A postulated role of garlic organosulfur compounds in prevention of valproic acid hepatotoxicity

Medical Hypotheses

Volumn 68, Issue 3, 2007, Pages 512-514

  Sabayan, Behnam ^a   Foroughinia, Farzaneh ^a   Chohedry, Abdolhamid ^b  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GARLIC EXTRACT; GLUTATHIONE; ORGANOSULFUR DERIVATIVE; REACTIVE OXYGEN METABOLITE; VALPROIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; DRUG SAFETY; DRUG TOLERABILITY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; LIVER CELL; LIVER FUNCTION; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

GARLIC; HUMANS; LIVER; PHYTOTHERAPY; SULFUR COMPOUNDS; VALPROIC ACID;

ALLIUM SATIVUM;

EID: 33846006203     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.07.055     Document Type: Article

References (24)

1. Johannessen C.U., and Johannessen S.I. Valproate: past, present, and future. CNS Drug Rev 9 2 (2003) 199-216
2. Loscher W. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 16 10 (2002) 669-694
3. Peterson G.M., and Naunton M. Valproate: a simple chemical with so much to offer. J Clin Pharm Ther 30 5 (2005) 417-421
4. DeVane C.L. Pharmacokinetics, drug interactions, and tolerability of valproate. Psychopharmacol Bull 37 Suppl 2 (2003) 25-42
5. Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 16 10 (2002) 695-714
6. Buchi K.N., Gray P.D., Rollins D.E., and Tolman K.G. Protection against sodium valproate injury in isolated hepatocytes by alpha-tocopherol and N,N′-diphenyl-P-phenylenediamine. J Clin Pharmacol 24 4 (1984) 148-154
7. Jurima-Romet M., Abbott F.S., Tang W., Huang H.S., and Whitehouse L.W. Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes. Toxicology 112 1 (1996) 69-85
8. 2t-isoprostane in rats. Free Radical Biol Med 34 11 (2003) 1435-1446
9. Tong V., Teng X.W., Chang T.K., and Abbott F.S. Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci 86 2 (2005) 427-435
10. Meister A. Selective modification of glutathione metabolism. Science 220 4596 (1983) 472-477
11. Kaplowitz N., and Tsukamoto H. Oxidative stress and liver disease. Prog Liver Dis 14 (1996) 131-159
12. Tong V., Teng X.W., Chang T.K., and Abbott F.S. Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. Toxicol Sci 86 2 (2005) 436-443
13. Banerjee S.K., Mukherjee P.K., and Maulik S.K. Garlic as an antioxidant: the good, the bad and the ugly. Phytother Res 17 2 (2003) 97-106
14. Prasad K., Laxdal V.A., Yu M., and Raney B.L. Evaluation of hydroxyl radical-scavenging property of garlic. Mol Cell Biochem 154 1 (1996) 55-63
15. Popov I., Blumstein A., and Lewin G. Antioxidant effects of aqueous garlic extract. 1st communication: Direct detection using the photochemiluminescence. Arzneimittelforschung 44 5 (1994) 602-604
16. Maulik G., Maulik N., Bhandari V., Kagan V.E., Pakrashi S., and Das D.K. Evaluation of antioxidant effectiveness of a few herbal plants. Free Radical Res 27 2 (1997) 221-228
17. Ho S.E., Ide N., and Lau B.H. S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process. Phytomedicine 8 1 (2001) 39-46
18. Ide N., and Lau B.H. Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation. J Nutr 131 3s (2001) 1020S-1026S
19. Arivazhagan S., Balasenthil S., and Nagini S. Modulatory effects of garlic and neem leaf extracts on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats. Cell Biochem Funct 18 1 (2000) 17-21
20. Gedik N., Kabasakal L., Sehirli O., Ercan F., Sirvanci S., Keyer-Uysal M., and Sener G. Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats. Life Sci 76 22 (2005) 2593-2606
21. Sener G., Satyroglu H., Ozer Sehirli A., and Kacmaz A. Protective effect of aqueous garlic extract against oxidative organ damage in a rat model of thermal injury. Life Sci 73 1 (2003) 81-91
22. Andorfer J.H., Tchaikovskaya T., and Listowsky I. Selective expression of glutathione S-transferase genes in the murine gastrointestinal tract in response to dietary organosulfur compounds. Carcinogenesis 25 3 (2004) 359-367
23. Tsai C.W., Yang J.J., Chen H.W., Sheen L.Y., and Lii C.K. Garlic organosulfur compounds upregulate the expression of the pi class of glutathione S-transferase in rat primary hepatocytes. J Nutr 135 11 (2005) 2560-2565
24. Fukao T., Hosono T., Misawa S., Seki T., and Ariga T. The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem Toxicol 42 5 (2004) 743-749