Elevated pressure selectively blunts flow-evoked vasodilatation in rat mesenteric small arteries

British Journal of Pharmacology

Volumn 150, Issue 1, 2007, Pages 80-87

  Christensen, F H ^a   Hansen, T ^a   Stankevicius, E ^a,b   Buus, N H ^a   Simonsen, U ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

Author keywords

Endothelial dysfunction; Flow induced vasodilatation; Nitric oxide; Superoxide; Tempol

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; ACETYLCHOLINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; ENRASENTAN; GUANYLATE CYCLASE ACTIVATOR; INDOMETACIN; N ACETYL S NITROSOPENICILLAMINE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTERY CONSTRICTION; ARTERY DIAMETER; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DONOR; DRUG EFFECT; EVOKED RESPONSE; HYPERTENSION; MALE; MESENTERIC ARTERY; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SHEAR STRESS;

ACETYLCHOLINE; ANIMALS; MALE; MESENTERIC ARTERIES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENICILLAMINE; PYRAZOLES; PYRIDINES; RATS; RATS, WISTAR; SUPEROXIDES; VASODILATION;

EID: 33846220722     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706965     Document Type: Article

References (43)

1. Adeagbo AS, Joshua IG, Falkner C, Matheson PJ (2003). Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension. Eur J Pharmacol 481: 91-100.
2. Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM et al. (2004). Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 110: 2233-2240.
3. Bauersachs J, Bouloumie A, Mulsch A, Wiemer G, Fleming I, Busse R (1998). Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production. Cardiovasc Res 37: 772-779.
4. Bussemaker E, Popp R, Fisslthaler B, Larson CM, Fleming I, Busse R et al. (2003). Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery. Hypertension 42: 562-568.
5. Buus NH, Simonsen U, Pilegaard HK, Mulvany MJ (2000). Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries. Br J Pharmacol 129: 184-192.
6. Crane GJ, Garland CJ (2004). Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery. Br J Pharmacol 142: 43-50.
7. Debruyn VH, Nuno DW, Cappellibigazzi M, Dole WP, Lamping KG (1994). Effect of acute hypertension in the coronary circulation - role of mechanical factors and oxygen radicals. J Hypertens 12: 163-172.
8. Dobrian AD, Schriver SD, Prewitt RL (2001). Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. Hypertension 38: 361-366.
9. + in the rat isolated mesenteric artery. Am J Physiol Heart Circ Physiol 280: H2424-H2429.
10. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 396: 269-272.
11. B receptor deficient rats. Hypertension 42: 401.
12. Fujii K, Tominaga M, Ohmori S, Kobayashi K, Koga T, Takata Y et al. (1992). Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth-muscle of the mesenteric-artery of spontaneously hypertensive rats. Circ Res 70: 660-669.
13. Fukui T, Ishizaka N, Rajagopalan S, Laursen JB, Capers Q, Taylor WR et al. (1997). p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res 80: 45-51.
14. Gryglewski RJ, Palmer RMJ, Moncada S (1986). Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320: 454-456.
15. Hamilton CA, Brosnan MJ, Al Benna S, Berg G, Dominiczak AF (2002). NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension 40: 755-762.
16. Harder DR, Sanchezferrer C, Kauser K, Stekiel WJ, Rubanyi GM (1989). Pressure releases a transferable endothelial contractile factor in cat cerebral-arteries. Circ Res 65: 193-198.
17. Hasdai D, Holmes DR, Garratt KN, Edwards WD, Lerman A (1997). Mechanical pressure and stretch release endothelin-1 from human atherosclerotic coronary arteries in vivo. Circulation 95: 357-362.
18. Heitzer T, Wenzel U, Hink U, Krollner D, Skatchkov M, Stahl RAK et al. (1999). Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: evidence for an involvement of protein kinase C. Kidney Int 55: 252-260.
19. Hishikawa K, Oemar BS, Yang Z, Luscher TF (1997). Pulsatile stretch stimulates superoxide production and activates nuclear factor-kappa B in human coronary smooth muscle. Circ Res 81: 797-803.
20. Hoshino J, Nakamura T, Kurashina T, Saito Y, Sumino H, Ono Z et al. (1998). Antagonism of ANG II type 1 receptors protects the endothelium during the early stages of renal hypertension in rats. Am J Physiol 275: R1950-R1957.
21. Huang A, Sun D, Kaley G, Koller A (1998). Superoxide released to high intra-arteriolar pressure reduces nitric oxide-mediated shear stress- and agonist-induced dilations. Circ Res 83: 960-965.
22. Kloss S, Bouloumie A, Mulsch A (2000). Aging and chronic hypertension decrease expression of rat aortic soluble guanylyl cyclase. Hypertension 35: 43-47.
23. Koller A, Huang A (1994). Impaired nitric oxide-mediated flow-induced dilation in arterioles of spontaneously hypertensive rats. Circ Res 74: 416-421.
24. Lauth M, Berger MM, Cattaruzza M, Hecker M (2000). Elevated perfusion pressure upregulates endothelin-1 and endothelin B receptor expression in the rabbit carotid artery. Hypertension 35: 648-654.
25. L, Fink GD, Watts SW, Northcott CA, Galligan JJ, Pagano PJ et al. (2003). Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension. Circulation 107: 1053-1058.
26. 2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery. Br J Pharmacol 147: 506-515.
27. Mather S, Dora KA, Sandow SL, Winter P, Garland CJ (2005). Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries. Circ Res 97: 399-407.
28. Paniagua OA, Bryant MB, Panza JA (2000). Transient hypertension directly impairs endothelium-dependent vasodilation of the human microvasculature. Hypertension 36: 941-944.
29. Panza JA, Quyyumi AA, Brush JE, Epstein SE (1990). Abnormal endothelium-dependent vascular relaxation in patients with essential- hypertension. N Engl J Med 323: 22-27.
30. Plane F, Garland CJ (1996). Influence of contractile agonists on the mechanism of endothelium-dependent relaxation in rat isolated mesenteric artery. Br J Pharmacol 119: 191-193.
31. Preik M, Kelm M, Feelisch M, Strauer BE (1996). Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension. J Hypertens 14: 903-908.
32. Rizzoni D, Porteri E, Castellano M, Bettoni G, Muiesan ML, Muiesan P et al. (1996). Vascular hypertrophy and remodeling in secondary hypertension. Hypertension 28: 785-790.
33. Rubanyi GM (1988). Endothelium-dependent pressure-induced contraction of isolated canine carotid arteries. Am J Physiol 255: H783-H788.
34. Schnackenberg CG, Welch WJ, Wilcox CS (1998). Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension 32: 59-64.
35. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A (1998). Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97: 2222-2229.
36. Thorsgaard M, Lopez V, Buus NH, Simonsen U (2003). Different modulation by Ca(2+)-activated K(+) channel blockers and herbimycin of acetylcholine- and flow-evoked vasodilatation in rat mesenteric small arteries. Br J Pharmacol 138: 1562-1570.
37. Tomioka H, Hattori Y, Fukao M, Sato A, Liu MY, Sakuma I et al. (1999). Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: importance of processes mediating precontractions. J Vasc Res 36: 311-320.
38. Ulker S, McKeown PP, Bayraktutan U (2003). Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 41: 534-539.
39. Ungvari Z, Csiszar A, Huang A, Kaminski PM, Wolin MS, Koller A (2003). High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase. Circulation 108: 1253-1258.
40. Ungvari Z, Csiszar A, Kaminski PM, Wolin MS, Koller A (2004). Chronic high pressure-induced arterial oxidative stress - involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system. Am J Pathol 165: 219-226.
41. Vanhoutte PM, Feletou M, Taddei S (2005). Endothelium-dependent contractions in hypertension. Br J Pharmacol 144: 449-458.
42. Wei EP, Kontos HA, Christman CW, Dewitt DS, Povlishock JT (1985). Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension. Circ Res 57: 781-787.
43. Zalba G, Beaumont FJ, San Jose G, Fortuno A, Fortuno MA, Etayo JC et al. (2000). Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 35: 1055-1061.