DISEASES; IMMUNOHISTOCHEMISTRY; MALE; MOTOR NEURONS; NERVE REGENERATION; RATS; RATS, WISTAR; RETROGRADE DEGENERATION; SMAD PROTEINS; SMAD1 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD8 PROTEIN; UP-REGULATION;

RATTUS;

EID: 33846246414     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.11.019     Document Type: Article

References (21)

1. Honma M., Namikawa K., Mansur K., Iwata T., Mori N., Iizuka H., and Kiyama H. Developmental alteration of nerve injury induced glial cell line-derived neurotrophic factor (GDNF) receptor expression is crucial for the determination of injured motoneuron fate. J. Neurochem. 82 (2002) 961-975
2. Jiang Y., McLennan I.S., Koishi K., and Hendry I.A. Transforming growth factor-beta 2 is anterogradely and retrogradely transported in motoneurons and up-regulated after nerve injury. Neuroscience 97 (2000) 735-742
3. Kiefer R., Lindholm D., and Kreutzberg G.W. Interleukin-6 and transforming growth factor-beta 1 mRNAs are induced in rat facial nucleus following motoneuron axotomy. Eur. J. Neurosci. 5 (1993) 775-781
4. Kiryu S., Morita N., Ohno K., Maeno H., and Kiyama H. Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. Brain Res. Mol. Brain Res. 29 (1995) 147-156
5. Kiryu S., Yao G.L., Morita N., Kato H., and Kiyama H. Nerve injury enhances rat neuronal glutamate transporter expression: identification by differential display PCR. J. Neurosci. 15 (1995) 7872-7878
6. Kretzschmar M., Liu F., Hata A., Doody J., and Massague J. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11 (1997) 984-995
7. Makwana M., and Raivich G. Molecular mechanisms in successful peripheral regeneration. FEBS J. 272 (2005) 2628-2638
8. Miyazawa K., Shinozaki M., Hara T., Furuya T., and Miyazono K. Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells 7 (2002) 1191-1204
9. Moran L.B., and Graeber M.B. The facial nerve axotomy model. Brain Res. Brain Res. Rev. 44 (2004) 154-178
10. Morita N., Takumi T., and Kiyama H. Distinct localization of two serine-threonine kinase receptors for activin and TGF-beta in the rat brain and down-regulation of type I activin receptor during peripheral nerve regeneration. Brain Res. Mol. Brain Res. 42 (1996) 263-271
11. Namikawa K., Honma M., Abe K., Takeda M., Mansur K., Obata T., Miwa A., Okado H., and Kiyama H. Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J. Neurosci. 20 (2000) 2875-2886
12. Rufer M., Flanders K., and Unsicker K. Presence and regulation of transforming growth factor beta mRNA and protein in the normal and lesioned rat sciatic nerve. J. Neurosci. Res. 39 (1994) 412-423
13. Scherer S.S., Kamholz J., and Jakowlew S.B. Axons modulate the expression of transforming growth factor-betas in Schwann cells. Glia 8 (1993) 265-276
14. Setoguchi T., Yone K., Matsuoka E., Takenouchi H., Nakashima K., Sakou T., Komiya S., and Izumo S. Traumatic injury-induced BMP7 expression in the adult rat spinal cord. Brain Res. 921 (2001) 219-225
15. Setoguchi T., Nakashima K., Takizawa T., Yanagisawa M., Ochiai W., Okabe M., Yone K., Komiya S., and Taga T. Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor. Exp. Neurol. 189 (2004) 33-44
16. Snider W.D., Zhou F.Q., Zhong J., and Markus A. Signaling the pathway to regeneration. Neuron 35 (2002) 13-16
17. Song K., Wang H., Krebs T.L., and Danielpour D. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J. 25 (2006) 58-69
18. Tanabe K., Kiryu-Seo S., Nakamura T., Mori N., Tsujino H., Ochi T., and Kiyama H. Alternative expression of Shc family members in nerve-injured motoneurons. Brain Res. Mol. Brain Res. 53 (1998) 291-296
19. ten Dijke P., and Hill C.S. New insights into TGF-beta-Smad signalling. Trends Biochem. Sci. 29 (2004) 265-273
20. Wang P.Y., Koishi K., McGeachie A.B., Kimber M., Maclaughlin D.T., Donahoe P.K., and McLennan I.S. Mullerian inhibiting substance acts as a motor neuron survival factor in vitro. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16421-16425
21. Yao G.L., Kato H., Khalil M., Kiryu S., and Kiyama H. Selective upregulation of cytokine receptor subchain and their intracellular signalling molecules after peripheral nerve injury. Eur. J. Neurosci. 9 (1997) 1047-1054