Design and synthesis of 2-methylthio-3-substituted-5,6-dimethylthieno [2,3-d] pyrimidin-4(3H)-ones as analgesic, anti-inflammatory and antibacterial agents

Medicinal Chemistry

Volumn 3, Issue 1, 2007, Pages 67-73

  Alagarsamy, V ^a   Solomon, V Raja ^b   Meena, R ^c   Ramaseshu, K V ^c   Thirumurugan, K ^c   Murugesan, S ^a  

^a ARULMIGU KALASALINGAM COLLEGE OF PHARMACY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

^c K M COLLEGE OF PHARMACY   (India)

Author keywords

Analgesic; Anti inflammatory; Bioisosterism; Thienopyrimidine

Indexed keywords

(2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)DITHIOCARBAMIC ACID METHYL ESTER; 1 (4 CHLOROPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 METHYLPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (4 NITROPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 (DIPHENYL) 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 DIETHYL 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 DIMETHYL 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 METHYL 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 MORPHOLINYL 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 PIPERAZINYL 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 1 PYRROLIDINYL 3 (2 METHYLTHIO 4 OXO 3H 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 3 YL)THIOUREA; 2 AMINO 3 CARBETHOXY 4,5 DIMETHYLTHIOPHENE; 3 AMINO 2 MERCAPTO 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDINE 4(3H) ONE; 3 AMINO 2 METHYLTHIO 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDINE 4(3H) ONE; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; DICLOFENAC; METHYL N (3 CARBETHOXY 4,5 DIMETHYLTHIENYL)DITHIOCARBAMATE; NONSTEROID ANTIINFLAMMATORY AGENT; THIENO[2,3 D]PYRIMIDIN 4 ONE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL INFECTION; CLINICAL PRACTICE; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; EDWARDSIELLA TARDA; INFLAMMATION; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PAIN; PAW EDEMA; PRESCRIPTION; PRIORITY JOURNAL; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; RAT; SALMONELLA PARATYPHI; SALMONELLA TYPHIMURIUM;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIA; CARRAGEENAN; DRUG DESIGN; EDEMA; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PAIN MEASUREMENT; PYRIMIDINONES; RATS; REACTION TIME; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; THIOUREA;

EID: 33846080198     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607779317599     Document Type: Article

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