Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS

Epilepsia

Volumn 48, Issue 1, 2007, Pages 72-76

  Werner, Tamara ^a,c   Treiss, Irmgard ^a   Kohlmueller, Dirk ^b   Mehlem, Peter ^a   Teich, Martin ^a   Longin, Elke ^a   Gerstner, Thorsten ^a   Koenig, Stephan A ^a   Schulze, Andreas ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Acylcarnitines; Carbamazepine; Carnitine; Children; Dried blood specimens; Electrospray tandem mass spectrometry; Epilepsy; Valproate

Indexed keywords

ACYLCARNITINE; CARBAMAZEPINE; CARNITINE; FLUNARIZINE; PHENOBARBITAL; PHENYTOIN; SULTIAME; TOPIRAMATE; VALPROIC ACID;

ACYLCARNITINE BLOOD LEVEL; ADOLESCENT; ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CARNITINE BLOOD LEVEL; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; EPILEPSY; FEMALE; HIGH RISK PATIENT; HUMAN; LIVER TOXICITY; LONGITUDINAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; SIDE EFFECT; TANDEM MASS SPECTROMETRY; TREATMENT OUTCOME;

ADOLESCENT; ANTICONVULSANTS; CARBAMAZEPINE; CARNITINE; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; EPILEPSY; FEMALE; HEPATITIS, TOXIC; HUMANS; INFANT; LIVER DISEASES; LONGITUDINAL STUDIES; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; VALPROIC ACID;

EID: 33846235102     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00833.x     Document Type: Article

References (29)

1. Bohan TP, Helton E, McDonald I, Konig S, Gazitt S, Sugimoto T, Scheffner D, Cusmano L, Li S, Koch G. (2001) Effect of L-carnitine treatment for valproate-induced hepatotoxicity. Neurology 56:1405-1409.
2. Bohles H, Richter K, Wagner-Thiessen E, Schafer H. (1982) Decreased serum carnitine in valproate induced Reye syndrome. European Journal of Pediatrics 139:185-186.
3. Bryant AE, Dreifuss FE. (1996) Valproic acid hepatic fatalities. III. U.S. experience since 1986. Neurology 46:465-469.
4. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, Couceiro J, Camina F, Rodriguez-Segade S. (1998) Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital. Journal of Child Neurology 13:546-549.
5. Coulter DL. (1984) Carnitine deficiency: a possible mechanism for valproate hepatotoxicity. Lancet 1:689.
6. De Vivo DC, Bohan TP, Coulter DL, Dreifuss FE, Greenwood RS, Nordli DR Jr, Shields WD, Stafstrom CE, Tein I. (1998) L-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia 39:1216-1225.
7. Hiraoka A, Arato T, Tominaga I. (1997) Reduction in blood free carnitine levels in association with changes in sodium valproate (VPA) disposition in epileptic patients treated with VPA and other anti-epileptic drugs. Biological and Pharmaceutical Bulletin 20:91-93.
8. Kibayashi M, Nagao M, Chiba S. (1999) Influence of valproic acid on the expression of various acyl-CoA dehydrogenases in rats. Pediatrics International 41:52-60.
9. Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R. (1994) Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities. Epilepsia 35:1005-1015.
10. Kossak BD, Schmidt-Sommerfeld E, Schoeller DA, Rinaldo P, Penn D, Tonsgard JH. (1993) Impaired fatty acid oxidation in children on valproic acid and the effect of L-carnitine. Neurology 43:2362-2368.
11. Laub MC, Paetzke-Brunner I, Jaeger G. (1986) Serum carnitine during valproic acid therapy. Epilepsia 27:559-562.
12. Matsuda I, Ohtani Y. (1986) Carnitine status in Reye and Reye-like syndromes. Pediatric Neurology 2:90-94.
13. Millington DS, Bohan TP, Roe CR, Yergey AL, Liberato DJ. (1985) Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry. Clinica Chimica Acta 145:69-76.
14. Morita J, Yuge K, Yoshino M. (1986) Hypocarnitinemia in the handicapped individuals who receive a polypharmacy of antiepileptic drugs. Neuropediatrics 17:203-205.
15. Murphy JV, Groover RV, Hodge C. (1993) Hepatotoxic effects in a child receiving valproate and carnitine. Journal of Pediatrics 123:318-320.
16. Murphy JV, Marquardt KM, Shug AL. (1985) Valproic acid associated abnormalities of carnitine metabolism. Lancet 1:820-821.
17. Ohtani Y, Endo F, Matsuda I. (1982) Carnitine deficiency and hyperammonemia associated with valproic acid therapy. Journal of Pediatrics 101:782-785.
18. Riva R, Albani F, Gobbi G, Santucci M, Baruzzi A. (1993) Carnitine disposition before and during valproate therapy in patients with epilepsy. Epilepsia 34:184-187.
19. Rodriguez-Segade S, de la Pena CA, Tutor JC, Paz JM, Fernandez MP, Rozas I, Del RR. (1989) Carnitine deficiency associated with anticonvulsant therapy. Clinica Chimica Acta 181:175-181.
20. Saudubray JM, Martin D, de Lonlay P, Touati G, Poggi-Travert F, Bonnet D, Jouvet P, Boutron M, Slama A, Vianey-Saban C, Bonnefont JP, Rabier D, Kamoun P, Brivet M. (1999) Recognition and management of fatty acid oxidation defects: a series of 107 patients. Journal of Inherited Metabolic Disease 22:488-502.
21. Schmidt-Sommerfeld E, Penn D, Rinaldo P, Kossak D, Li BU, Huang ZH, Gage DA. (1992) Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method. Pediatric Research 31:545-551.
22. Schulze A, Lindner M, Kohlmuller D, Olgemoller K, Mayatepek E, Hoffmann GF. (2003a) Expanded newborn screening for inborn errors of metabolism by electrospray ionization-tandem mass spectrometry: results, outcome, and implications. Pediatrics 111:1399-1406.
23. Schulze A, Schmidt C, Kohlmuller D, Hoffmann GF, Mayatepek E. (2003b) Accurate measurement of free carnitine in dried blood spots by isotope-dilution electrospray tandem mass spectrometry without butylation. Clinica Chimica Acta 335:137-145.
24. Silva MF, Jakobs C, Duran M, De Almeida IT, Wanders RJ. (2001a) Valproate induces in vitro accumulation of long-chain fatty acylcarnitines. Molecular Genetics and Metabolism 73:358-361.
25. Silva MF, Selhorst J, Overmars H, van Gennip AH, Maya M, Wanders RJ, De Almeida IT, Duran M. (2001b) Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS. Clinical Biochemistry 34:635-638.
26. Van Wouwe JP. (1995) Carnitine deficiency during valproic acid treatment. International Journal for Vitamin and Nutrition Research 65:211-214.
27. Verrotti A, Greco R, Morgese G, Chiarelli F. (1999) Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. International Journal of Clinical and Laboratory Research 29:36-40.
28. Zelnik N, Fridkis I, Gruener N. (1995) Reduced carnitine and antiepileptic drugs: cause relationship or co-existence? Acta Paediatrica 84:93-95.
29. Ziadeh R, Hoffman EP, Finegold DN, Hoop RC, Brackett JC, Strauss AW, Naylor EW. (1995) Medium chain acyl-CoA dehydrogenase deficiency in Pennsylvania: neonatal screening shows high incidence and unexpected mutation frequencies. Pediatric Research 37:675-678.