Catalytic asymmetric synthesis of ethyl (1R,2S)-dehydrocoronamate

Tetrahedron Letters

Volumn 48, Issue 6, 2007, Pages 945-948

  Fox, Martin E ^a   Lennon, Ian C ^a   Farina, Vittorio ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

3,4 Epoxy 1 butene; Allylic alkylation; Amino acids; Asymmetric catalysis; Palladium

Indexed keywords

1,2 EPOXY 3 BUTENE; ANION; DEHYDROCORONAMIC ACID ETHYL ESTER; ESTER DERIVATIVE; GLYCINE; HYDROXYL GROUP; LIGAND; NAPHTHALENE; PALLADIUM; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC CATALYSIS; ASYMMETRIC SYNTHESIS; CATALYSIS; CHEMICAL REACTION; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY;

EID: 33846062525     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.12.025     Document Type: Article

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14. Sample: N-TFA derivative in ethyl acetate. Column: Chiraldex ATA 30 m × 0.25 mm. Carrier gas: Helium at 14 psi. Detection: FID at 200 °C. Injector temperature: 200 °C. Oven temperature: 60 °C for 5 min to 170 °C at 10 °C/min, hold for 5 min. Retention times: (1R,2S) 15.50 min; (1S,2R) 16.09 min.
15. By comparison with a sample made by methods described in Ref. 2.