Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria

Molecular Immunology

Volumn 44, Issue 9, 2007, Pages 2235-2248

  Dobano C ^a,b   McTague, A ^a   Sette, A ^c   Hoffman, S L ^a   Rogers, W O ^a   Doolan, D L ^a,d  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c Epimmune   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Circumsporozoite protein; Immune deviation; Malaria; MHC binding; Protective immunity; T cells

Indexed keywords

AMINO ACID; CIRCUMSPOROZOITE PROTEIN; DNA VACCINE; EPITOPE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN; PLASMID DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA IMMUNIZATION; FEMALE; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALARIA; MOUSE; NONHUMAN; PLASMODIUM YOELII; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; ANIMALS; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGENS, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DNA, PROTOZOAN; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNITY; IMMUNODOMINANT EPITOPES; INTERFERON TYPE II; MALARIA; MICE; MUTAGENESIS; MUTANT PROTEINS; MUTATION; PEPTIDES; PLASMIDS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR NECROSIS FACTOR-ALPHA;

PLASMODIUM YOELII;

EID: 33846184733     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.11.003     Document Type: Article

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