Tracking the physical aging of poly(ethylene oxide): A technical note

AAPS PharmSciTech

Volumn 7, Issue 4, 2006, Pages

  Kiss, Dorottya ^a   Süvegh, Karoly ^b   Marek, Tamas ^b   Dévényi, Laszlo ^c   Novák, Csaba ^c   Zelkó, Romána ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

Amorphous; Differential scanning calorimetry; Physical aging; Poly(ethylene oxide); Positron annihilation lifetime spectroscopy

Indexed keywords

EXCIPIENT; MACROGOL; DRUG CARRIER; MACROGOL DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; MATERIALS TESTING; SCANNING ELECTRON MICROSCOPY; SPECTROSCOPY; THERMOSTABILITY; VISCOELASTICITY; CHEMISTRY; DRUG STABILITY; DRUG STORAGE; METHODOLOGY; POROSITY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; MATERIALS TESTING; POLYETHYLENE GLYCOLS; POROSITY; SPECTRUM ANALYSIS;

EID: 33846097608     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070495     Document Type: Article

References (16)

1. Rowe RC, Sheskey PJ, Weller PJ, eds. Handbook of Pharmaceutical Excipients. 4th ed. London, UK: Pharmaceutical Press; 2003: 460-461.
2. Hutchinson JM. Physical aging of polymers. Prog Polym Sci. 1995;20:703-760.
3. Hay JN. The physical ageing of amorphous and crystalline polymers. Pure Appl Chem. 1995;67:1855-1858.
4. Süvegh K, Zelkó R. Physical aging of poly(vinylpyrrolidone) under different humidity conditions. Macromolecules. 2002;35: 795-800.
5. Zelkó R, Süvegh K. Comparison of the enthalpy recovery and free volume of poly(vinylpyrrolidone) during anomalous glassy to rubbery transition. Eur J Pharm Sci. 2004;21:519-523.
6. MacKenzie IK. Experimental Methods of Annihilation Time and Energy Spectrometry. In: Brandt W, Dupasquier A, eds. Positron Solid-State Physics. Amsterdam, The Netherlands: Elsevier; 1983:196-264.
7. Süvegh K, Vértes A, Hyodo T. Positronium as a sensitive detector of changes in molecular structure. Adv Mol Struct Res. 1999;5: 313-357.
8. Zelkó R, Süvegh K. Correlation between the release characteristics of theophylline and the free volume of polyvinylpyrrolidone. Eur J Pharm Sci. 2005;24:351-354.
9. Vernel J, Rychwalski RW, Pelisek V, Saha P, Schmidt M, Maurer FHJ. Physical aging in poly(ethylene oxide)/atactic-poly(methyl methacrylate) blends. Thermochim Acta. 1999;342:115-137.
10. Zhao Y, Jasse B, Monnerie L. Orientation and relaxation in uniaxially stretched poly(methyl methacrylate)-poly(ethylene oxide) blends. Polym J. 1989;30:1643-1650.
11. Jin X, Zhang S, Runt J. Observation of a fast dielectric relaxation in semi-crystalline poly(ethylene oxide). Polym J. 2002;43: 6247-6254.
12. FDA/CDER. Guidance for Industry: Q1A(R2) Stability Testing of New Drug Substances and Products. Rockville, MD: Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research, Food and Drug Administration; 2003.
13. Committee for Proprietary Medicinal Products. Guideline on Stability Testing of Existing Active Substances and Related Finished Products. London, UK: The European Agency for the Evaluation of Medicinal Products; December 17, 2003. CMP/QWP/122/02 revl.
14. Wunderlich B. Crystal Melting: Macromolecular Physics. Vol 3. New York, NY: Academic Press; 1980.
15. Bamford D, Reiche A, Dlubek G, Alloin F, Sanchez J-Y, Alam MA. Ionic conductivity, glass transition, and local free volume in poly (ethylene oxide) electrolytes: single and mixed ion conductors. J Chem Phys. 2003;118:9420-9432.
16. Netti PA, Ambrosio L, Del Nobile MA, Mensitieri G, Nicolais L. Water transport in hyaluronic acid esters. J Bioact Compat Polym. 1996;11:312-316.