A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype

Toxicology Letters

Volumn 168, Issue 2, 2007, Pages 148-154

  Ogawa, Masanori ^a,b   Oyama, Tsunehiro ^a   Isse, Toyohi ^a   Saito, Koichi ^c   Tomigahara, Yoshitaka ^c   Endo, Yoko ^b   Kawamoto, Toshihiro ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b TOKYO ROSAI HOSPITAL   (Japan)

^c SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Alcohol; ALDH2; DNA adduct; Knock out mouse; Polymorphism

Indexed keywords

ALCOHOL;

ALCOHOL CONSUMPTION; ALDH2 GENE; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; COMPARATIVE STUDY; COVALENT BOND; DNA ADDUCT; DNA BINDING; GENE; GENETIC POLYMORPHISM; GENOTYPE; KIDNEY; KNOCKOUT MOUSE; LIQUID SCINTILLATION COUNTING; LIVER; MALE; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; RADIOACTIVITY; STOMACH; WILD TYPE;

ALDEHYDE DEHYDROGENASE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DNA ADDUCTS; ETHANOL; GENOTYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYMORPHISM, GENETIC; TISSUE DISTRIBUTION;

MUS;

EID: 33846057813     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.11.010     Document Type: Article

References (21)

1. Brien J.F., and Loomis C.W. Pharmacology of acetaldehyde. Can. J. Physiol. Pharmacol. 61 (1983) 1-22
2. Chen C., Mann J., and Yoshida A. Transgenesis of the aldehyde dehydrogenase-2 (ALDH2) locus in a mouse model and in cultured human cells. Adv. Exp. Med. Biol. 372 (1995) 131-136
3. Fang J.L., and Vaca C.E. Development of a 32P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2′-deoxyguanosine-3′-monophosphate and DNA. Carcinogenesis 16 (1995) 2177-2185
4. Harada S., Misawa S., Agarwal D.P., and Goedde H.W. Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese isozyme variation and its possible role in alcohol intoxication. Am. J. Hum. Genet. 32-41 (1980) 8-15
5. Harada S. Genetic polymorphism of alcohol metabolizing enzymes and its implication to human ecology. J. Anthrop. Soc. Nippon 99 (1991) 123-139
6. Helman E.Z., Spiehler V., and Holland S. Elimination of error caused by hemolysis and bilirubin-induced color quenching in clinical radioimmunoassays. Clin. Chem. 20 9 (1974) 1187-1193
7. Isse T., Oyama T., Kitagawa K., Matsuno K., Matsumoto A., Yoshida A., Nakayama K., and Nakayama K.-I. Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12 8 (2002) 621-626
8. Isse T., Matsuno K., Oyama T., Kitagawa K., and Kawamoto T. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages. Alcohol Clin. Exp. Res. 11 (2005) 1959-1964
9. Kawamoto T., Matsuno K., Kodama Y., Murata K., and Matsuda S. ALDH2 polymorphism and biological monitoring of toluene. Arch. Environ. Health 49 (1994) 332-336
10. Kawamoto T., Murata K., Koga M., Hattori Y., and Kodama Y. Distribution of urinary hippuric acid concentrations by ALDH2 genotype. Occup. Environ. Med. 51 (1994) 817-821
11. Kawamoto T., Koga M., Murata K., Matsuda S., and Kodama Y. Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol. Appl. Pharmacol. 133 (1995) 295-304
12. Kawamoto T., Isse T., Kunugita N., Yang M., Kitagawa K., Suenaga R., Matsumoto A., and Oyama T. Effects of genetic polymorphism of drug metabolizing enzymes on smoking and drinking. J. UOEH Suppl. 1 (2003) 97-106
13. Kawamoto T., Kitagawa K., Isse T., Matsumoto A., Yamaguchi T., Suzuki R., Ogawa M., Kinaga T., Katsuno K., Kunugita N., and Oyama T. Application of Aldh2 knockout mice to biomedical research of alcohol. Jpn. J. Psychiatr. Res. Alcohol 10 1 (2003) 3-10 (in Japanese)
14. Kitagawa K., Kawamoto T., Kunugita N., Tsukiyama T., Okamoto K., Yoshida A., Nakayama K., and Nakayama K.-I. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 476 (2000) 306-311
15. Lutz W.K. In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat. Res. 65 4 (1979) 289-356
16. Lutz W.K. Quantitative levation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens. J. Cancer Res. Clin. Oncol. 112 (1986) 85-91
17. Muramatsu T., Higuchi S., Shigemori K., Saito M., Sasao M., and Harada S. Ethanol patch test-a simple and sensitive method for identifying ALDH phenotype. Alcohol Clin. Exp. Res. 13 2 (1989) 229-231
18. Muto M., Nakane M., Hitomi Y., Yoshida S., Sasaki S., Ohtsu A., Yoshida S., Ebihara S., and Esumi H. Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer. Carcinogenesis 23 (2002) 1759-1765
19. Sophos N.A., and Vasiliou V. Aldehyde dehydrogenase gene superfamily, 2002 update. Chem. Biol. Interact. 143-144 (2003) 5-22
20. Yokoyama A., Muramatsu T., Ohmori T., Higuchi S., Hayashida M., and Ishii H. Esophageal cancer and aldehyde dehydrogenae-2 genotypes in Japanese males. Cancer Epidemiol. Biomark. Prev. 5 (1996) 99-102
21. Yokoyama A., Muramatsu T., Ohmori T., Yokoyama T., Okuyama K., Takahashi H., Hasegawa Y., Higuchi S., Haruyama K., Shirakusa K., and Ishii H. Alcohol-related cancers and aldehyde dehydrogenae-2 in Japanese alcoholics. Carcinogenesis 19 (1998) 1383-1387