Hyperoxic conditions inhibit airway smooth muscle myosin phosphatase in rat pups

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 292, Issue 1, 2007, Pages

  Smith, Paul G ^a,b   Dreshaj, Albana ^a   Chaudhuri, Subhendu ^a   Onder, Baran M ^a   Mhanna, Maroun J ^a   Martin, Richard J ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dept of Pediatrics ^*  (United States)

Author keywords

Airway hyperresponsiveness; Bethanechol; Myosin binding subunit; Trachealis muscle

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BETHANECHOL; MYOSIN LIGHT CHAIN; MYOSIN PHOSPHATASE; OXYGEN; PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING MUSCLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPEROXIA; MUSCLE CONTRACTILITY; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE;

ANIMALS; ANIMALS, NEWBORN; BRONCHIAL HYPERREACTIVITY; DISEASE MODELS, ANIMAL; HUMANS; HYPEROXIA; INFANT, NEWBORN; MUSCLE, SMOOTH; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TRACHEA;

EID: 33846232733     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00460.2005     Document Type: Article

References (26)

1. Agani FH, Kuo NT, Chang CH, Dreshaj IA, Farver CF, Krause JE, Ernsberger P, Haxhiu MA, Martin RJ. Effect of hyperoxia on substance P expression and airway reactivity in the developing lung. Am J Physiol Lung Cell Mol Physiol 273: L40-L45, 1997.
2. 2 exposure enhances vascular and airway smooth muscle contraction in the newborn but not adult rat. J Appl Physiol 94: 2303-2312, 2003.
3. Denis D, Fayon MJ, Berger P, Molimard M, De Lara MT, Roux E, Marthan R. Prolonged moderate hyperoxia induces hyperresponsiveness and airway inflammation in newborn rats. Pediatr Res 50: 515-519, 2001.
4. Dirksen WP, Vladic F, Fisher SA. A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch. Am J Physiol Cell Physiol 278: C589-C600, 2000.
5. Haystead TA. ZIP kinase, a key regulator of myosin protein phosphatase 1. Cell Signal 17: 1313-1322, 2005.
6. Hershenson MB, Aghili S, Punjabi N, Hernandez C, Ray DW, Garland A, Glagov S, Solway J. Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats. Am J Physiol Lung Cell Mol Physiol 262: L263-L269, 1992.
7. Hori M, Karaki H. Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle. Life Sci 62: 1629-1633, 1998.
8. Iben SC, Dreshaj IA, Farver CF, Haxhiu MA, Martin RJ. Role of endogenous nitric oxide in hyperoxia-induced airway hyperreactivity in maturing rats. J Appl Physiol 89: 1205-1212, 2000.
9. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163: 1723-1729, 2001.
10. Khatri JJ, Joyce KM, Brozovich FV, Fisher SA. Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation. J Biol Chem 276: 37250-37257, 2001.
11. Knox AJ, Tattersfield AE. Airway smooth muscle relaxation. Thorax 50: 894-901, 1995.
12. Komatsu S, Yano T, Shibata M, Tuft RA, Ikebe M. Effects of the regulatory light chain phosphorylation of myosin II on mitosis and cytokinesis of mammalian cells. J Biol Chem 275: 34512-34520, 2000.
13. Mai XM, Gaddlin PO, Nilsson L, Finnstrom O, Bjorksten B, Jenmalm MC, Leijon I. Asthma, lung function and allergy in 12-year-old children with very low birth weight: a prospective study. Pediatr Allergy Immunol 14: 184-192, 2003.
14. Mhanna MJ, Dreshaj IA, Haxhiu MA, Martin RJ. Mechanism for substance P-induced relaxation of precontracted airway smooth muscle during development. Am J Physiol Lung Cell Mol Physiol 276: L51-L56, 1999.
15. Mhanna MJ, Haxhiu MA, Jaber MA, Walenga RW, Chang CH, Liu S, Martin RJ. Hyperoxia impairs airway relaxation in immature rats via a cAMP-mediated mechanism. J Appl Physiol 96: 1854-1860, 2004.
16. Murthy KS, Zhou H, Grider JR, Makhlouf GM. Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA. Am J Physiol Gastrointest Liver Physiol 284: G1006-G1016, 2003.
17. Niiro N, Koga Y, Ikebe M. Agonist-induced changes in the phosphorylation of the myosin-binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle. Biochem J 369: 117-128, 2003.
18. Northway WH Jr. Bronchopulmonary dysplasia: then and now. Arch Dis Child 65: 1076-1081, 1990.
19. Northway WH Jr. Bronchopulmonary dysplasia: thirty-three years later. Pediatr Pulmonol Suppl 23: 5-7, 2001.
20. Payne MC, Zhang HY, Shirasawa Y, Koga Y, Ikebe M, Benoit JN, Fisher SA. Dynamic changes in expression of myosin phosphatase in a model of portal hypertension. Am J Physiol Heart Circ Physiol 286: H1801-H1810, 2004.
21. Skloot G, Permutt S, Togias A. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest 96: 2393-2403, 1995.
22. Smith PG, Roy C, Fisher S, Huang QQ, Brozovich F. Selected contribution: mechanical strain increases force production and calcium sensitivity in cultured airway smooth muscle cells. J Appl Physiol 89: 2092-2098, 2000.
23. Solway J, Hershenson MB. Structural and functional abnormalities of the airways of hyperoxia-exposed immature rats. Chest 107: 89S-93S, 1995.
24. 2+ sensitivity of smooth muscle and non-muscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
25. Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, Lincoln TM, Mendelsohn ME. Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Ialpha. Science 286: 1583-1587, 1999.
26. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994, 1997.