Transfection and anti-HBV effect mediated by the hepatocytes-targeting cationic liposomes co-modified with β-sitosterol-β-D-glucoside and Brij 35

Yaoxue Xuebao

Volumn 41, Issue 11, 2006, Pages 1111-1115

  Zhang, Yuan ^a   Qi, Xian Rong ^a   Gao, Yan ^b   Wei, Lai ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Co modification; Endocytosis; Gene transfection mechanism; Hepatocytes targeting; Membrane fusion

Indexed keywords

ALPHA FETOPROTEIN; ANDROSTANE DERIVATIVE; ANTISENSE OLIGONUCLEOTIDE; ASIALOFETUIN; ASIALOGLYCOPROTEIN; HEPATITIS B ANTIGEN; LIPOSOME; MACROGOL DERIVATIVE; NIGERICIN; POLIDOCANOL; SITOGLUSIDE; SITOSTEROL DERIVATIVE; WORTMANNIN;

ANIMAL; ARTICLE; CELL CULTURE; CELL NUCLEUS; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; HEPATITIS B VIRUS; HUMAN; IMMUNOLOGY; LIVER CELL; METABOLISM; METHODOLOGY; RAT; TUMOR CELL LINE; WISTAR RAT;

ALPHA-FETOPROTEINS; ANDROSTADIENES; ANIMALS; ASIALOGLYCOPROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HEPATITIS B ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; LIPOSOMES; MICROSCOPY, FLUORESCENCE; NIGERICIN; OLIGONUCLEOTIDES, ANTISENSE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SITOSTEROLS; TRANSFECTION;

EID: 33846182947     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Weyermann J, Lochmann D, Zimmer A. Comparison of antisense oligonucleotide drug delivery systems [J]. J Control Release, 2004,100:411-423.
2. Xu R, Cai K, Zheng D, et al. Molecular therapeutics of HBV [J]. Curr Gene Ther, 2003,3:341-355.
3. Korba BE, Gerin JL. Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro [J]. Antiviral Res, 1995,28:225-242.
4. Yao Z. Hepatitis B Virus-associated Molecular Epidemiology [M]. Beijing: Chinese Medical Science and Technology Press, 1994:1-35.
5. Yan WW, Fei R, Wang WH, et al. Influence of soybean-derived sterylglucoside and amphipathic polyethylene glycol on the cellular delivery and anisotropy of different cationic liposomes [J]. J Peking Univ (Health Sci), 2003,3:324-328.
6. Seglen PO. Preparation of isolated rat liver cells [J]. Methods Cell Biol, 1976,13:29-83.
7. Shi J, Yan WW, Qi XR, et al. Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide [J]. Drug Deliv, 2005,12:349-356.
8. Nakanishi M, Noguchi A. Confocal and probe microscopy to study gene transfection mediated by cationic liposomes with a cationic cholesterol derivative [J]. Adv Drug Deliv Rev, 2001,52:197-207.
9. Kawano K, Nakamura K, Hayashi K, et al. Liver targeting liposomes containing beta-sitosterol glucoside with regard to penetration-enhancing effect on HepG2 cells [J]. Biol Pharm Bull, 2002,25:766-770.
10. Hwang SH, Hayashi K, Takayama K, et al. Liver-targeted gene transfer into a human hepatoblastoma cell line and in vivo by sterylglucoside- containing cationic liposomes [J]. Gene Ther, 2001,8:1276-1280.
11. Kim TW, Kim YJ, Chung H, et al. The role of non-ionic surfactants on cationic lipid mediated gene transfer [J]. J Control Release, 2002,82:455-465.
12. Duzgunes N, Nir S. Mechanisms and kinetics of liposome-cell interactions [J]. Adv Drug Deliv Rev, 1999,40:3-18.