Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production

American Journal of Physiology - Renal Physiology

Volumn 292, Issue 1, 2007, Pages

  Lock, Helen R ^a   Sacks, Steven H ^a   Robson, Michael G ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

Collagen; Glomerulus; Kidney

Indexed keywords

COLLAGEN TYPE 4; RAPAMYCIN; S6 KINASE; THYMIDINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL PROLIFERATION; COLLAGEN SYNTHESIS; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; EXTRACELLULAR MATRIX; GENE EXPRESSION; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 33846222881     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00128.2006     Document Type: Article

References (17)

1. Abe K, Li K, Sacks SH, Sheerin NS. The membrane attack complex, C5b-9, upregulates collagen gene expression in renal tubular epithelial cells. Clin Exp Immunol 136: 60-66, 2004.
2. Cao W, Mohacsi P, Shorthouse R, Pratt R, Morris RE. Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506. Transplantation 59: 390-395, 1995.
3. Daniel C, Renders L, Amann K, Schulze-Lohoff E, Hauser IA, Hugo C. Mechanisms of everolimus-induced glomerulosclerosis after glomerular injury in the rat. Am J Transplant 5: 2849-2861, 2005.
4. Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev 15: 807-826, 2001.
5. Huang S, Bjornsti MA, Houghton PJ. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2: 222-232, 2003.
6. Kim MS, Park J, Ha H, Kim YS, Kang SW, Jeong HJ, Kang DH, Yang CW. Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells. Yonsei Med J 45: 1121-1126, 2004.
7. Lehman JA, Calvo V, Gomez-Cambronero J. Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase. J Biol Chem 278: 28130-28138, 2003.
8. Lieberthal W, Fuhro R, Andry CC, Rennke H, Abernathy VE, Koh JS, Valeri R, Levine JS. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 281: F693-F706, 2001.
9. Martin KA, Rzucidlo EM, Merenick BL, Fingar DC, Brown DJ, Wagner RJ, Powell RJ. The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. Am J Physiol Cell Physiol 286: C507-C517, 2004.
10. Marx SO, Jayaraman T, Go LO, Marks AR. Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circ Res 76: 412-417, 1995.
11. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45, 2001.
12. Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. J Immunol 166: 3201-3209, 2001.
13. Sundarraj N, Willson J. Monoclonal antibody to human basement membrane collagen type IV. Immunology 47: 133-140, 1982.
14. Takemoto M, Asker N, Gerhardt H, Lundkvist A, Johansson BR, Saito Y, Betsholtz C. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol 161: 799-805, 2002.
15. Wang W, Chan YH, Lee W, Chan L. Effect of rapamycin and FK506 on mesangial cell proliferation. Transplant Proc 33: 1036 -1037, 2001.
16. Watson CJ. Sirolimus (rapamycin) in clinical transplantation. Transp Rev 15: 165-177, 2001.
17. Zhu J, Wu J, Frizell E, Liu SL, Bashey R, Rubin R, Norton P, Zern MA. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 117: 1198-1204, 1999.