Asymmetric palladium(0) catalyzed tandem alkylation and SN′ cyclization of 1,4-dichlorobut-2-ene by chiral imines of aminoacetonitrile for the total synthesis of 1-aminocyclopropanecarboxylic acids

Synlett

Volumn , Issue 5, 1998, Pages 483-486

  Dorizon, Philippe ^a   Su, Guifa ^a   Ludvig, Guitte ^a   Nikitina, Lilyia ^a   Ollivier, Jean ^a   Salaün, Jacques ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002433821     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-1687     Document Type: Article

References (36)

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11. 3).
12. N′ cyclization of E -and Z-1 by racemic imine 2, required two equiv of NaH, but with the imines (-)- and (+)-8a derived from (-)- and (+)-hydroxypinanones, respectively, at least three equiv of base were obviously required.
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14. 3).
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27. 3]; the others were based on HPLC chromatography (1) or on X-ray analysis (1).
28. 2, 55°C) two peaks at 52.75 (34%) and 55.83 (66%) min; while after re-treatment in the presence of (R)-BINAP-Pd(0), E-13a (9% ee) displayed two peaks at 52.74 (55%) and 56 (45%) min.
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