α-Methyl-5-HT, a 5-HT2 receptor agonist, stimulates β2-adrenoceptors in guinea pig airway smooth muscle

Pharmacological Research

Volumn 54, Issue 6, 2006, Pages 468-473

  Campos Bedolla, Patricia ^a   Vargas, Mario H ^b   Calixto, Eduardo ^c   Segura, Patricia ^b   Mendoza Patiño, Nicandro ^e   Figueroa, Alejandra ^e   Flores Soto, Edgar ^e   Barajas López, Carlos ^d   Montaño, Luis M ^e  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

^c INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

^d INSTITUTO POTOSINO DE INVESTIGACIÓN CIENTÍFICA Y TECNOLÓGICA   (Mexico)

^e UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Methyl 5 HT; Methyl serotonin; 2 Adrenoceptors; Airway smooth muscle; K+ currents

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ALPHA METHYLSEROTONIN; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; HISTAMINE; PROPRANOLOL; SALBUTAMOL; SEROTONIN 2 AGONIST;

AIRWAY; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GUINEA PIG; MALE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CAFFEINE; CALCIUM; GUINEA PIGS; KETANSERIN; MALE; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; PROPANOLAMINES; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TRACHEA;

EID: 33845997424     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2006.09.006     Document Type: Article

References (19)

1. Van Nueten J.M., Leysen J.E., Vanhoutte P.M., and Janssen P.A. Serotonergic responses in vascular and non-vascular tissues. Arch Int Pharmacodyn Ther 256 (1982) 331-334
2. 2 receptors in serotonin-induced contractions of nonvascular smooth muscle. J Pharmacol Exp Ther 232 (1985) 770-774
3. 2 receptors in tracheal smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 333 (1986) 91-97
4. Szarek J.L., Zhang J.Z., and Gruetter C.A. Mechanisms of 5-hydroxytryptamine-induced contraction of isolated rat intrapulmonary bronchi. Pulm Pharmacol 8 (1995) 273-281
5. Wilson H., Coffman W.J., and Cohen M.L. 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J Pharmacol Exp Ther 252 (1990) 683-688
6. Moffatt J.D., Cocks T.M., and Page C.P. Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea. Br J Pharmacol 141 (2004) 1159-1166
7. 2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin. J Med Chem 33 (1990) 755-758
8. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46 (1994) 157-203
9. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260 (1985) 3440-3450
10. Kajita J., and Yamaguchi H. Calcium mobilization by muscarinic cholinergic stimulation in bovine single airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 264 (1993) 496-503
11. 2+, caffeine and adenine nucleotides. Mol Pharmacol 31 (1987) 232-238
12. Ben-Harari R.R., Dalton B.A., and Garg U.C. Modulation of rate at which serotonin-induced contraction decays in guinea pig trachea. Am J Physiol Regul Integr Comp Physiol 266 (1994) 221-227
13. + channels of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 275 (1998) 448-459
14. Johnson M. The beta-adrenoceptor. Am J Respir Crit Care Med 158 (1998) S146-S153
15. 2-adrenoceptor-activated relaxation to isoprenaline through cAMP-dependent and -independent mechanisms in guinea-pig tracheal smooth muscle. J Smooth Muscle Res 39 (2003) 205-219
16. Hirota S., Helli P.B., Catalli A., Chew A., and Janssen L.J. Airway smooth muscle excitation-contraction coupling and airway hyperresponsiveness. Can J Physiol Pharmacol 83 (2005) 725-732
17. Yue C., Dodge K.L., Weber G., and Sanborn B.M. Phosphorylation of serine 1105 by protein kinase A inhibits phospholipase Cbeta3 stimulation by Galphaq. J Biol Chem 273 (1998) 18023-18027
18. Abdel-Latif A.A. Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle. Exp Biol Med 226 (2001) 153-163
19. 3 receptor. Respir Res 7 (2006) 34