Estrogenic effects of a methanol extract of the fruit of Brenania brieyi de Wild (Rubiaceae)

Journal of Natural Medicines

Volumn 61, Issue 1, 2007, Pages 86-89

  Magne Ndé, Chantal ^a   Njamen, Dieudonné ^a   Mbanya, Jean Claude ^a   Zierau, Oliver ^b   Vollmer, Günter ^b   Fomum, Zacharias Tanee ^a  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Brenania brieyi; Estrogenicity; Methanolic extract; Uterotrophy

Indexed keywords

METHANOL; NATURAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRENANIA BRIEYI; DRUG EFFECT; DRUG MECHANISM; ESTROGEN ACTIVITY; FEMALE; FRUIT; MEDICINAL PLANT; NONHUMAN; RAT; UTERUS WEIGHT; VAGINA EPITHELIUM;

EID: 33846080730     PISSN: 13403443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11418-006-0022-x     Document Type: Article

References (17)

1. World Health Organisation (1996) Research on menopause. Prog Hum Reprod Res 40:1-8
2. Writing Group for the Women's Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Womeńs Health Initiative randomized control trial. JAMA 288:321-333
3. Million Women Study Collaborators (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362:419-427
4. Krishnan V, Heath H, Bryant HU (2000) Mechanism of action of estrogens and selective estrogen receptor modulators. Vitam Horm 60:123-147
5. Cos P, De Bruyne T, Apers S, Vanden Berghe D, Pieters L, Vlietinck AJ (2003) Phytoestrogens: recent developments. Planta Med 69:589-599
6. Adlercreutz CH, Goldin BR, Gorbach SL, Hockerstedt KA, Watanabe S, Hamalainen EK, Markkanen MH, Makela TH, Wahala KT, Adlercreutz T (1995) Soybean phytoestrogen intake and cancer risk. J Nutr 125:757S-770S
7. Constantinou AI, Metha RG, Vaughan A (1996) Inhibition of N-methyl-nitrosourea-induced mammary tumours in rats by the soybean isoflavones. Anticancer Res 16:3293-3298
8. Fritz WA, Coward L, Wang J, Lamartiniere CA (1998) Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19:2151-2158
9. Lamartiniere CA, Zhang XJ, Cotrones MS (1998) Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity. Am Clin Nutr 68(Suppl 6):1400S-1405S
10. Allred CD, Ju YH, Allred KF, Chang J, Helferich WG (2001) Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22:1667-1673
11. Menu P, Bouquet A, Cave A, Pousset JL (1976) Preliminary study of saponosides of the fruits of Brenania Brieyi de Wild. Ann Pharm Fr (APFRAD) 34:427-438
12. Morali G, Polatti F, Metelitsa EN, Mascarucci P, Magnani P, Marre GB (2006) Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. Arzneimittelforschung 56:230-238
13. Mainini G, Scaffa C, Rotondi M, Messalli EM, Quirino L, Ragucci A (2005) Local estrogen replacement therapy in postmenopausal atrophic vaginitis: efficacy and safety of low dose 17 beta-estradiol vaginal tablets. Clin Exp Obstet Gynecol 32:111-113
14. Kurman RJ, Kaminski PF, Norris HJ (1985) The behaviour of endometrial hyperplasia: a long-term study of untreated hyperplasia in 170 patients. Cancer 56:403-412
15. Persson I (1985) The risk of endometrial and breast cancer after estrogen treatment. A review of epidemiological studies. Acta Obstet Gynecol Scand 130(Suppl):59-66
16. Diel P, Smolnikar K, Schulz T, Laudenbach-Leschowski U, Vollmer G (2001) Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium. Hum Reprod 16:997-1006
17. Diel P, Thomae RB, Caldarelli A, Schmidt S, Laudenbach-Leschowski U, Vollmer G (2004) The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and endometrial proliferation is associated with substance specificity of uterine gene expression. Mol Cell Endocrinol 221:21-32