Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor

American Journal of Obstetrics and Gynecology

Volumn 196, Issue 1, 2007, Pages 37.e1-37.e8

  Smith, Graeme N ^a   Walker, Mark C ^b   Ohlsson, Arne ^c,d   O'Brien, Karel ^c   Windrim, Rory ^d  

^a KINGSTON GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

morbidity; neonate; pregnancy; premature; preterm labor; tocolytic

Indexed keywords

CORTICOSTEROID; GLYCERYL TRINITRATE; PLACEBO;

ADULT; ARTICLE; ATTRIBUTABLE RISK; BIRTH; BRADYCARDIA; BRAIN HEMORRHAGE; CHRONIC LUNG DISEASE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; DYSPNEA; ENCEPHALOMALACIA; FEMALE; FLUSHING; HUMAN; INDUCED HYPOTENSION; LABOR; LOCAL IRRITATION; MAJOR CLINICAL STUDY; MOTHER; MULTICENTER STUDY; NAUSEA AND VOMITING; NECROTIZING ENTEROCOLITIS; NEWBORN MORBIDITY; NEWBORN MORTALITY; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; TOCOLYSIS;

EID: 33846240046     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2006.10.868     Document Type: Article

References (38)

1. Joseph K.S., Kramer M.S., Marcoux S., et al. Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994. N Engl J Med 339 (1998) 1434-1439
2. Bouyer J., and Isenman D. Long term development of preterms: the state of health at age 6 years. In: Papiernik E., Keith L., Bouyer J., Dreyfus J., and Lazar P. (Eds). Effective prevention of preterm birth: the French experience measured at Haguenau. 25(1) ed. (1989), White Plains, New York 195-203
3. Moutquin J.-M. Classification and heterogeneity of preterm birth. BJOG 110 Suppl 20 (2003) 30-33
4. Moutquin J.-M. Socio-economic and psychosocial factors in the management and prevention of preterm labour. BJOG 110 Suppl 20 (2003) 56-60
5. Petrou S. Economic consequences of preterm birth and low birthweight. BJOG 110 Suppl 20 (2003) 17-23
6. Smith G.N. What are the realistic expectations of tocolytics?. BJOG 110 Suppl 20 (2003) 103-106
7. Gyetvai K., Hannah M.E., Hodnett E.D., and Ohlsson A. Tocolytics for preterm labor: a systematic review. Obstet Gynecol 94 (1999) 869-877
8. Lees C., Campbell S., Jauniaux E., et al. Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor. Lancet 343 (1994) 1325-1326
9. Lees C., Lojacono A., Thompson C., et al. Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study. Obstet Gynecol 94 (1999) 403-408
10. Rowlands S., Trudinger B., and Visva-Lingam S. Treatment of preterm cervical dilatation with glyceryl trinitrate, a nitric oxide donor. Aust NZ J Obstet Gynaecol 36 (1996) 377-381
11. Smith G.N., Walker M.C., and McGrath M.J. Randomized, double-blind, placebo controlled trial assessing nitroglycerin as a tocolytic. BJOG 106 (1999) 736-739
12. Heymann M.A., Bootstaylor B., Roman C., et al. Glyceryl trinitrate stops active labour in sheep. In: Moncada S., Feelisch M., and Busse R. (Eds). The biology of nitric oxide. Physiology and clinical aspects (1994), Portland Press, London 201-203
13. Jennings R.W., MacGillivray T.E., and Harrison M.R. Nitric oxide inhibits preterm labour in Rhesus monkeys. J Maternal Fetal Med 2 (1993) 170-175
14. Smith G.N., and Brien J.F. The use of nitroglycerin for uterine relaxation. Obstet Gynecol Survey 53 (1998) 559-565
15. Bisits A., Madsen G., Knox M., et al. The randomized nitric oxide tocolysis trial (RNOTT) for the treatment of preterm labor. Am J Obstet Gynecol 191 (2004) 683-690
16. Sheennan A.T., Dunn M.S., Ohlsson A., Lennox K., and Hoskins E.M. Abnormal pulmonary outcomes in premature infants; prediction from oxygen requirement in the neonatal period. Pediatrics 82 (1988) 527-532
17. Northway W.H., Rosan R.C., and Porter D.Y. Pulmonary disease following respirator therapy of hyaline membrane disease. N Engl J Med 276 (1967) 357-368
18. Bell M.J., Ternberg J.L., Feigin R.D., Keating J.P., Marshall R., Barton L., et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 187 (1978) 1-7
19. Canadian Preterm Labor Investigators Group. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med 327 (1992) 308-312
20. O'Brien P.C., and Fleming T.R. A multiple testing procedure for clinical trials. Biometrics 35 (1979) 549-556
21. Hannah M.E. Search for best tocolytic for preterm labour. Lancet 356 (2000) 699-700
22. Ward R.M., and Beachy J.C. Neonatal complications following preterm birth. BJOG 110 Suppl 20 (2003) 8-16
23. He Q., Sha J., Gu Q., et al. Clinical effect and mechanism of nitroglycerin patch on arresting preterm labor. Zhonghua Fu Chan Ke Za Zhi 37 (2002) 134-135
24. Hannah M.E., Amankwah K., Barret J., et al. The Canadian Consensus on the Use of Tocolytics for Preterm Labour. J SOGC 17 (1995) 1089-1115
25. Wani M.P., Barakzai N., and Graham I. Glyceryl trinitrate vs. ritodrine for the treatment of preterm labor. Int J Gynecol Obstet 85 (2004) 165-167
26. Black R.S., Lees C., Thompson C., Pickles A., and Campbell S. Maternal and fetal cardiovascular effects of transdermal glyceryl trinitrate and intravenous ritodrine. Obstet Gynecol 94 (1999) 572-576
27. El-Sayed Y.Y., Riley E.T., Holbrook H., Cohen S.E., Chitkara U., and Druzin M.L. Randomized comparison of intravenous nitroglycerin and magnesium sulfate for treatment of preterm labour. Obstet Gynecol 93 (1999) 79-83
28. Schleussner E., Moller A., Grob W., et al. Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate. Eur J Obstet Gynecol Reprod Biol 106 (2003) 14-19
29. de Spirlet M., Treluyer J.M., Chevret S., et al. Tocolytic effects of intravenous nitroglycerin. Fundam Clin Pharmacol 18 (2004) 207-213
30. Leszczynska-Gorzelak B., Laskowska M., Marciniak B., and Oleszczuk J. Nitric oxide for treatment of threatend preterm labor. Int J Gynecol Obstet 73 (2001) 201-206
31. Panter K.R., Hannah M.E., Amankwah K.S., Ohlsson A., Jefferies A.L., and Farine D. The effect of indomethacin tocolysis for preterm labour on perinatal outcome: a randomized placebo controlled trial. BJOG 106 (1999) 467-473
32. Bustard M.A., Farley A., Bennett B.M., and Smith G.N. Steady-state maternal and fetal plasma concentrations of glyceryl trinitrate (GTN) in the preterm sheep. Can J Physiol Pharmacol 81 (2003) 884-889
33. Bootstaylor B.S., Roman C., Parer J.T., and Heymann M.A. Fetal and maternal hemodynamic and metabolic effects of maternal nitroglycerin infusions in sheep. Am J Obstet Gynecol 176 (1997) 644-650
34. Bustard M.A., Ryan G., Seaward P.G.R., Salenieks M.E., and Smith G.N. Human maternal and fetal plasma glyceryl trinate concentrations. Am J Obstet Gynecol 189 (2003) 1777-1778
35. Bustard M.A., Farley A.E., and Smith G.N. The pharmacokinetics of glyceryl trinitrate with the use of the in vitro term human placental perfusion setup. Am J Obstet Gynecol 187 (2002) 187-190
36. Kahler C., Schleussner E., Moller A., and Seewald H.J. Nitric oxide donors: effects on fetoplacental blood flow. Eur J Obstet Gynecol Reprod Biol 115 (2004) 10-14
37. Leszczynska-Gorzelak B., Marciniak B., Laskowska M., Slawatynski A., and Oleszczuk J. The influence of transdermal nitroglycerin patches on fetal blood flow parameters in threatened preterm labor. Ginekol Pol 73 (2002) 756-762
38. Luzi G., Caserta G., Iammarino G., Clerici G., and Di Renzo G.C. Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. Ultras Obstet Gynecol 14 (1999) 101-109