메뉴 건너뛰기




Volumn 45, Issue 1, 2007, Pages 45-49

Isolation and identification of a major impurity in a new bulk drug candidate by preparative LC, ESI-MSn, LC-MS-MS, and NMR

Author keywords

[No Author keywords available]

Indexed keywords


EID: 33846214776     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/45.1.45     Document Type: Article
Times cited : (4)

References (15)
  • 1
    • 85039142166 scopus 로고    scopus 로고
    • International Conference on the Harmonization of the Technical Requirement for Registration of Pharmaceuticals for Human Use (ICH, Q3AR, Impurities in New Drug Substances, Revised guideline. ICH, Geneva, Switzerland, 2002
    • International Conference on the Harmonization of the Technical Requirement for Registration of Pharmaceuticals for Human Use (ICH). Q3A(R): Impurities in New Drug Substances, Revised guideline. ICH, Geneva, Switzerland, 2002.
  • 2
    • 1542787788 scopus 로고    scopus 로고
    • Chemical and analytical characterization of related organic impurity in drugs
    • S. Gorog. Chemical and analytical characterization of related organic impurity in drugs. Anal. Bioanal. Chem. 377: 852-62 (2003).
    • (2003) Anal. Bioanal. Chem , vol.377 , pp. 852-862
    • Gorog, S.1
  • 3
    • 0347284341 scopus 로고    scopus 로고
    • Complementary use of gas chromatography-mass spectrometry, gas chromatography-atomic emission detection and nuclear magnetic resonance for identification of pharmaceutically related impurities of unknown structures
    • K. Laniewski, M. Vagero, E. Forsberg, T. Forngren, and G. Hagman. Complementary use of gas chromatography-mass spectrometry, gas chromatography-atomic emission detection and nuclear magnetic resonance for identification of pharmaceutically related impurities of unknown structures. J. Chromatogr. A. 1027: 93-102 (2004).
    • (2004) J. Chromatogr. A , vol.1027 , pp. 93-102
    • Laniewski, K.1    Vagero, M.2    Forsberg, E.3    Forngren, T.4    Hagman, G.5
  • 4
    • 0033832634 scopus 로고    scopus 로고
    • Application of hyphenated LC-MS techniques in pharmaceutical analysis
    • J. Ermer and M. Vogel. Application of hyphenated LC-MS techniques in pharmaceutical analysis. Biomed. Chromatogr. 14: 373-83 (2000).
    • (2000) Biomed. Chromatogr , vol.14 , pp. 373-383
    • Ermer, J.1    Vogel, M.2
  • 5
    • 0033824375 scopus 로고    scopus 로고
    • The use of liquid chromatography-mass spectrometry for the identification of drug degradation products in pharmaceutical formulations
    • Y. Wu. The use of liquid chromatography-mass spectrometry for the identification of drug degradation products in pharmaceutical formulations. Biomed. Chromatogr. 14: 384-96 (2000).
    • (2000) Biomed. Chromatogr , vol.14 , pp. 384-396
    • Wu, Y.1
  • 7
    • 0028069177 scopus 로고
    • Use of liquid chromatography-nuclear magnetic resonance spectroscopy for the identification of impurities in drug substances
    • J.K. Roberts and R.J. Smith. Use of liquid chromatography-nuclear magnetic resonance spectroscopy for the identification of impurities in drug substances. J. Chromatogr. A 677: 385-89 (1994).
    • (1994) J. Chromatogr. A , vol.677 , pp. 385-389
    • Roberts, J.K.1    Smith, R.J.2
  • 8
    • 0033835592 scopus 로고    scopus 로고
    • Hyphenated HPLC-NMR and its application in drug discovery
    • S.X. Peng. Hyphenated HPLC-NMR and its application in drug discovery. Biomed. Chromatogr. 14: 430-41 (2000).
    • (2000) Biomed. Chromatogr , vol.14 , pp. 430-441
    • Peng, S.X.1
  • 9
  • 10
    • 0028331875 scopus 로고
    • Preparative liquid chromatographic isolation of unknown impurities in Arbidol and SI-5
    • L. Miller and R. Bergeron. Preparative liquid chromatographic isolation of unknown impurities in Arbidol and SI-5. J. Chromatogr. A 658: 489-96 (1994).
    • (1994) J. Chromatogr. A , vol.658 , pp. 489-496
    • Miller, L.1    Bergeron, R.2
  • 11
    • 0032970069 scopus 로고    scopus 로고
    • Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric pressure chemical ionization liquid chromatography/mass spectrometry and nuclear magnetic resonance spectrometry
    • G.J. Lehr, T.L. Barry, G.M. Hanna, and S.W. Zito. Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric pressure chemical ionization liquid chromatography/mass spectrometry and nuclear magnetic resonance spectrometry. J. Pharm. Biomed. Anal. 19: 373-89 (1999).
    • (1999) J. Pharm. Biomed. Anal , vol.19 , pp. 373-389
    • Lehr, G.J.1    Barry, T.L.2    Hanna, G.M.3    Zito, S.W.4
  • 12
    • 0242541169 scopus 로고    scopus 로고
    • LC determination of impurities in methoxsalen drug substance: Isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR
    • G.J. Lehr and T.L. Barry. LC determination of impurities in methoxsalen drug substance: isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR. J. Pharm. Biomed. Anal. 33: 627-37 (2003).
    • (2003) J. Pharm. Biomed. Anal , vol.33 , pp. 627-637
    • Lehr, G.J.1    Barry, T.L.2
  • 13
    • 4344586300 scopus 로고    scopus 로고
    • Identification and characterization of potential impurities of donepezil
    • K.V. Krishna Reddy and J.M. Babu. Identification and characterization of potential impurities of donepezil. J. Pharm. Biomed. Anal. 35: 1047-58 (2004).
    • (2004) J. Pharm. Biomed. Anal , vol.35 , pp. 1047-1058
    • Krishna Reddy, K.V.1    Babu, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.