Pathophysiology of hypertrophic cardiomyopathy determines its medical treatment

Anadolu Kardiyoloji Dergisi

Volumn 6, Issue SUPPL. 2, 2006, Pages 9-17

  Musat, Dan ^a   Sherrid, Mark V ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Department of Clinical Medicine ^*  (United States)

Author keywords

blockers; Disopyramide; Hypertrophic cardiomyopathy; Obstructed hypertrophic cardiomyopathy; Pharmacologic treatment; Systolic anterior motion; Verapamil

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIGOXIN; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISOPYRAMIDE; DIURETIC AGENT; DOBUTAMINE; DOPAMINE; ESMOLOL; INOTROPIC AGENT; METOPROLOL; NIFEDIPINE; NITRATE; PHENYLEPHRINE; VASODILATOR AGENT; VERAPAMIL;

BETA ADRENERGIC RECEPTOR BLOCKING; BRADYCARDIA; CLINICAL TRIAL; CONSTIPATION; CONTROLLED DRUG RELEASE; CORONARY ARTERY ATHEROSCLEROSIS; DEFIBRILLATOR; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG CONTRAINDICATION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; EDEMA; EXERCISE TOLERANCE; FATIGUE; HEART ATRIUM FIBRILLATION; HEART DEATH; HEART DISEASE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART MOVEMENT; HEART MUSCLE ISCHEMIA; HEART SURGERY; HEART TRANSPLANTATION; HEART VENTRICLE TACHYCARDIA; HIGH RISK PATIENT; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY; HYPOTENSION; LOADING DRUG DOSE; LONG TERM CARE; LUNG CONGESTION; LUNG EDEMA; MORTALITY; PATHOPHYSIOLOGY; PROGNOSIS; PROSTATISM; REVIEW; RISK ASSESSMENT; SIDE EFFECT; SUDDEN DEATH; SURVIVAL; SUSTAINED DRUG RELEASE; TREATMENT PLANNING; UNSPECIFIED SIDE EFFECT; WATCHFUL WAITING; XEROSTOMIA;

ADRENERGIC BETA-ANTAGONISTS; CARDIOMYOPATHY, HYPERTROPHIC; DECISION TREES; DEFIBRILLATORS, IMPLANTABLE; DISOPYRAMIDE; HUMANS; VERAPAMIL;

EID: 33846229996     PISSN: 13028723     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (67)

1. Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation 1995;92:785-9.
2. Zou Y, Song L, Wang Z, Ma A, Liu T, Gu H, et al. Prevalence of idiopathic hypertrophic cardiomyopathy in China: a population based echocardiographic analysis of 8080 adults. Am J Med 2004;116:14-8.
3. Sherrid M BI. Pharmacologic treatment of symptomatic hypertrophic cardiomyopathy. In: Maron B, editor. Diagnosis and Management of Hypertrophic Cardiomyopathy. London: Blackwell-Futura, 2004. p. 200-19.
4. Lele SS, Thomson HL, Seo H, Belenkie I, McKenna WJ, Frenneaux MP. Exercise capacity in hypertrophic cardiomyopathy. Role of stroke volume limitation, heart rate, and diastolic filling characteristics. Circulation 1995;92:2886-94.
5. Shirani J, Pick R, Roberts WC, Maron BJ. Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death. J Am Coll Cardiol 2000;35:36-44.
6. Cannon RO, 3rd, Rosing DR, Maron BJ, Leon MB, Bonow RO, Watson RM, et al. Myocardial ischemia in patients with hypertrophic cardiomyopathy: contribution of inadequate vasodilator reserve and elevated left ventricular filling pressures. Circulation 1985;71:234-43.
7. Maron BJ, Wolfson JK, Epstein SE, Roberts WC. Intramural ("small vessel") coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 1986;8:545-57.
8. Spirito P, Seidman CE, McKenna WJ, Maron BJ. The management of hypertrophic cardiomyopathy. N Engl J Med 1997;336:775-85.
9. Maron BJ. Hypertrophic cardiomyopathy: a systematic review. JAMA 2002;287:1308-20.
10. Marwick TH, Nakatani S, Haluska B, Thomas JD, Lever HM. Provocation of latent left ventricular outflow tract gradients with amyl nitrite and exercise in hypertrophic cardiomyopathy. Am J Cardiol 1995;75:805-9.
11. Schwammenthal E, Schwartzkopff B, Block M, Johns J, Losse B, Engberding R, et al. Doppler echocardiographic assessment of the pressure gradient during bicycle ergometry in hypertrophic cardiomyopathy. Am J Cardiol 1992;69:1623-8.
12. Romeo F, Pelliccia F, Cristofani R, Martuscelli F, Reale A. Hypertrophic cardiomyopathy: is a left ventricular outflow tract gradient a major prognostic determinant? Eur Heart J 1990;11:233-40.
13. Cecchi F, Olivotto I, Montereggi A, Santoro G, Dolara A, Maron BJ. Hypertrophic cardiomyopathy in Tuscany: clinical course and outcome in an unselected regional population. J Am Coll Cardiol 1995;26:1529-36.
14. Maron BJ, Casey SA, Poliac LC, Gohman TE, Almquist AK, Aeppli DM. Clinical course of hypertrophic cardiomyopathy in a regional United States cohort. Jama 1999;281:650-5.
15. Kaltenbach M, Hopf R, Kober G, Bussmann WD, Keller M, Petersen Y. Treatment of hypertrophic obstructive cardiomyopathy with verapamil. Br Heart J 1979;42:35-42.
16. Rosing DR, Condit JR, Maron BJ, Kent KM, Leon MB, Bonow RO, et al. Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy: III. Effects of long-term administration. Am J Cardiol 1981;48:545-53.
17. Rosing DR, Idanpaan-Heikkila U, Maron BJ, Bonow RO, Epstein SE. Use of calcium-channel blocking drugs in hypertrophic cardiomyopathy. Am J Cardiol 1985;55:185B-95B.
18. Gregor P, Widimsky P, Cervenka V, Visek V, Sladkova T, Dvorak J. Use of verapamil in the treatment of hypertrophic cardiomyopathy. Cor Vasa 1986;28:404-12.
19. Udelson JE, Bonow RO, O'Gara PT, Maron BJ, Van Lingen A, Bacharach SL, et al. Verapamil prevents silent myocardial perfusion abnormalities during exercise in asymptomatic patients with hypertrophic cardiomyopathy. Circulation 1989;79:1052-60.
20. Bonow RO, Dilsizian V, Rosing DR, Maron BJ, Bacharach SL, Green MV. Verapamil-induced improvement in left ventricular diastolic filling and increased exercise tolerance in patients with hypertrophic cardiomyopathy: short- and long-term effects. Circulation 1985;72:853-64.
21. Hopf R, Kaltenbach M. 10-year results and survival of patients with hypertrophic cardiomyopathy treated with calcium antagonists. Z Kardiol 1987;76 Suppl 3:137-44.
22. Bonow RO, Rosing DR, Epstein SE. The acute and chronic effects of verapamil on left ventricular function in patients with hypertrophic cardiomyopathy. Eur Heart J 1983;4 Suppl F:57-65.
23. Bonow RO, Rosing DR, Bacharach SL, Green MV, Kent KM, Lipson LC, et al. Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy. Circulation 1981;64:787-96.
24. Curtius JM, Stoecker J, Loesse B, Welslau R, Scholz D. Changes of the degree of hypertrophy in hypertrophic obstructive cardiomyopathy under medical and surgical treatment. Cardiology 1989;76:255-63.
25. Kunkel B, Schneider M, Eisenmenger A, Bergmann B, Hopf R, Kaltenbach M. Myocardial biopsy in patients with hypertrophic cardiomyopathy: correlations between morphologic and clinical parameters and development of myocardial hypertrophy under medical therapy. Z Kardiol 1987;76 Suppl 3:33-8.
26. Hopf R, Thomas J, Klepzig H, Kaltenbach M. Treatment of hypertrophic cardiomyopathy with nifedipine and propranolol in combination. Z Kardiol 1987;76:469-78.
27. Betocchi S, Piscione F, Losi MA, Pace L, Boccalatte M, Perrone-Filardi P, et al. Effects of diltiazem on left ventricular systolic and diastolic function in hypertrophic cardiomyopathy. Am J Cardiol 1996;78:451-7.
28. Kass DA, Wolff MR, Ting CT, Liu CP, Chang MS, Lawrence W, et al. Diastolic compliance of hypertrophied ventricle is not acutely altered by pharmacologic agents influencing active processes. Ann Intern Med 1993;119:466-73.
29. Hess OM, Grimm J, Krayenbuehl HP. Diastolic function in hypertrophic cardiomyopathy: effects of propranolol and verapamil on diastolic stiffness. Eur Heart J 1983;4 Suppl F:47-56.
30. Bonow RO, Ostrow HG, Rosing DR, Cannon RO, 3d, Lipson LC, Maron BJ, et al. Effects of verapamil on left ventricular systolic and diastolic function in patients with hypertrophic cardiomyopathy: pressure-volume analysis with a nonimaging scintillation probe. Circulation 1983;68:1062-73.
31. Nishimura RA HO, Tajik AJ. Failure of calcium channel blockers to improve ventricular relaxation in humans. J Am Coll Cardiol 1993;21:182-8.
32. Hirota Y, Shimizu G, Kaku K, Furubayashi K, Kawamura K, Takatsu I. Pathophysiology of hypertrophic and congestive cardiomyopathies: a guide of fundamental therapeutic approach (author's transl). J Cardiogr 1981;11:1127-46.
33. Matsubara H, Nakatani S, Nagata S, Ishikura F, Katagiri Y, Ohe T, et al. Salutary effect of disopyramide on left ventricular diastolic function in hypertrophic obstructive cardiomyopathy. J Am Coll Cardiol 1995;26:768-75.
34. Pollick C, Kimball B, Henderson M, Wigle ED. Disopyramide in hypertrophic cardiomyopathy. I. Hemodynamic assessment after intravenous administration. Am J Cardiol 1988;62:1248-51.
35. Wigle ED, Sasson Z, Henderson MA, Ruddy TD, Fulop J, Rakowski H, et al. Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis 1985;28:1-83.
36. Maron MS, Olivotto I, Betocchi S, Casey SA, Lesser JR, Losi MA, et al. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy. N Engl J Med 2003;348:295-303.
37. Schoendube FA, Klues HG, Reith S, Flachskampf FA, Hanrath P, Messmer BJ. Long-term clinical and echocardiographic follow-up after surgical correction of hypertrophic obstructive cardiomyopathy with extended myectomy and reconstruction of the subvalvular mitral apparatus. Circulation 1995;92:II122-7.
38. Sherrid MV, Gunsburg DZ, Moldenhauer S, Pearie G. Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 2000;36:1344-54.
39. Jiang L, Levine RA, King ME, Weyman AE. An integrated mechanism for systolic anterior motion of the mitral valve in hypertrophic cardiomyopathy based on echocardiographic observations. Am Heart J 1987;113:633-44.
40. Messmer BJ. Extended myectomy for hypertrophic obstructive cardiomyopathy. Ann Thorac Surg 1994;58:575-7.
41. Schoendube FA, Klues HG, Reith S, Messmer BJ. Surgical correction of hypertrophic obstructive cardiomyopathy with combined myectomy, mobilisation and partial excision of the papillary muscles. Eur J Cardiothorac Surg 1994;8:603-8.
42. Binder J SR, Gersh BJ, Van Driest SL, Tajik AJ, Nishimura RA, Ackerman MJ. Echocardiography-guided genetic testing in hypertrophic cardiomyopathy: septal morphological features predict the presence of myofilament mutations. Mayo Clinic Proceedings 2006;81:459-67.
43. Sherrid MV, Chu CK, Delia E, Mogtader A, Dwyer EM, Jr. An echocardiographic study of the fluid mechanics of obstruction in hypertrophic cardiomyopathy. J Am Coll Cardiol 1993;22:816-25.
44. Sherrid MV, Pearle G, Gunsburg DZ. Mechanism of benefit of negative inotropes in obstructive hypertrophic cardiomyopathy. Circulation 1998;97:41-7.
45. Sherrid MV, Gunsburg DZ, Pearle G. Mid-systolic drop in left ventricular election velocity in obstructive hypertrophic cardiomyopathy - the lobster claw abnormality. J Am Soc Echocardiogr 1997;10:707-12.
46. Wigle ED, Rakowski H, Kimball BP, Williams WG. Hypertrophic cardiomyopathy. Clinical spectrum and treatment. Circulation 1995;92:1680-92.
47. Sherrid MV, Barac I, McKenna WJ, Elliott PM, Dickie S, Chojnowska L, et al. Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 2005;45:1251-8.
48. Cherian G, Brockington IM, Shah P, Oakley CM, Goodwin JF. Beta-adrenergic blockade in patients with hypertrophic obstructive cardiomyopathy. Am Heart J 1967;73:140-1.
49. Harrison DC BE, Glick G, Manson DT, Chidsey CA, Ross J Jr. Effects of beta adrenergic blockade on the circulation with particular reference to observations in patients with hypertrophic subaortic stenosis. Circulation 1964;29:84-98.
50. Sharma S, Elliott F, Whyte G, Jones S, Mahon N, Whipp B, et al. Utility of cardiopulmonary exercise in the assessment of clinical determinants of functional capacity in hypertrophic cardiomyopathy. Am J Cardiol 2000;86:162-8.
51. Wigle ED. Hypertrophic cardiomyopathy: a 1987 viewpoint. Circulation 1987;75:311-22.
52. McKenna WJ, Behr ER. Hypertrophic cardiomyopathy: management, risk stratification, and prevention of sudden death. Heart 2002;87:169-76.
53. Rosing DR, Kent KM, Borer JS, Seides SF, Maron BJ, Epstein SE. Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. I. Hemodynamic effects. Circulation 1979;60:1201-7.
54. Hanrath P, Schluter M, Sonntag F, Diemert J, Bleifeld W. Influence of verapamil therapy on left ventricular performance at rest and during exercise in hypertrophic cardiomyopathy. Am J Cardiol 1983;52:544-8.
55. Rosing DR, Kent KM, Maron BJ, Epstein SE. Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. II. Effects on exercise capacity and symptomatic status. Circulation 1979;60:1208-13.
56. Tendera M, Polonski L, Kozielska E. Left ventricular end-diastolic pressure-volume relationships in hypertrophic cardiomyopathy. Changes induced by verapamil. Chest 1983;84:54-7.
57. Epstein SE, Rosing DR. Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy. Circulation 1981;64:437-41.
58. Lorell BH. Use of calcium channel blockers in hypertrophic cardiomyopathy. Am J Med 1985;78:43-54.
59. Pollick C GK, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, and Popp RL. The cardiac effects of d- and I-disopyramide in normal subjects: a noninvasive study. Circulation 1982;66:447-53.
60. Pollick C. Muscular subaortic stenosis: hemodynamic and clinical Improvement after disopyramide. N Engl J Med 1982;307:997-9.
61. Sherrid M, Delia E, Dwyer E. Oral disopyramide therapy for obstructive hypertrophic cardiomyopathy. Am J Cardiol 1988;62:1085-8.
62. Pollick C. Disopyramide in hypertrophic cardiomyopathy. II. Noninvasive assessment after oral administration. Am J Cardiol 1988;62:1252-5.
63. Kimball BP, Bui S, Wigle ED. Acute dose-response effects of intravenous disopyramide in hypertrophic obstructive cardiomyopathy. Am Heart J 1993;125:1691-7.
64. Cokkinos DV, Salpeas D, Ioannou NE, Christoulas S. Combination of disopyramide and propranolol in hypertrophic cardiomyopathy. Can J Cardiol 1989;5:33-6.
65. Hongo M, Nakatsuka T, Takenaka H, Tanaka M, Watanabe N, Yazaki Y, et al. Effects of intravenous disopyramide on coronary hemodynamics and vasodilator reserve in hypertrophic obstructive cardiomyopathy. Cardiology 1996;87:6-11.
66. Duncan WJ, Tyrrell MJ, Bharadwaj BB. Disopyramide as a negative inotrope in obstructive cardiomyopathy in children. Can J Cardiol 1991;7:81-6.
67. Niki K, Sugawara M, Asano R, Oka T, Kondoh Y, Tanino S, et al. Disopyramide improves the balance between myocardial oxygen supply and demand in patients with hypertrophic obstructive cardiomyopathy. Heart Vessels 1997;12:111-8.