Contribution of sensitivity, volume and tone to visceral perception in the upper gastrointestinal tract in man: Emphasis on testing

Neurogastroenterology and Motility

Volumn 19, Issue SUPPL.1, 2007, Pages 47-61

  Gregersen, H ^a,b,c,d   Kwiatek, M A ^e,f   Schwizer, W ^e   Tutuian, R ^e  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^d LA JOLLA BIOENGINEERING INSTITUTE   (United States)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Accommodation; Distension; Heartburn; Motility; Oesophagus; Sensitivity; Stomach; Symptoms; Tone; Visceral pain; Volume

Indexed keywords

EDROPHONIUM; PROTON PUMP INHIBITOR;

ACCOMMODATION; AUTONOMIC NERVOUS SYSTEM; BAROSTAT; CLINICAL ASSESSMENT; CONFERENCE PAPER; ECHOGRAPHY; ESOPHAGUS; GASTROINTESTINAL SYMPTOM; HUMAN; IMPEDANCE; INTESTINE CONTRACTION; INTESTINE DISTENSION; METHODOLOGY; MONITORING; MOTOR DEVELOPMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PERCEPTION; PH; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SENSORY ANALYSIS; SENSORY SYSTEM EXAMINATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STOMACH VOLUME; THREE DIMENSIONAL IMAGING; UPPER GASTROINTESTINAL TRACT; VISCERAL PAIN;

DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM; ESOPHAGUS; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRACT; HUMANS; HYDROGEN-ION CONCENTRATION; MANOMETRY; PAIN THRESHOLD; PLETHYSMOGRAPHY, IMPEDANCE;

EID: 33846074932     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2006.00845.x     Document Type: Conference Paper

References (93)

1. Sandler RS, Stewart WF, Liberman JN, Ricci JA, Zorich NL. Abdominal pain, bloating, and diarrhea in the United States: prevalence and impact. Dig Dis Sci 2000; 45: 1166-71.
2. Russo MW, Wei JT, Thiny MT et al. Digestive and liver diseases statistics, 2004. Gastroenterology 2004; 126: 1448-53.
3. Bochus HL. Abdominal pain. In: Berk JE, ed. Gastroenterology. Philadelphia: WB Saunders, 1985: 22-47.
4. Drewes AM, Gregersen H, Arendt-Nielsen L. Experimental pain in gastroenterology: a reappraisal of human studies. Scand J Gastroenterol 2003; 38: 1115-30.
5. Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ III. Prevalence and clinical spectrum of gastroesophageal reflux: a population based study in Olmsted County, Minnesota. Gastroenterology 1997; 112: 1448-56.
6. Eslick GD, Talley NJ. Non-cardiac chest pain: squeezing the life out of the Australian healthcare system? Med J Aust 2000; 173: 233-4.
7. de Caestecker JS, Blackwell JN, Brown J, Heading RC. The oesophagus as a cause of recurrent chest pain: which patients should be investigated and which tests should be used? Lancet 1985; 2: 1143-6.
8. Pandolfino JE, Kahrilas PJ. AGA technical review on the clinical use of esophageal manometry. Gastroenterology 2005; 128: 209-24.
9. Clouse RE, Richter JE, Heading RC et al. Functional esophageal disorders. In: Drossman DA, ed. Rome II The Functional Gastrointestinal Disorders, 2nd edn. Lawrence KS: Allen Press, 2000: 247-98.
10. Aziz Q, Andersson JL, Valind S et al. Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 1997; 113: 50-9.
11. Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH. Multiple representations of pain in human cerebral cortex. Science 1991; 251: 1355-8.
12. Bernstein LM, Baker LA. A clinical test for esophagitis. Gastroenterology 1958; 34: 760-81.
13. Smith JL, Opekun AR, Larkai E, Graham DY. Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux disease. Gastroenterology 1989; 96: 683-9.
14. Jung B, Steinbach J, Beaumont C, Mittal RK. Lack of association between esophageal acid sensitivity detected by prolonged pH monitoring and Bernstein testing. Am J Gastroenterol 2004; 99: 410-5.
15. Hollis JB, Castell DO. Effects of cholinergic stimulation on human esophageal peristalsis. J Appl Physiol 1976; 40: 40-3.
16. Richter JE, Hackshaw BT, Wu WC, Castell DO. Edrophonium: a useful provocative test for esophageal chest pain. Ann Intern Med 1985; 103: 14-21.
17. Richardson P, Hawkey CJ, Stack WA. Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders. Drugs 1998; 56: 307-35.
18. Fass R, Fennerty MB, Ofman JJ et al. The clinical and economic value of a short course of omeprazole in patients with noncardiac chest pain. Gastroenterology 1998; 115: 42-9.
19. Bautista J, Fullerton H, Briseno M, Cui H, Fass R. The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain - a randomized, double-blind, placebo-controlled, crossover trial. Aliment Pharmacol Ther 2004; 19: 1123-30.
20. Dickman R, Emmons S, Cui H et al. The effect of a therapeutic trial of high-dose rabeprazole on symptom response of patients with non-cardiac chest pain: a randomized, double-blind, placebo-controlled, crossover trial. Aliment Pharmacol Ther 2005; 22: 547-55.
21. Gregersen H, Stodkilde-Jorgensen H, Djurhuus JC, Mortensen SO. The four-electrode impedance technique: a method for investigation of compliance in luminal organs. Clin Phys Physiol Meas 1988; 9 (Suppl. A): 61-4.
22. Orvar KB, Gregersen H, Christensen J. Biomechanical characteristics of the human esophagus. Dig Dis Sci 1993; 38: 197-205.
23. Drewes AM, Schipper KP, Dimcevski G et al. Multimodal assessment of pain in the esophagus: a new experimental model. Am J Physiol 2002; 283: G95-103.
24. Pedersen J, Reddy H, Funch-Jensen P, Arendt-Nielsen L, Gregersen H, Drewes AM. Cold and heat pain assessment of the human oesophagus after experimental sensitisation with acid. Pain 2004; 110: 393-9.
25. Drewes AM, Reddy H, Pedersen J, Funch-Jensen P, Gregersen H, Arendt-Nielsen L. Multimodal pain stimulations in patients with grade B oesophagitis. Gut 2006; 55: 926-32.
26. Silny J. Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil 1991; 3: 151-62.
27. Sifrim D, Castell D, Dent J, Kahrilas PJ. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004; 53: 1024-31.
28. Shay S, Tutuian R, Sifrim D et al. Twenty-four hour ambulatory simultaneous impedance and pH monitoring: a multicenter report of normal values from 60 healthy volunteers. Am J Gastroenterol 2004; 99: 1037-43.
29. Zerbib F, des Varannes SB, Roman S et al. Normal values and day-to-day variability of 24-h ambulatory oesophageal impedance-pH monitoring in a Belgian-French cohort of healthy subjects. Aliment Pharmacol Ther 2005; 22: 1011-21.
30. Zentilin P, Iiritano E, Dulbecco P et al. Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet. Dig Liver Dis 2006; 38: 226-32.
31. Mainie I, Tutuian R, Shay S et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy. A multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006; 55: 1398-402 (Epub ahead of print).
32. Tutuian R, Mainie I, Agrawal A, Castell DO. Characteristics of symptomatic reflux episodes on acid suppressive therapy. Gut 2005; 54 (Suppl. VII): A103 (Abstract).
33. Balaban DH, Yamamoto Y, Liu J et al. Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology 1999; 116: 29-37.
34. Pehlivanov N, Liu J, Mittal RK. Sustained esophageal contraction: a motor correlate of heartburn symptom. Am J Physiol 2001; 281: G743-51.
35. Kramer P, Hollander W. Comparison of experimental esophageal pain with clinical pain of angina pectoris and esophageal disease. Gastroenterology 1955; 29: 719-43.
36. Richter JE, Barish CF, Castell DO. Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986; 91: 845-52.
37. Fass R. Provocative tests for pain of esophageal origin. In: Castell DO, Richter JE, eds. The Esophagus, 4th edn. New York: Lippincot Williams & Wilkings, 2004: 165-83.
38. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ III. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 1992; 102: 1259-68.
39. El-Serag HB, Talley NJ. Systemic review: the prevalence and clinical course of functional dyspepsia. Aliment Pharmacol Ther 2004; 19: 643-54.
40. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346-52.
41. Tack J, Caenepeel P, Corsetti M, Janssens J. Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention. Gastroenterology 2004; 127: 1058-66.
42. Gregersen H, Drewes AM, Gilja OH. Tension receptors: theoretical construct or fact? Gastroenterology 2005; 128: 803-4 author reply 804-5.
43. Mundt MW, Hausken T, Samsom M. Effect of intragastric barostat bag on proximal and distal gastric accommodation in response to liquid meal. Am J Physiol 2002; 283: G681-6.
44. Rao SS, Vemuri S, Harris B, Schulze K. Fundic balloon distension stimulates antral and duodenal motility in man. Dig Dis Sci 2002; 47: 1015-9.
45. O'Connor MK, O'Connell R, Keane FB, Byrne PJ, Hennessy TP. The relationship between technetium 99 m pertechnetate gastric scanning and gastric contents. Br J Radiol 1983; 56: 817-22.
46. Kuiken SD, Samsom M, Camilleri M et al. Development of a test to measure gastric accommodation in humans. Am J Physiol 1999; 277: G1217-21.
47. Liau SS, Camilleri M, Kim DY, Stephens D, Burton DD, O'Connor MK. Pharmacological modulation of human gastric volumes demonstrated noninvasively using SPECT imaging. Neurogastroenterol Motil 2001; 13: 533-42.
48. Bouras EP, Delgado-Aros S, Camilleri M et al. SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Single photon emission computed tomography. Gut 2002; 51: 781-6.
49. Bredenoord AJ, Chial HJ, Camilleri M, Mullan BP, Murray JA. Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms. Clin Gastroenterol Hepatol 2003; 1: 264-72.
50. Burton DD, Kim HJ, Camilleri M et al. Relationship of gastric emptying and volume changes after a solid meal in humans. Am J Physiol 2005; 289: G261-6.
51. Marzio L, Falcucci M, Grossi L et al. Proximal and distal gastric distension in normal subjects and H. pylori-positive and -negative dyspeptic patients and correlation with symptoms. Dig Dis Sci 1998; 43: 2757-63.
52. Hausken T, Berstad A. Wide gastric antrum in patients with non-ulcer dyspepsia. Effect of cisapride. Scand J Gastroenterol 1992; 27: 427-32.
53. Gilja OH, Hausken T, Odegaard S, Berstad A. Three-dimensional ultrasonography of the gastric antrum in patients with functional dyspepsia. Scand J Gastroenterol 1996; 31: 847-55.
54. Gilja OH, Detmer PR, Jong JM et al. Intragastric distribution and gastric emptying assessed by three-dimensional ultrasonography. Gastroenterology 1997; 113: 38-49.
55. Mundt MW, Samsom M. Fundal dysaccommodation in functional dyspepsia: head-to-head comparison between the barostat and 3D ultrasonographic technique. Gut 2006; (in press).
56. Schwizer W, Fraser R, Borovicka J, Crelier G, Boesiger P, Fried M. Measurement of gastric emptying and gastric motility by magnetic resonance imaging (MRI). Dig Dis Sci 1994; 39: 101s-3.
57. Schwizer W, Maecke H, Fried M. Measurement of gastric emptying by magnetic resonance imaging in humans. Gastroenterology 1992; 103: 369-76.
58. Schwizer W, Steingotter A, Fox M et al. Non-invasive measurement of gastric accommodation in humans. Gut 2002; 51 (Suppl. 1): i59-62.
59. Schwizer W, Fraser R, Borovicka J et al. Measurement of proximal and distal gastric motility with magnetic resonance imaging. Am J Physiol 1996; 271: G217-22.
60. Fruehauf H, Goetze O, Steingoetter A et al. Inter- and intrasubject variability of total gastric volumes in response to isocaloric liquid meals in functional dyspepsia and health. Gastroenterology 2005; 128 (Suppl. 2): A545.
61. Goetze O, Steingoetter A, Menne D et al. The effect of macronutrients on gastric volume responses and gastric emptying in humans - a magnetic resonance imaging study. Am J Physiol 2006; (in press).
62. Kwiatek MA, Steingoetter A, Pal A et al. Quantification of distal antral contractile motility in healthy human stomach with magnetic resonance imaging. J Magn Reson Imaging 2006; 24: 1101-9.
63. Marciani L, Gowland PA, Fillery-Travis A et al. Assessment of antral grinding of a model solid meal with echoplanar imaging. Am J Physiol 2001; 280: G844-9.
64. Marciani L, Gowland PA, Spiller RC et al. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am J Physiol 2001; 280: G1227-33.
65. Treier R, Steingoetter A, Goetze O, Boesiger P, Fried M, Schwizer W. Quantitative and non-invasive assessment of postprandial intragastric dilution as assessed by magnetic resonance imaging (MRI). Gastroenterology 2006; 130: A194.
66. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada JR. Gastric tone determines the sensitivity of the stomach to distention. Gastroenterology 1995; 108: 330-6.
67. Distrutti E, Azpiroz F, Soldevilla A, Malagelada JR. Gastric wall tension determines perception of gastric distention. Gastroenterology 1999; 116: 1035-42.
68. Mearin F, Cucala M, Azpiroz F, Malagelada JR. The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 1991; 101: 999-1006.
69. Boeckxstaens GE, Hirsch DP, van den Elzen BD, Heisterkamp SH, Tytgat GN. Impaired drinking capacity in patients with functional dyspepsia: relationship with proximal stomach function. Gastroenterology 2001; 121: 1054-63.
70. Salet GA, Samsom M, Roelofs JM, van Berge Henegouwen GP, Smout AJ, Akkermans LM. Responses to gastric distension in functional dyspepsia. Gut 1998; 42: 823-9.
71. Holtmann G, Gschossmann J, Neufang-Huber J, Gerken G, Talley NJ. Differences in gastric mechanosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controls. Gut 2000; 47: 332-6.
72. Boeckxstaens GE, Hirsch DP, Kuiken SD, Heisterkamp SH, Tytgat GN. The proximal stomach and postprandial symptoms in functional dyspeptics. Am J Gastroenterol 2002; 97: 40-8.
73. Ladabaum U, Koshy SS, Woods ML, Hooper FG, Owyang C, Hasler WL. Differential symptomatic and electrogastrographic effects of distal and proximal human gastric distension. Am J Physiol 1998; 275: G418-24.
74. Lee KJ, Vos R, Janssens J, Tack J. Differences in the sensorimotor response to distension between the proximal and distal stomach in humans. Gut 2004; 53: 938-43.
75. van den Elzen BD, Bennink RJ, Wieringa RE, Tytgat GN, Boeckxstaens GE. Fundic accommodation assessed by SPECT scanning: comparison with the gastric barostat. Gut 2003; 52: 1548-54.
76. Kim DY, Delgado-Aros S, Camilleri M et al. Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia. Am J Gastroenterol 2001; 96: 3099-105.
77. Goetze O, Menne D, Kwiatek M et al. Modelling of gastric volume data to assess gastric accommodation and emptying following ingestion of liquid meals. Neurogastroenterol Motil 2005; 17 (Suppl. 2): 29.
78. Malagelada JR. The quest for a physiological answer to dyspepsia. Gastroenterology 1998; 115: 1586-8.
79. Liao D, Gregersen H, Hausken T, Gilja OH, Mundt M, Kassab G. Analysis of surface geometry of the human stomach using real-time 3-D ultrasonography in vivo. Neurogastroenterol Motil 2004; 16: 315-24.
80. Gregersen H, Christensen J. Gastrointestinal tone. Neurogastroenterol Motil 2000; 12: 501-8.
81. Moritz F. Studien uber die motorische Thatigkeit des Magens. Zeitschr fur Biol 1895; 32: 313-69.
82. Cannon WB, Lieb CW. The receptive relaxation of the stomach. Am J Physiol 1911; 29: 267-73.
83. Grey EG. Observations on the postural activity of the stomach. Am J Physiol 1918; 45: 272-85.
84. Azpiroz F, Malagelada JR. Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol 1985; 248: G229-37.
85. Jahnberg T, Abrahamsson H, Jansson G, Martinson J. Gastric relaxatory response to feeding before and after vagotomy. Scand J Gastroenterol 1977; 12: 225-8.
86. Desai KM, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 1991; 351: 477-9.
87. Gilja OH, Hausken T, Wilhelmsen I, Berstad A. Impaired accommodation of proximal stomach to a meal in functional dyspepsia. Dig Dis Sci 1996; 41: 689-96.
88. De Schepper HU, Cremonini F, Chitkara D, Camilleri M. Assessment of gastric accommodation: overview and evaluation of current methods. Neurogastroenterol Motil 2004; 16: 275-85.
89. Azpiroz F, Malagelada JR. Intestinal control of gastric tone. Am J Physiol 1985; 249: G501-9.
90. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 2001; 121: 526-35.
91. Ropert A, des Varannes SB, Bizais Y, Roze C, Galmiche JP. Simultaneous assessment of liquid emptying and proximal gastric tone in humans. Gastroenterology1993;105:667-74.
92. Elashoff J, Reedy T, Meyer J. Analysis of gastric emptying data. Gastroenterology 1982; 83: 1306-12.
93. Drewes AM, Schipper KP, Dimcevski G et al. Multi-modal induction and assessment of allodynia and hyperalgesia in the human oesophagus. Eur J Pain 2003; 7: 539-49.