New C25 carbamate rifamycin derivatives are resistant to inactivation by ADP-ribosyl transferases

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 2, 2007, Pages 522-526

  Combrink, Keith D ^a   Denton, Daniel A ^a   Harran, Susan ^a   Ma, Zhenkun ^a   Chapo, Katrina ^a   Yan, Dalai ^a   Bonventre, Eric ^a   Roche, Eric D ^a   Doyle, Timothy B ^a   Robertson, Gregory T ^a   Lynch, Anthony S ^a  

^a Cumbre Pharmaceuticals Inc   (United States)

Author keywords

ADP ribosyl transferase; Inactivation; Mycobacterium smegmatis; Rifamycin

Indexed keywords

ACETIC ACID; ALCOHOL; CARBAMIC ACID DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RIFAMPICIN; RIFAMYCIN DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; ENZYME INACTIVATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADP RIBOSE TRANSFERASES; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM SMEGMATIS; PSEUDOMONAS AERUGINOSA; RIFAMPIN; RIFAMYCINS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM SMEGMATIS;

EID: 33846114721     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.016     Document Type: Article

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