Mechanistic investigation of drug release from asymmetric membrane tablets: Effect of media gradients (osmotic pressure and concentration), and potential coating failures on in vitro release

Pharmaceutical Research

Volumn 24, Issue 2, 2007, Pages 288-297

  Am Ende, Mary Tanya ^a   Miller, Lee A ^a  

^a PFIZER INC   (United States)

Author keywords

Asymmetric membrane tablets; Controlled release; In vitro performance; Intentional defects in coating; Osmotic and diffusional drug delivery

Indexed keywords

ACETONE; CAPROMORELIN; CELLULOSE ACETATE; FUMARIC ACID; LIPID; MACROGOL; MAGNESIUM STEARATE; MANNITOL; MICROCRYSTALLINE CELLULOSE; SUCROSE; WATER;

ARTICLE; CONCENTRATION (PARAMETERS); DISSOLUTION; DRUG DOSAGE FORM; DRUG RELEASE; DRUG SOLUBILITY; FILM COATING; FOOD; IN VITRO STUDY; LIPID DIET; OSMOTIC PRESSURE; PRIORITY JOURNAL; SOLUTION AND SOLUBILITY; TABLET;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY FATS; DIFFUSION; DOSAGE FORMS; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; OSMOTIC PRESSURE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SUCROSE; TABLETS; UREA;

EID: 33846082721     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9142-y     Document Type: Article

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