Noncholinergic lesions of the medial septum impair sequential learning of different spatial locations

Journal of Neuroscience

Volumn 27, Issue 2, 2007, Pages 299-303

  Dwyer, Trisha A ^a   Servatius, Richard J ^b,c   Pang, Kevin C H ^a,b,d  

^a BOWLING GREEN STATE UNIVERSITY   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; GABA; Hippocampus; Learning; Memory; Theta rhythm

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; KAINIC ACID; SAPORIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIORAL SCIENCE; CHOLINERGIC NERVE CELL; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DIAGONAL BAND OF BROCA; HIPPOCAMPUS THETA RHYTHM; LEARNING; MALE; MAZE TEST; MEMORY; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD; SEPTUM PELLUCIDUM; SPATIAL DISCRIMINATION; TASK PERFORMANCE;

ANIMALS; CHOLINERGIC FIBERS; MALE; MAZE LEARNING; PSYCHOMOTOR PERFORMANCE; RATS; RATS, LONG-EVANS; SEPTUM OF BRAIN; SPATIAL BEHAVIOR;

EID: 33846211361     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4189-06.2007     Document Type: Article

References (29)

1. Amaral DG, Kurz J (1985) An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal-formation of the rat. J Comp Neurol 240:37-59.
2. Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-416.
3. Bassant MH, Jouvenceau A, Apartis E, Poindessous-Jazat F, Dutar P, Billard JM (1998) Immunolesion of the cholinergic basal forebrain: effects on functional properties of hippocampal and septal neurons. Int J Dev Neurosci 16:613-632.
4. Baxter MG, Bucci DJ, Gorman LK, Wiley RG, Gallagher M (1995) Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats. Behav Neurosci 109:714-722.
5. Berger-Sweeney J, Heckers S, Mesulam MM, Wiley RG, Lappi DA, Sharma M (1994) Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. J Neurosci 14:4507-4519.
6. Cahill JF, Baxter MG (2001) Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning. Eur J Neurosci 14:1856-1864.
7. Chang Q, Gold PE (2004) Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG-saporin. Hippocampus 14:170-179.
8. Coyle JT, Price DL, DeLong MR (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219:1184-1190.
9. Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL (1996) Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin. Behav Brain Res 82:93-101.
10. Freund TF (1989) GABAergic septohippocampal neurons contain parvalbumin. Brain Res 478:375-381.
11. Geisser S, Greenhouse SW (1958) An extension of Box's results on the use of the F distribution in multivariate analysis. Ann Math Stat 29:885-891.
12. Hasselmo ME (2005) What is the function of hippocampal theta rhythm? Linking behavioral data to phasic properties of field potential and unit recording data. Hippocampus 15:936-949.
13. Hasselmo ME, Wyble BP, Wallenstein GV (1996) Encoding and retrieval of episodic memories: Role of cholinergic and GABAergic modulation in the hippocampus. Hippocampus 6:693-708.
14. Jakab R, Leranth C (1995) Septum. In: The rat nervous system, Ed 2 (Paxinos G, ed), pp 405-442. San Diego: Academic.
15. Kesner RP, Crutcher KA, Measom MO (1986) Medial septal and nucleus basalis magnocellularis lesions produce order memory deficit in rats which mimic symptomology of Alzheimer's disease. Neurobiol Aging 7:287-295.
16. Kiss J, Magloczky Z, Somogyi J, Freund TF (1997) Distribution of calretinin-containing neurons relative to other neurochemically identified cell types in the medial septum of the rat. Neuroscience 78:399-410.
17. Lee MG, Chrobak JJ, Sik A, Wiley RG, Buzsaki G (1994) Hippocampal theta activity following selective lesion of the septal cholinergic system. Neuroscience 62:1033-1047.
18. Malthe-Sorenssen D, Odden E, Walaas I (1980) Selective destruction by kainic acid of neurons innervated by putative glutamatergic afferents in septum and nucleus of the diagonal band. Brain Res 182:461-465.
19. Pang KC, Nocera R (1999) Interactions between 192-IgG and intraseptal cholinergic and GABAergic drugs: role of cholinergic medial septal neurons in spatial working memory. Behav Neurosci 113:265-275.
20. Pang KC, Nocera R, Secor AJ, Yoder RM (2001) GABAergic septohippocampal neurons are not necessary for spatial memory. Hippocampus 11:814-827.
21. Pascale Simon A, Poindessous-Jasat F, Dutar P, Epelbaum J, Bassant M (2006) Firing properties of anatomically identified neurons in the medial septum of anesthetized and unanesthetized restrained rats. J Neurosci 26:9038-9046.
22. Shen J, Barnes CA, Wenk GL, McNaughton BL (1996) Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory. Behav Neurosci 110:1181-1186.
23. Smith HR, Pang KC (2005) Orexin-saporin lesions of the medial septum impair spatial memory. Neuroscience 132:261-271.
24. Stewart M, Fox SE (1990) Do septal neurons pace the hippocampal theta rhythm? Trends Neurosci 13:163-168.
25. Walsh TJ, Herzog CD, Gandhi C, Stackman RW, Wiley RG (1996) Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits. Brain Res 726:69-79.
26. West M (1999) Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci 22:51-61.
27. Whishaw IQ (1985) Formation of a place learning-set by the rat: a new paradigm for neuro-behavioral studies. Physiol Behav 35:139-143.
28. Winson J (1978) Loss of hippocampal theta rhythm results in spatial memory deficit in the rat. Science 201:160-163.
29. Yoder RM, Pang KC (2005) Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm. Hippocampus 15:381-392.