A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance

Journal of Infectious Diseases

Volumn 182, Issue 6, 2000, Pages 1765-1768

  Wilkinson, I B ^d   MacCallum, H ^d   Rooijmans, D F ^d   Murray, G D ^b   Cockcroft, J R ^c   MaKnight, J A ^a   Webb, D J ^d  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; DNA POLYMERASE; FOSCARNET; GANCICLOVIR; MULTIDRUG RESISTANCE PROTEIN; PHOSPHOTRANSFERASE; VIRUS DNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CODON; CONTROLLED STUDY; CYTOMEGALOVIRUS; DELETION MUTANT; DISEASE COURSE; DNA SEQUENCE; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETINITIS; SEQUENCE ANALYSIS; VIRUS ETIOLOGY; VIRUS ISOLATION; VIRUS MUTATION; VIRUS RECOMBINANT; VIRUS RESISTANCE; VIRUS STRAIN;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS RETINITIS; CYTOSINE; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FOSCARNET; GANCICLOVIR; GENE DELETION; HUMANS; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PHOSPHOTRANSFERASES; TRANSFECTION;

EID: 0033680466     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/317618     Document Type: Article

References (13)

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6. Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease
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11. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalcvirus isolates and identification of mutations conferring ganciclovir resistance
12. Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma
13. Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene