Saponins from Tribulus terrestris L. are less toxic for normal human fibroblasts than for many cancer lines: Influence on apoptosis and proliferation

Experimental Biology and Medicine

Volumn 232, Issue 1, 2007, Pages 126-133

  Neychev, V K ^a   Nikolova, E ^a   Zhelev, N ^b   Mitev, V I ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b UNIVERSITY OF ABERTAY DUNDEE   (United Kingdom)

Author keywords

Cytotoxicity; Fibroblast; Saponins; Tribulus terrestris L.

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCASPASE 3; PROTODIOSCIN; PUTRESCINE; SAPONIN DERIVATIVE; SPERMIDINE; SPERMINE; STRESS ACTIVATED PROTEIN KINASE; THYMIDINE; TRIBULUS TERRESTRIS EXTRACT; UNCLASSIFIED DRUG;

ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; CYTOTOXICITY; DEPHOSPHORYLATION; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; FEMALE; FIBROBLAST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; INCUBATION TIME; INTRACELLULAR SPACE; MALE; NORMAL HUMAN; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRIBULUS TERRESTRIS;

ACTINS; APOPTOSIS; CASPASE 3; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FIBROBLASTS; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; PUTRESCINE; SAPONINS; SIGNAL TRANSDUCTION; SPERMIDINE; SPERMINE; TETRAZOLIUM SALTS; THIAZOLES; THYMIDINE; TIME FACTORS; TRIBULUS; TRITIUM;

ANIMALIA; TRIBULUS TERRESTRIS;

EID: 33846154268     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Med 68:297-301, 2002.
2. Hu K, Yao X. The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro. Cancer Invest 21:389-393, 2003.
3. Jiang Y, Wang N, Yao X, Susumu K. Structural elucidation of the anticoagulation and anticancer constituents from Allium chinense [in Chinese]. Yao Xue Xue Bao 33:355-361, 1998.
4. Wang SL, Cai B, Cui CB, Liu HW, Wu CF, Yao XS. Diosgenin-3-O-alpha-L- rhamnopyranosyl-(1 -> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway. J Asian Nat Prod Res 6:115-125, 2004.
5. Bedir E, Khan IA, Walker LA. Biologically active steroidal glycosides from Tribulus terrestris. Pharmazie 57:491-493, 2002.
6. Deng Y, Yang L, An SL. Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes [in Chinese]. Di Yi Jun Yi Da Xue Xue Bao 22:1017-1019, 2002.
7. Sun B, Qu W, Bai Z. The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro [in Chinese]. Zhong Yao Cai 26:104-106, 2003.
8. Sun B, Qu WJ, Zhang XL, Yang HJ, Zhuang XY, Zhang P. Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402 [in Chinese]. Zhongguo Zhong Yao Za Zhi 29:681-684, 2004.
9. Cai L, Wu Y, Zhang J, Pei F, Xu Y, Xie S, Xu D. Steroidal saponins from Tribulus terrestris. Planta Med 67:196-198, 2001.
10. De Combarieu E, Fuzzati N, Lovati M, Mercalli E. Furostanol saponins from Tribulus terrestris. Fitoterapia 74:583-591, 2003.
11. Huang JW, Tan CH, Jiang SH, Zhu DY. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res 5: 285-290, 2003.
12. Zhang JD, Cao YB, Xu Z, Sun HH, An MM, Yan L, Chen HS, Gao PH, Wang Y, Jia XM, Jiang YY. In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against fluconazole-resistant fungal. Biol Pharm Bull 28: 2211-2215, 2005.
13. Gauthaman K, Ganesan AP, Prasad RN. Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model. J Altern Complement Med 9:257-265, 2003.
14. Gyulemetova R, Tomova M, Simova M, Pangarova T, Peeva S. Determination of furostanol saponins in the preparation tribestan. Pharmazie 37:296, 1982.
15. Ganzera M, Bedir E, Khan IA. Determination of steroidal saponins in Tribulus terrestris by reversed-phase high performance liquid chromatography and evaporative light scattering detection. J Pharm Sci 90: 1752-1758, 2001.
16. Villa P, Kaufmann SH, Earnshaw WC. Caspases and caspase inhibitors. Trends Biochem Sci 22:388-393, 1997.
17. MAPK pathway. J Biol Chem 271:20608-20616, 1996.
18. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
19. Efimova T, Broome AM, Eckert RL. Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol 24:8167-8183, 2004.
20. Sun H, Tonks NK, Bar-Sagi D. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science 266:285-288, 1994.
21. Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22:667-676, 1999.
22. Aoki H, Kang PM, Hampe J, Yoshimura K, Noma T, Matsuzaki M, Izumo S. Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 277: 10244-10250, 2002.
23. Lin A, Dibling B. The true face of JNK activation in apoptosis. Aging Cell 1:112-116, 2002.
24. Migliaccio A, Di Domenico M, Castoria G, de Falco A, Bontempo P, Nola E, Auricchio F. EMBO J 15:1292-1300, 1996.
25. Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A, Auricchio F. EMBO J 18:2500-2510, 1999.
26. Woldemichael GM, Wink M. Identification and biological activities of triterpenoid saponins from Chenopodium quinoa. J Agric Food Chem 49:2327-2332, 2001.
27. Stefanelli C, Bonavita F, Stanic I, Pignatti C, Flamigni F, Guarnieri C, Caldarera CM. Spermine triggers the activation of caspase-3 in a cell-free model of apoptosis. FEBS Lett 451:95-98, 1999.
28. Ray RM, Viar MJ, Yuan Q, Johnson LR. Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Am J Physiol Cell Physiol; 278:C480-489, 2000.
29. Poulin R, Pelletier G, Pegg AE. Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase overproducing L1210 cells. Biochem J 311:723-727, 1995.
30. Bhattacharya S, Ray RM, Viar MJ, Johnson LR. Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol 285:G980-991, 2003.
31. Monti MG, Ghiaroni S, Pernecco L, Barbieri D, Marverti G, Franceschi C. Polyamine depletion protects HL-60 cells from 2-deoxy-d-ribose-induced apoptosis. Life Sci 62:799-806, 1998.
32. Monti MG, Ghiaroni S, Barbieri D, Franceschi C, Marverti G, Moruzzi MS. 2-deoxy-d-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine. Biochem Biophys Res Commun 257:460-465, 1999.
33. Kramer DL, Vujcic S, Diegelman P, White C, Black JD, Porter CW. Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway. Biochem Soc Trans 26:609-614, 1998.