Vitamin B6, B12, and folic acid supplementation and cognitive function: A systematic review of randomized trials

Archives of Internal Medicine

Volumn 167, Issue 1, 2007, Pages 21-30

  Balk, Ethan M ^a   Raman, Gowri ^a   Tatsioni, Athina ^a   Chung, Mei ^a   Lau, Joseph ^a   Rosenberg, Irwin H ^b  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HYDROXOCOBALAMIN; PLACEBO; PYRIDOXINE; VITAMIN B COMPLEX;

CLINICAL EVALUATION; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; REVIEW; SAMPLE SIZE; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; DIET SUPPLEMENTATION; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

COGNITION; COGNITION DISORDERS; DIETARY SUPPLEMENTS; FOLIC ACID; HUMANS; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME; VITAMIN B 12; VITAMIN B 6; VITAMIN B COMPLEX;

EID: 33846037713     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.167.1.21     Document Type: Review

References (52)

1. Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366:2112-2117.
2. Herrmann N. Cognitive pharmacotherapy of Alzheimer's disease and other dementias. Can J Psychiatry. 2002;47:715-722.
3. Wardlaw GM, Kessel M. The Water-Soluble Vitamins: Perspectives in Nutrition. 5th ed. New York, NY: McGraw-Hill; 2002:364-417.
4. Riggs KM, Spiro A III, Tucker K, Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr. 1996;63:306-314.
5. Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology. 2001;56:1188-1194.
6. Balk E, Chung M, Raman G, et al. B Vitamins and Berries and Age-Related Neurodegenerative Disorders: Evidence Report/Technology Assessment No. 134. Rockville, Md: Agency for Healthcare Research and Quality; April 2006.
7. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(suppl 1):S1-S266.
8. Stott DJ, MacIntosh G, Lowe GD, et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr. 2005;82:1320-1326.
9. Bryan J, Calvaresi E, Hughes D. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr. 2002;132:1345-1356.
10. Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl). 1992;109:489-496.
11. Hvas AM, Juul S, Lauritzen L, Nexo E, Ellegaard J. No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study. J Affect Disord. 2004;81:269-273.
12. Seal EC, Metz J, Flicker L, Melny J. A randomized, double-blind, placebo-controlled study of oral vitamin B12 supplementation in older patients with subnormal or borderline serum vitamin B12 concentrations. J Am Geriatr Soc. 2002;50:146-151.
13. Kwok T, Tang C, Woo J, Lai WK, Law LK, Pang CP. Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. Int J Geriatr Psychiatry. 1998;13:611-616.
14. Kral VA, Solyom L, Enesco H, Ledwidge B. Relationship of vitamin B12 and folic acid to memory function. Biol Psychiatry. 1970;2:19-26.
15. Fioravanti M, Ferrario E, Massaia M, et al. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr. 1997;26:1-13.
16. Sommer BR, Hoff AL, Costa M. Folic acid supplementation in dementia: a preliminary report. J Geriatr Psychiatry Neurol. 2003;16:156-159.
17. Lewerin C, Matousek M, Steen G, Johansson B, Steen B, Nilsson-Ehle H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am J Clin Nutr. 2005;81:1155-1162.
18. Clarke R, Harrison G, Richards S; Vital Trial Collaborative Group. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern Med. 2003;254:67-75.
19. Shaw DM, Macsweeney DA, Johnson AL, et al. Folate and amine metabolites in senile dementia: a combined trial and biochemical study. Psychol Med. 1971;1:166-171.
20. Gallo JJ, Breitner JC. Alzheimer's disease in the NAS-NRC Registry of aging twin veterans, IV: performance characteristics of a two-stage telephone screening procedure for Alzheimer's dementia. Psychol Med. 1995;25:1211-1219.
21. Houx PJ, Shepherd J, Blauw GJ, et al. Testing cognitive function in elderly populations: the PROSPER study: PROspective Study of Pravastatin in the Elderly at Risk. J Neurol Neurosurg Psychiatry. 2002;73:385-389.
22. Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio, Tex: Psychological Corp; 1997.
23. Dodrill CB. A neuropsychological battery for epilepsy. Epilepsia. 1978;19:611-623.
24. Benton AL, Hamsher D. Multilingual Aphasia Examination. Iowa City: University of Iowa; 1989.
25. Emmen HH, Hogendijk EMG, Hooisma J, Orlebeke JF, Uijtdehaage SHJ. Adaption of Two Standardized International Test Batteries for Use in the Netherlands for Detection of Exposure to Neurotoxic Compounds: Internal Report. Rijswijk, the Netherlands: Medisch Biologisch Laboratorium TNO; 1988.
26. Folstein MF, Folstein SE, McHugh PR. "Minimental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
27. Roth M, Tym E, Mountjoy CQ, et al. CAMDEX: a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry. 1986;149:698-709.
28. Nielsen H, Lolk A, Krag-Sorensen P. Normative data for eight neuropsychological tests, gathered from a random sample of Danes aged 64-83 years. Nord Psykol. 1995;47:241-255.
29. Eussen SJ, de Groot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr. 2006;84:361-370.
30. Wechsler D. Wechsler Adult Intelligence Scale-Revised Manual. New York, NY: Psychological Corp, Harcourt Brace & Jovanovich; 1982.
31. Houx P. Cognitive Aging and Health-Related Factors. Maastricht, the Netherlands: Maastricht University; 1991.
32. Reitan RM. Trail Making Test: Manual for Administration and Scoring. Tucson, Ariz: Reitan Neuropsychological Laboratory; 1992.
33. Saan RJ, Deelman BJ. New 15-Words Test (A and B): A Manual. Lisse, the Netherlands: Swets & Zeitlinger; 1986.
34. Houx PJ, Jolles J, Vreeling FW. Stroop interference: aging effects assessed with the Stroop Color-Word Test. Exp Aging Res. 1993;19:209-224.
35. Visser RH. Manual of the Complex Figure Test. Lisse, the Netherlands: Swets & Zeitlinger; 1985.
36. Raven J. Guide to Using the Colored Progressive Matrices. London, England: HK Lewis; 1965.
37. Luteijn FvdPF. Manual Groningen Intelligence Test. Lisse, the Netherlands: Swets & Zeitlinger; 1983.
38. Wechsler D. Standardized memory scale for clinical use. J Psychol. 1945;19:87.
39. Cameron DE. Impairment in the retention phase of remembering. Psychiatr Q. 1943;17:395.
40. Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. Philadelphia, Pa: Lea & Febiger; 1983.
41. Benton AL, Hamsher K, Sivan AB. Multilingual Aphasia Examination. Iowa City, Iowa: AJA Associates; 1994.
42. Reitan RM. Clinical Neuropsychology: Current Status and Applications. New York, NY: Hemisphere; 1974.
43. Randt CT, Brown ER. Randt Memory Test. Bayport, NY: Life Science Associates; 1983.
44. McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med. 2006;354:2764-2772.
45. Lezak MD. Neuropsychological Assessment. 3rd ed. New York, NY: Oxford University Press; 1995.
46. Wechsler D. The Measurement and Appraisal of Adult Intelligence. Baltimore, Md: Williams & Wilkins; 1958.
47. Dureman I, Salde H. Psychometric and Experimental Psychological Methods for Clinical Application [in Swedish]. Stockholm, Sweden: Almquist & Wiksell; 1959.
48. Thurstone L. Primary Mental Abilities: Psychometric Monographs. Chicago, Ill: University of Chicago Press; 1938.
49. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984;141:1356-1364.
50. Kendrick DC. A cross-validation study of the use of the SLT and DCT in screening for diffuse brain pathology in elderly subjects. Br J Med Psychol. 1967;40:173-178.
51. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry. 1968;114:797-811.
52. Durga J. Effect of 3-year folic acid supplementation on cognitive function in older adults: a randomized double blind controlled trial [abstract]. J Nutr Health Aging. 2006;10:204-214.