Diagnostics for confounding in PK/PD models for oxcarbazepine

Statistics in Medicine

Volumn 26, Issue 2, 2007, Pages 290-308

  Nedelman, Jerry R ^a   Rubin, Donald B ^b   Sheiner, Lewis B ^c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Instrumental variables; Pediatric bridging; Pharmacodynamics; Pharmacokinetics; Potential outcomes; Rubin's causal model; Sensitivity analysis; Two stage least squares

Indexed keywords

OXCARBAZEPINE; PLACEBO; SODIUM CHANNEL;

ANTICONVULSANT ACTIVITY; ARTICLE; CHANNEL GATING; CLINICAL TRIAL; CONFOUNDING VARIABLE; CONTROLLED CLINICAL TRIAL; DRUG APPROVAL; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; EPILEPSY; HUMAN; MONOTHERAPY; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; TIME; TREATMENT OUTCOME; UNIVARIATE ANALYSIS;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, BIOLOGICAL; RANDOMIZED CONTROLLED TRIALS; SEIZURES;

EID: 33846199528     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.2542     Document Type: Article

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