Reduction in blood free carnitine levels in association with changes in sodium valproate (VPA) disposition in epileptic patients treated with VPA and other anti-epileptic drugs

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 1, 1997, Pages 91-93

  Hiraoka, Atsushi ^a   Arato, Teruyo ^b   Tominaga, Itaru ^c  

^a KYORIN UNIVERSITY   (Japan)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION CHIBA MEDICAL CENTER   (Japan)

Author keywords

anti epileptic drug; free carnitine; level dose ratio; side effect; sodium valproate

Indexed keywords

CARBAMAZEPINE; CARNITINE; DRUG METABOLIZING ENZYME; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ADULT; ARTICLE; BLOOD LEVEL; CARNITINE DEFICIENCY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DISPOSITION; DRUG METABOLISM; ENZYME INDUCTION; EPILEPSY; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION;

EID: 0031032405     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.91     Document Type: Article

References (20)

1. A summary of this paper was presented at the 6th Clinical Pharmacy Symposium (Nagasaki, June 1996).
2. Gerber N., Dickinson R. G., Harland R. C., Lynn R. K., Houghton L. D., J. Pediatr., 95, 142-144 (1979).
3. Bohles H., Richter K., Wagner-Thiessen E., Schafer H., Eur. J. Pediatr., 139, 185-186 (1982).
4. LeBihan G., Bourreille J., Sampson M., Leroy J., Szekely A. M., Coquerel A., Lancet, ii, 1288-1289 (1980).
5. Ohtani Y., Endo F., Matsuda I., J. Pediatr., 101, 782-785 (1982).
6. Coulter D. L., Allen R. J., J. Pediatr., 99, 317-319 (1981).
7. Jaeken J., Corbeel L., Casaer P., Carchon H., Eggermont E., Eeckels R., Lancet, ii, 617 (1977).
8. Tein I., DiMauro S., Xie Z. W., DeVivo D. C. Pediatr. Res., 34, 281-287 (1993).
9. Kriel R. L., Cloyd J. C., Green K. H., Ronald J. S., Lawrence A. L., Rose E., Ann. Neurol., 6, 179 (1979).
10. Miyakoshi M., Kakegawa N., Sagisaka M., Kiyono M., No To Hattatsu, 11, 567-576 (1979).
11. Bowdle T. A., Levy R. H., Culter R. E., Clin. Pharmacol. Therap., 26, 629-634 (1979).
12. Hiraoka A., Miura I., Akai J., Tominaga I., Hattori M., Machida S., Arato T., J. Anal. Bio-Sci., 17, 274-279 (1994).
13. Wan L., Hubbard R. W., Clin. Chem., 41, S159 (1995).
14. Shihabi Z. K., Oles K. S., McCormick C. P., Penry J. K., Clin. Chem., 38, 1414-1417 (1992).
15. Schobben F., van der Klejin E., Gabressls F. J. M., Eur. J. Clin. Pharmacol., 8, 97-105 (1975).
16. Bruni J., Wilder B. J., Willmore L. J., Perchalski M., Villarreal H. G., Clin. Pharmacol. Therap., 24, 324-332 (1978).
17. Grusky J. A., Rosenberg L. E., Pediatr. Res., 13, 475 (1979).
18. Becker C. M., Harris R. A., Arch. Biochem. Biophys., 223, 381-392 (1983).
19. Bieber L. L., Emaus R., Valkner K., Farrel S., Fed. Proc., 41, 2858-2862 (1982).
20. Tada A., Shinshu Med. J., 41, 115-129 (1993).